ENSDARG00000007825


Danio rerio

Features
Gene ID: ENSDARG00000007825
  
Biological name :map2k1
  
Synonyms : map2k1 / mitogen-activated protein kinase kinase 1
  
Possible biological names infered from orthology : Dual specificity mitogen-activated protein kinase kinase 1 / P31938 / Q02750
  
Species: Danio rerio
  
Chr. number: 18
Strand: 1
Band:
Gene start: 19419120
Gene end: 19451165
  
Corresponding Affymetrix probe sets: Dr.25154.1.S1_at (Zebrafish Array)   NM_213419_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000008018
NCBI entrez gene - 406728     See in Manteia.
RefSeq - NM_213419
RefSeq Peptide - NP_998584
swissprot - A5WWB4
ZFIN ID - ZDB-GENE-040426-2759
Ensembl - ENSDARG00000007825
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MAP2K1ENSGALG00000007687Gallus gallus
 MAP2K1ENSG00000169032Homo sapiens
 Map2k1ENSMUSG00000004936Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
map2k2a / mitogen-activated protein kinase kinase 2a / P36507* / MAP2K2* / Q63932* / AC011005.1* / mitogen-activated protein kinase kinase 2* / Mus musculus mitogen-activated protein kinase...ENSDARG0000000660977
map2k2b / mitogen-activated protein kinase kinase 2b / P36507* / MAP2K2* / Q63932* / AC011005.1* / mitogen-activated protein kinase kinase 2* / Mus musculus mitogen-activated protein kinase...ENSDARG0000006891876
map2k5 / mitogen-activated protein kinase kinase 5 / Q13163* / Q9WVS7* / Dual specificity mitogen-activated protein kinase kinase 5 *ENSDARG0000001185136
map2k4a / mitogen-activated protein kinase kinase 4a / P45985* / MAP2K4* / P47809* / mitogen-activated protein kinase kinase 4* / Dual specificity mitogen-activated protein kinase kinase 4 *ENSDARG0000006358333
map2k4b / mitogen-activated protein kinase kinase 4b / P45985* / MAP2K4* / P47809* / mitogen-activated protein kinase kinase 4* / Dual specificity mitogen-activated protein kinase kinase 4 *ENSDARG0000007717733
map2k6 / Q9DGE0 / mitogen-activated protein kinase kinase 6 / P52564*ENSDARG0000009918432
map2k7 / mitogen-activated protein kinase kinase 7 / O14733* / Q8CE90* / Dual specificity mitogen-activated protein kinase kinase 7 *ENSDARG0000000827932


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007346 regulation of mitotic cell cycle IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0023014 signal transduction by protein phosphorylation IBA
 biological_processGO:0031098 stress-activated protein kinase signaling cascade IBA
 biological_processGO:0032147 activation of protein kinase activity IBA
 biological_processGO:0042981 regulation of apoptotic process IBA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA


Pathways (from Reactome)
Pathway description
MAPK3 (ERK1) activation
Signal transduction by L1
RAF activation
MAP2K and MAPK activation
Negative feedback regulation of MAPK pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr