MP:0000097 | short maxilla | "reduced length of the upper jaw bone" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:53370] |
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Allelic Composition: Map2k1tm1Chrn/Map2k1tm1Chrn,Map2k2tm1Chrn/Map2k2tm1Chrn,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J * SJL
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MP:0000260 | abnormal angiogenesis | "aberrant process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Lhx1tm2.1Bhr/Lhx1tm1Tmj,Tg(Rarb-cre)1Bhr/0 Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL
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MP:0000377 | abnormal hair follicle | "malformed invagination of the epidermis from which the hair shaft develops" [J:65031] |
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Allelic Composition: Map2k1Gt(ROSABetageo)J2Chrn/Map2k1Gt(ROSABetageo)J2Chrn Genetic Background: involves: 129/Sv * C57BL/6J * SJL
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MP:0000460 | mandible hypoplasia | "arrested growth or atrophy of the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator, J:54637] |
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Allelic Composition: Map2k1tm1Chrn/Map2k1tm1Chrn,Map2k2tm1Chrn/Map2k2tm1Chrn,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J * SJL
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MP:0000477 | abnormal intestine morphology | "malformation of the digestive tube passing from the stomach to the anus" [J:48968] |
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Allelic Composition: Map2k1tm1Chrn/Map2k1tm1Chrn,Map2k2tm1Chrn/Map2k2tm1Chrn,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd Genetic Background: involves: 129/Sv * C57BL/6J * SJL
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MP:0000490 | abnormal crypts of Lieberkuhn morphology | "malformation or defects in the tubular intestinal glands found in the mucosal membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Krastm1Bbd/Kras+,Map2k1tm1Chrn/Map2k1tm1Chrn,Map2k2tm1Chrn/Map2k2tm1Chrn Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL
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MP:0000764 | abnormal tongue epithelium morphology | "malformation of the epithelial layer of the tongue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc] |
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Allelic Composition: Map2k1Gt(ROSABetageo)J2Chrn/Map2k1Gt(ROSABetageo)J2Chrn Genetic Background: involves: 129/Sv * C57BL/6J * SJL
Allelic Composition: Map2k1tm1Chrn/Map2k1tm1Chrn,Map2k2tm1Chrn/Map2k2tm1Chrn,Tg(KRT14-cre/ERT2)1Ipc/? Genetic Background: involves: 129/Sv * C57BL/6J * SJL
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MP:0001196 | shiny skin | "skin with a glossy or glistening appearance" [J:56641] |
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Allelic Composition: Map2k1Gt(ROSABetageo)J2Chrn/Map2k1Gt(ROSABetageo)J2Chrn Genetic Background: involves: 129/Sv * C57BL/6J * SJL
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MP:0001201 | translucent skin | "skin that is more transparent to light than normal " [J:15108] |
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Allelic Composition: Map2k1Gt(ROSABetageo)J2Chrn/Map2k1Gt(ROSABetageo)J2Chrn Genetic Background: involves: 129/Sv * C57BL/6J * SJL
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MP:0001215 | skin hypoplasia | "underdevelopment of the cutis, usually due to a deficiency in the number of cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Map2k1Gt(ROSABetageo)J2Chrn/Map2k1Gt(ROSABetageo)J2Chrn Genetic Background: involves: 129/Sv * C57BL/6J * SJL
Allelic Composition: Map2k1tm1Chrn/Map2k1tm1Chrn,Map2k2tm1Chrn/Map2k2tm1Chrn,Tg(KRT14-cre/ERT2)1Ipc/? Genetic Background: involves: 129/Sv * C57BL/6J * SJL
Allelic Composition: Map2k1tm1Chrn/Map2k1tm1Chrn,Map2k2tm1Chrn/Map2k2tm1Chrn,Tg(KRT14-RAF1/ESR1)1Pkha/? Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6J * SJL
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MP:0001262 | decreased body weight | "lower than normal average weight " [J:61295] |
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Allelic Composition: Map2k1Gt(ROSABetageo)J2Chrn/Map2k1Gt(ROSABetageo)J2Chrn Genetic Background: involves: 129/Sv * C57BL/6J * SJL
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MP:0001265 | reduced body size | "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170] |
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Allelic Composition: Map2k1Gt(ROSABetageo)J2Chrn/Map2k1Gt(ROSABetageo)J2Chrn Genetic Background: involves: 129/Sv * C57BL/6J * SJL
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MP:0001299 | abnormal eye distance/ position | "abnormal placement of the eyes in relation to each other or in relation to other craniofacial structures" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Map2k1tm1Chrn/Map2k1tm1Chrn,Map2k2tm1Chrn/Map2k2tm1Chrn,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J * SJL
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MP:0001302 | eyelids open at birth | "widely open eyes instead of closed at perinatal stage" [J:51966] |
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Allelic Composition: Map2k1Gt(ROSABetageo)J2Chrn/Map2k1Gt(ROSABetageo)J2Chrn Genetic Background: involves: 129/Sv * C57BL/6J * SJL
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MP:0001698 | reduced embryo size | "smaller proportions of embryo compared to littermates" [J:61790] |
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Allelic Composition: Lhx1tm2.1Bhr/Lhx1tm1Tmj,Tg(Rarb-cre)1Bhr/0 Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL
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MP:0001711 | abnormal placenta | |
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Allelic Composition: Cdh23v-6J/Cdh23v-6J Genetic Background: B10.A-H2h4/(4R)SgDvEgJ-Cdh23v-6J/J
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MP:0001716 | abnormal placental labyrinth | "malformed structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [J:23171] |
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Allelic Composition: Lhx1tm2.1Bhr/Lhx1tm1Tmj,Tg(Rarb-cre)1Bhr/0 Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL
Allelic Composition: Map2k1Gt(ROSABetageo)J2Chrn/Map2k1Gt(ROSABetageo)J2Chrn Genetic Background: involves: 129/Sv * C57BL/6J * SJL
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MP:0001717 | absent ectoplacental cone | |
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Allelic Composition: Map2k1tm1.1Bacc/Map2k1tm1.1Bacc Genetic Background: 129-Map2k1tm1.1Bacc
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MP:0001722 | pale yolk sac | "bloodless yolk sac" [J:62571] |
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Allelic Composition: Lhx1tm2.1Bhr/Lhx1tm1Tmj,Tg(Rarb-cre)1Bhr/0 Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL
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MP:0001732 | postnatal growth retardation | "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Map2k1tm1.1Bacc/Map2k1tm1.1Bacc Genetic Background: 129-Map2k1tm1.1Bacc
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MP:0002083 | premature death | "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Mapk1tm1.1Hed/Mapk1tm1.1Hed,Mapk3tm1Gpg/Mapk3tm1Gpg,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd Genetic Background: involves: 129/Sv
Allelic Composition: Krastm1Bbd/Kras+,Map2k1tm1Chrn/Map2k1tm1Chrn,Map2k2tm1Chrn/Map2k2tm1Chrn Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL
Allelic Composition: Map2k1tm1Chrn/Map2k1tm1Chrn,Map2k2tm1Chrn/Map2k2tm1Chrn,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd Genetic Background: involves: 129/Sv * C57BL/6J * SJL
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MP:0002169 | no phenotype detected | "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Map2k1tm1Bacc/Map2k1tm1.1Bacc,Edil3Tg(Sox2-cre)1Amc/Edil3+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
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MP:0002177 | abnormal outer ear morphology | "malformation or malfunction of any components of the auricles or external acoustic meatus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Map2k1Gt(ROSABetageo)J2Chrn/Map2k1Gt(ROSABetageo)J2Chrn Genetic Background: involves: 129/Sv * C57BL/6J * SJL
Allelic Composition: Map2k1tm1Chrn/Map2k1tm1Chrn,Map2k2tm1Chrn/Map2k2tm1Chrn,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J * SJL
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MP:0002633 | persistent truncus arteriosis | "complete failure of the common arterial trunk opening out of both ventricles to divide into the aorta and pulmonary artery during development" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Map2k1tm1Chrn/Map2k1tm1Chrn,Map2k2tm1Chrn/Map2k2tm1Chrn,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J * SJL
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MP:0002796 | impaired skin barrier function | "impaired ability of the skin to regulate water loss; frequently leads to dehydration" [J:56641] |
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Allelic Composition: Map2k1Gt(ROSABetageo)J2Chrn/Map2k1Gt(ROSABetageo)J2Chrn Genetic Background: involves: 129/Sv * C57BL/6J * SJL
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MP:0003091 | abnormal cell migration | "defect in the movement of cells during developmental processes" [smb:Susan M. Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Lhx1tm2.1Bhr/Lhx1tm1Tmj,Tg(Rarb-cre)1Bhr/0 Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL
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MP:0003544 | abnormal vascular endothelial cell migration | "anomaly in the movement of endothelial cell or their precursors to the appropriate location in the body" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95387] |
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Allelic Composition: Lhx1tm2.1Bhr/Lhx1tm1Tmj,Tg(Rarb-cre)1Bhr/0 Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL
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MP:0004255 | abnormal spongiotrophoblast layer morphology | "anomaly in the structure of the outer structural layer of the rodent placenta" [PMID:11433360] |
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Allelic Composition: Lhx1tm2.1Bhr/Lhx1tm1Tmj,Tg(Rarb-cre)1Bhr/0 Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL
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MP:0004259 | small placenta | "reduced size of the size or shape of the organ of metabolic interchange between fetus and mother" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Map2k1Gt(ROSABetageo)J2Chrn/Map2k1Gt(ROSABetageo)J2Chrn Genetic Background: involves: 129/Sv * C57BL/6J * SJL
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MP:0005031 | abnormal trophoblast | "malformation of the mesectodermal cell layer covering the blastocyst that erodes the uterine mucosa and contributes to the formation of the placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Map2k1tm1.1Bacc/Map2k1tm1.1Bacc Genetic Background: 129-Map2k1tm1.1Bacc
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MP:0005605 | increased bone mass | "an increase in the total amount of bone tissue contained in the skeleton" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Hivep3tm3Glm/Hivep3+,Map2k1tm1Chrn/Map2k1tm1Chrn,Map2k2tm1Chrn/Map2k2tm1Chrn,Tg(Prrx1-cre)1Cjt/0 Genetic Background: involves: 129 * C57BL/6J * SJL * SJL/J
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MP:0008716 | lung non-small cell carcinoma | "a heterogeneous aggregate of at least three distinct histological types of lung cancer" [MESH:C04.557.470.200.300] |
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Allelic Composition: Krastm1Bbd/Kras+,Map2k1tm1Chrn/Map2k1tm1Chrn Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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MP:0008803 | abnormal placental labyrinth vasculature morphology | "any structural anomaly in blood vessels of the layer of the placenta where embryonic and maternal blood vessels interdigitate" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Lhx1tm2.1Bhr/Lhx1tm1Tmj,Tg(Rarb-cre)1Bhr/0 Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL
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MP:0009580 | increased keratinocyte apoptosis | "increase in the number of keratinocytes undergoing programmed cell death" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Map2k1Gt(ROSABetageo)J2Chrn/Map2k1Gt(ROSABetageo)J2Chrn Genetic Background: involves: 129/Sv * C57BL/6J * SJL
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MP:0009905 | absent tongue | "absence of the mobile mass of muscular tissue and surrounding epithelial tissue occupying the cavity of the mouth and forming part of the floor" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Map2k1tm1Chrn/Map2k1tm1Chrn,Map2k2tm1Chrn/Map2k2tm1Chrn,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J * SJL
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MP:0010234 | abnormal vibrissa follicle morphology | "any structural anomaly of one of the tubular invaginations of the epidermis enclosing the hair roots and from which grow the vibrissae located on the muzzle and face of many species" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Map2k1Gt(ROSABetageo)J2Chrn/Map2k1Gt(ROSABetageo)J2Chrn Genetic Background: involves: 129/Sv * C57BL/6J * SJL
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MP:0010283 | decreased classified tumor incidence | "less than the expected number of tumors with a specific classification type in a given population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Krastm1Bbd/Kras+,Map2k1tm1Chrn/Map2k1tm1Chrn,Map2k2tm1Chrn/Map2k2tm1Chrn Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL
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MP:0011088 | partial neonatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith] |
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Allelic Composition: Map2k1Gt(ROSABetageo)J2Chrn/Map2k1Gt(ROSABetageo)J2Chrn Genetic Background: involves: 129/Sv * C57BL/6J * SJL
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MP:0011098 | complete embryonic lethality during organogenesis | "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith] |
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Allelic Composition: Cdh23v-6J/Cdh23v-6J Genetic Background: B10.A-H2h4/(4R)SgDvEgJ-Cdh23v-6J/J
Allelic Composition: Map2k1Gt(ROSABetageo)J2Chrn/Map2k1Gt(ROSABetageo)J2Chrn Genetic Background: involves: 129/Sv * C57BL/6J * SJL
Allelic Composition: Map2k1tm1.1Bacc/Map2k1tm1.1Bacc Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Map2k1tm1.1Bacc/Map2k1tm1.1Bacc Genetic Background: 129-Map2k1tm1.1Bacc
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MP:0011108 | partial embryonic lethality during organogenesis | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith] |
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Allelic Composition: Lhx1tm2.1Bhr/Lhx1tm1Tmj,Tg(Rarb-cre)1Bhr/0 Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL
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MP:0013241 | embryo tissue necrosis | "morphological changes resulting from pathological death of some or all embryo tissue; usually due to irreversible damage" [MGI:csmith] |
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Allelic Composition: Lhx1tm2.1Bhr/Lhx1tm1Tmj,Tg(Rarb-cre)1Bhr/0 Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL
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