ENSDARG00000006609


Danio rerio

Features
Gene ID: ENSDARG00000006609
  
Biological name :map2k2a
  
Synonyms : map2k2a / mitogen-activated protein kinase kinase 2a
  
Possible biological names infered from orthology : AC011005.1 / MAP2K2 / mitogen-activated protein kinase kinase 2 / Mus musculus mitogen-activated protein kinase kinase 2 (Map2k2), transcript variant 2, mRNA. / P36507 / Q63932
  
Species: Danio rerio
  
Chr. number: 22
Strand: -1
Band:
Gene start: 20388621
Gene end: 20403194
  
Corresponding Affymetrix probe sets: Dr.8.3.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000014914
NCBI entrez gene - 563181     See in Manteia.
swissprot - Q1LY62
ZFIN ID - ZDB-GENE-041027-1
Ensembl - ENSDARG00000006609
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MAP2K2ENSGALG00000001267Gallus gallus
 AC011005.1ENSG00000230626Homo sapiens
 MAP2K2ENSG00000126934Homo sapiens
 Map2k2ENSMUSG00000035027Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
map2k2b / mitogen-activated protein kinase kinase 2b / P36507* / MAP2K2* / Q63932* / AC011005.1* / mitogen-activated protein kinase kinase 2* / Mus musculus mitogen-activated protein kinase...ENSDARG0000006891887
map2k1 / mitogen-activated protein kinase kinase 1 / P31938* / Q02750* / Dual specificity mitogen-activated protein kinase kinase 1 *ENSDARG0000000782577
map2k5 / mitogen-activated protein kinase kinase 5 / Q13163* / Q9WVS7* / Dual specificity mitogen-activated protein kinase kinase 5 *ENSDARG0000001185136
map2k4b / mitogen-activated protein kinase kinase 4b / P45985* / MAP2K4* / P47809* / mitogen-activated protein kinase kinase 4* / Dual specificity mitogen-activated protein kinase kinase 4 *ENSDARG0000007717732
map2k4a / mitogen-activated protein kinase kinase 4a / P45985* / MAP2K4* / P47809* / mitogen-activated protein kinase kinase 4* / Dual specificity mitogen-activated protein kinase kinase 4 *ENSDARG0000006358332
map2k7 / mitogen-activated protein kinase kinase 7 / O14733* / Q8CE90* / Dual specificity mitogen-activated protein kinase kinase 7 *ENSDARG0000000827932
map2k6 / Q9DGE0 / mitogen-activated protein kinase kinase 6 / P52564*ENSDARG0000009918430


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007346 regulation of mitotic cell cycle IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0023014 signal transduction by protein phosphorylation IBA
 biological_processGO:0031098 stress-activated protein kinase signaling cascade IBA
 biological_processGO:0032147 activation of protein kinase activity IBA
 biological_processGO:0042981 regulation of apoptotic process IBA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA


Pathways (from Reactome)
Pathway description
MAPK1 (ERK2) activation
Signal transduction by L1
RAF activation
MAP2K and MAPK activation
Negative feedback regulation of MAPK pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000017661 braf / B-Raf proto-oncogene, serine/threonine kinase / P15056* / P28028* / Serine/threonine-protein kinase B-raf *  / complex / reaction
 ENSDARG00000026630 mark3b / MAP/microtubule affinity-regulating kinase 3b / MARK1* / MARK3* / P27448* / Q9P0L2* / Q8VHJ5* / Q03141* / Serine/threonine-protein kinase MARK1 * / microtubule affinity regulating ...  / complex / reaction
 ENSDARG00000039872 lamtor2 / late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 / Q9JHS3* / Q9Y2Q5* / Ragulator complex protein LAMTOR2 *  / reaction / complex
 ENSDARG00000098359 il17rd / interleukin 17 receptor D / Q8NFM7*  / complex / reaction
 ENSDARG00000027552 mapk1 / mitogen-activated protein kinase 1 / P28482* / P63085* / Mus musculus mitogen-activated protein kinase 1 (Mapk1), transcript variant 3, mRNA.*  / complex / reaction
 ENSDARG00000057075 lamtor3 / late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 / O88653* / Q9UHA4*  / complex / reaction
 ENSDARG00000070573 mapk3 / mitogen-activated protein kinase 3 / P27361* / Q63844*  / reaction / complex
 ENSDARG00000006609 map2k2a / mitogen-activated protein kinase kinase 2a / P36507* / MAP2K2* / Q63932* / AC011005.1* / mitogen-activated protein kinase kinase 2* / Mus musculus mitogen-activated protein kinase...  / complex
 ENSDARG00000005651 hrasb / -Ha-ras Harvey rat sarcoma viral oncogene homolog b / HRAS* / P01112* / Q61411* / HRas proto-oncogene, GTPase* / GTPase HRas GTPase HRas, N-terminally processed*  / complex / reaction
 ENSDARG00000013078 ywhaba / Q5PRD0 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide a / YWHAB* / P31946* / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activat...  / reaction / complex
 ENSDARG00000038225 nras / NRAS proto-oncogene, GTPase / P01111* / neuroblastoma ras oncogene*  / complex / reaction






 

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