ENSDARG00000068918


Danio rerio

Features
Gene ID: ENSDARG00000068918
  
Biological name :map2k2b
  
Synonyms : map2k2b / mitogen-activated protein kinase kinase 2b
  
Possible biological names infered from orthology : AC011005.1 / MAP2K2 / mitogen-activated protein kinase kinase 2 / Mus musculus mitogen-activated protein kinase kinase 2 (Map2k2), transcript variant 2, mRNA. / P36507 / Q63932
  
Species: Danio rerio
  
Chr. number: 2
Strand: -1
Band:
Gene start: 57416844
Gene end: 57443210
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000090612
Ensembl peptide - ENSDARP00000124788
NCBI entrez gene - 100002225     See in Manteia.
RefSeq - NM_001128281
RefSeq Peptide - NP_001121753
swissprot - F1QWJ5
ZFIN ID - ZDB-GENE-080219-34
Ensembl - ENSDARG00000068918
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MAP2K2ENSGALG00000001267Gallus gallus
 AC011005.1ENSG00000230626Homo sapiens
 MAP2K2ENSG00000126934Homo sapiens
 Map2k2ENSMUSG00000035027Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
map2k2a / mitogen-activated protein kinase kinase 2a / P36507* / MAP2K2* / Q63932* / AC011005.1* / mitogen-activated protein kinase kinase 2* / Mus musculus mitogen-activated protein kinase...ENSDARG0000000660988
map2k1 / mitogen-activated protein kinase kinase 1 / P31938* / Q02750* / Dual specificity mitogen-activated protein kinase kinase 1 *ENSDARG0000000782576
map2k5 / mitogen-activated protein kinase kinase 5 / Q13163* / Q9WVS7* / Dual specificity mitogen-activated protein kinase kinase 5 *ENSDARG0000001185136
map2k4a / mitogen-activated protein kinase kinase 4a / P45985* / MAP2K4* / P47809* / mitogen-activated protein kinase kinase 4* / Dual specificity mitogen-activated protein kinase kinase 4 *ENSDARG0000006358333
map2k4b / mitogen-activated protein kinase kinase 4b / P45985* / MAP2K4* / P47809* / mitogen-activated protein kinase kinase 4* / Dual specificity mitogen-activated protein kinase kinase 4 *ENSDARG0000007717732
map2k7 / mitogen-activated protein kinase kinase 7 / O14733* / Q8CE90* / Dual specificity mitogen-activated protein kinase kinase 7 *ENSDARG0000000827932
map2k6 / Q9DGE0 / mitogen-activated protein kinase kinase 6 / P52564*ENSDARG0000009918430


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007346 regulation of mitotic cell cycle IBA
 biological_processGO:0023014 signal transduction by protein phosphorylation IBA
 biological_processGO:0031098 stress-activated protein kinase signaling cascade IBA
 biological_processGO:0032147 activation of protein kinase activity IBA
 biological_processGO:0042981 regulation of apoptotic process IBA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA


Pathways (from Reactome)
Pathway description
MAPK1 (ERK2) activation
Signal transduction by L1
RAF activation
MAP2K and MAPK activation
Negative feedback regulation of MAPK pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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