ENSMUSG00000058444


Mus musculus

Features
Gene ID: ENSMUSG00000058444
  
Biological name :Map2k5
  
Synonyms : Dual specificity mitogen-activated protein kinase kinase 5 / Map2k5 / Q9WVS7
  
Possible biological names infered from orthology : mitogen-activated protein kinase kinase 5 / Q13163
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: C
Gene start: 63163768
Gene end: 63377902
  
Corresponding Affymetrix probe sets: 10594353 (MoGene1.0st)   1417854_at (Mouse Genome 430 2.0 Array)   1430180_at (Mouse Genome 430 2.0 Array)   1453712_a_at (Mouse Genome 430 2.0 Array)   1455941_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000034920
NCBI entrez gene - 23938     See in Manteia.
MGI - MGI:1346345
RefSeq - XM_011242741
RefSeq - NM_011840
RefSeq - XM_006511146
RefSeq - XM_011242740
RefSeq - XM_006511145
RefSeq Peptide - NP_035970
swissprot - Q9WVS7
Ensembl - ENSMUSG00000058444
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 map2k5ENSDARG00000011851Danio rerio
 MAP2K5ENSGALG00000007930Gallus gallus
 MAP2K5ENSG00000137764Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q63932 / Map2k2 / Mus musculus mitogen-activated protein kinase kinase 2 (Map2k2), transcript variant 2, mRNA. / P36507* / AC011005.1* / mitogen-activated protein kinase kinase 2*ENSMUSG0000003502734
Map2k1 / P31938 / Dual specificity mitogen-activated protein kinase kinase 1 / Q02750* / mitogen-activated protein kinase kinase 1*ENSMUSG0000000493632
Map2k3 / O09110 / mitogen-activated protein kinase kinase 3 / P46734*ENSMUSG0000001893229
Map2k6 / P70236 / mitogen-activated protein kinase kinase 6 / P52564*ENSMUSG0000002062329
Map2k4 / P47809 / Dual specificity mitogen-activated protein kinase kinase 4 / P45985* / mitogen-activated protein kinase kinase 4*ENSMUSG0000003335228
Map2k7 / Q8CE90 / Dual specificity mitogen-activated protein kinase kinase 7 / O14733* / mitogen-activated protein kinase kinase 7*ENSMUSG0000000294827
Map2k7 / Q8CE90 / Dual specificity mitogen-activated protein kinase kinase 7 / O14733* / mitogen-activated protein kinase kinase 7*ENSMUSG0000010906127


Protein motifs (from Interpro)
Interpro ID Name
 IPR000270  PB1 domain
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR034851  Dual specificity mitogen-activated protein kinase kinase 5, PB1 domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0000165 MAPK cascade IMP
 biological_processGO:0000187 activation of MAPK activity IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007346 regulation of mitotic cell cycle IBA
 biological_processGO:0007507 heart development IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0030307 positive regulation of cell growth IEA
 biological_processGO:0031098 stress-activated protein kinase signaling cascade IBA
 biological_processGO:0032088 negative regulation of NF-kappaB transcription factor activity IEA
 biological_processGO:0032147 activation of protein kinase activity IBA
 biological_processGO:0034115 negative regulation of heterotypic cell-cell adhesion IEA
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0045415 negative regulation of interleukin-8 biosynthetic process IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0050679 positive regulation of epithelial cell proliferation IEA
 biological_processGO:0051247 positive regulation of protein metabolic process IEA
 biological_processGO:0060761 negative regulation of response to cytokine stimulus IEA
 biological_processGO:0070375 ERK5 cascade IEA
 biological_processGO:0071363 cellular response to growth factor stimulus IEA
 biological_processGO:0090051 negative regulation of cell migration involved in sprouting angiogenesis IEA
 biological_processGO:2000342 negative regulation of chemokine (C-X-C motif) ligand 2 production IEA
 biological_processGO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005819 spindle IDA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IBA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
Show

Allelic Composition: Plaurtm1Mlg/Plaurtm1Mlg
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000292 distended pericardial sacs "stretched outer parietal layer of the pericardium" [J:25248]
Show

Allelic Composition: Plaurtm1Mlg/Plaurtm1Mlg
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000298 absent endocardial cushion "absence of the mounds of embryonic connective tissue that bulge into the embryonic atrioventricular canal" [MGI:CLS]
Show

Allelic Composition: Plaurtm1Mlg/Plaurtm1Mlg
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Plaurtm1Mlg/Plaurtm1Mlg
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Plaurtm1Mlg/Plaurtm1Mlg
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
Show

Allelic Composition: Plaurtm1Mlg/Plaurtm1Mlg
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Plaurtm1Mlg/Plaurtm1Mlg
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002189 abnormal myocardial trabeculae morphology "malformation of the supporting bundles of muscular fibers lining the walls of the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Plaurtm1Mlg/Plaurtm1Mlg
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Plaurtm1Mlg/Plaurtm1Mlg
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0010454 abnormal truncus arteriosis septation "anomaly in the process of dividing the common arterial trunk arising out of both heart ventricles to divide into the aorta and pulmonary artery during development" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Plaurtm1Mlg/Plaurtm1Mlg
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Plaurtm1Mlg/Plaurtm1Mlg
Genetic Background: involves: 129S2/SvPas * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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