ENSMUSG00000040717


Mus musculus

Features
Gene ID: ENSMUSG00000040717
  
Biological name :Il17rd
  
Synonyms : Il17rd / Interleukin-17 receptor D / Q8JZL1
  
Possible biological names infered from orthology : Q8NFM7
  
Species: Mus musculus
  
Chr. number: 14
Strand: 1
Band: A3
Gene start: 27038941
Gene end: 27107286
  
Corresponding Affymetrix probe sets: 10413398 (MoGene1.0st)   10413416 (MoGene1.0st)   1429893_at (Mouse Genome 430 2.0 Array)   1452471_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000153543
Ensembl peptide - ENSMUSP00000036076
Ensembl peptide - ENSMUSP00000153108
Ensembl peptide - ENSMUSP00000153140
NCBI entrez gene - 171463     See in Manteia.
MGI - MGI:2159727
RefSeq - XM_006518667
RefSeq - XM_006518668
RefSeq - NM_134437
RefSeq Peptide - NP_602319
swissprot - Q3V0D5
swissprot - A0A286YCS2
swissprot - Q8JZL1
Ensembl - ENSMUSG00000040717
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 il17rdENSDARG00000098359Danio rerio
 IL17RDENSGALG00000005499Gallus gallus
 IL17RDENSG00000144730Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Il17ra / Q60943 / Interleukin-17 receptor A / Q96F46*ENSMUSG0000000289718
Il17rb / Q9JIP3 / Interleukin-17 receptor B / Q9NRM6*ENSMUSG0000001596610


Protein motifs (from Interpro)
Interpro ID Name
 IPR013087  Zinc finger C2H2-type
 IPR013568  SEFIR domain
 IPR013783  Immunoglobulin-like fold
 IPR031951  Interleukin 17 receptor D, N-terminal
 IPR035897  Toll/interleukin-1 receptor homology (TIR) domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0019221 cytokine-mediated signaling pathway IEA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005794 Golgi apparatus ISO
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0030368 interleukin-17 receptor activity IBA


Pathways (from Reactome)
Pathway description
MAP2K and MAPK activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000849 abnormal cerebellum morphology "any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Hey2tm1Eno/Hey2tm2Eno,Tg(Tagln-cre)1Her/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Il17rdGt(KST223)Byg/Il17rd+
Genetic Background: B6.129P2-Il17rdGt(KST223)Byg

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Birc6tm1Nai/Birc6tm1Nai
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0002834 decreased heart weight "less than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Ift88tm1.1(KOMP)Vlcg/Ift88+
Genetic Background: C57BL/6N-Ift88tm1.1(KOMP)Vlcg/J

 MP:0004953 decreased spleen weight "reduction in the average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ift88tm1.1(KOMP)Vlcg/Ift88+
Genetic Background: C57BL/6N-Ift88tm1.1(KOMP)Vlcg/J

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
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Allelic Composition: Hey2tm1Eno/Hey2tm2Eno,Tg(Tagln-cre)1Her/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0012490 abnormal cochlear VIII nucleus morphology "any structural anomaly of two paired brainstem nuclei, the dorsal cochlear nucleus and the ventral cochlear nucleus, that lie dorsal and ventral, respectively, to the inferior cerebellar peduncle at the rostral pole of the medulla; the cochlear nuclei receive input from the cochlear nerve and send projections to the inferior colliculus, the medial geniculate, and other forebrain structures" [MGI:csmith]
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Allelic Composition: Hey2tm1Eno/Hey2tm2Eno,Tg(Tagln-cre)1Her/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Il17rdGt(KST223)Byg/Il17rd+
Genetic Background: B6.129P2-Il17rdGt(KST223)Byg

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000004936 Map2k1 / P31938 / Dual specificity mitogen-activated protein kinase kinase 1 / Q02750* / mitogen-activated protein kinase kinase 1*  / complex / reaction
 ENSMUSG00000063065 Mapk3 / Q63844 / Mitogen-activated protein kinase 3 / P27361*  / complex / reaction
 ENSMUSG00000035027 Q63932 / Map2k2 / Mus musculus mitogen-activated protein kinase kinase 2 (Map2k2), transcript variant 2, mRNA. / P36507* / AC011005.1* / mitogen-activated protein kinase kinase 2*  / complex / reaction
 ENSMUSG00000063358 Mapk1 / P63085 / Mus musculus mitogen-activated protein kinase 1 (Mapk1), transcript variant 3, mRNA. / P28482* / mitogen-activated protein kinase 1*  / complex / reaction






 

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