ENSGALG00000001267


Gallus gallus

Features
Gene ID: ENSGALG00000001267
  
Biological name :MAP2K2
  
Synonyms : dual specificity mitogen-activated protein kinase kinase 2 / MAP2K2
  
Possible biological names infered from orthology : AC011005.1 / mitogen-activated protein kinase kinase 2 / Mus musculus mitogen-activated protein kinase kinase 2 (Map2k2), transcript variant 2, mRNA. / P36507 / Q63932
  
Species: Gallus gallus
  
Chr. number: 28
Strand: 1
Band:
Gene start: 2637819
Gene end: 2646108
  
Corresponding Affymetrix probe sets: Gga.2391.1.S1_at (Chicken Array)   GgaAffx.845.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000050311
Ensembl peptide - ENSGALP00000001932
NCBI entrez gene - 396349     See in Manteia.
RefSeq - XM_015299918
RefSeq - NM_205388
RefSeq Peptide - NP_990719
swissprot - A0A1D5PC26
swissprot - F1NYZ2
Ensembl - ENSGALG00000001267
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 map2k2aENSDARG00000006609Danio rerio
 map2k2bENSDARG00000068918Danio rerio
 AC011005.1ENSG00000230626Homo sapiens
 MAP2K2ENSG00000126934Homo sapiens
 Map2k2ENSMUSG00000035027Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MAP2K1 / mitogen-activated protein kinase kinase 1 / P31938* / Q02750* / Dual specificity mitogen-activated protein kinase kinase 1 *ENSGALG0000000768783
MAP2K5 / dual specificity mitogen-activated protein kinase kinase 5 / Q13163* / Q9WVS7* / mitogen-activated protein kinase kinase 5*ENSGALG0000000793036
MAP2K4 / mitogen-activated protein kinase kinase 4 / P45985* / P47809* / Dual specificity mitogen-activated protein kinase kinase 4 *ENSGALG0000003217833
MAP2K6 / mitogen-activated protein kinase kinase 6 / P52564* / P70236*ENSGALG0000000437031
MAP2K3 / mitogen-activated protein kinase kinase 3 / O09110* / P46734*ENSGALG0000004128531


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001932 regulation of protein phosphorylation IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007507 heart development IEA
 biological_processGO:0030878 thyroid gland development IEA
 biological_processGO:0048538 thymus development IEA
 biological_processGO:0048679 regulation of axon regeneration IEA
 biological_processGO:0050772 positive regulation of axonogenesis IEA
 biological_processGO:0060324 face development IEA
 biological_processGO:0060425 lung morphogenesis IEA
 biological_processGO:0060440 trachea formation IEA
 biological_processGO:0060502 epithelial cell proliferation involved in lung morphogenesis IEA
 biological_processGO:0070371 ERK1 and ERK2 cascade IEA
 biological_processGO:2000147 positive regulation of cell motility IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0032947 protein-containing complex scaffold activity IEA


Pathways (from Reactome)
Pathway description
MAPK1 (ERK2) activation
Signal transduction by L1
MAP2K and MAPK activation
Negative feedback regulation of MAPK pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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