ENSMUSG00000015966


Mus musculus

Features
Gene ID: ENSMUSG00000015966
  
Biological name :Il17rb
  
Synonyms : Il17rb / Interleukin-17 receptor B / Q9JIP3
  
Possible biological names infered from orthology : Q9NRM6
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: B
Gene start: 29996135
Gene end: 30008896
  
Corresponding Affymetrix probe sets: 10418341 (MoGene1.0st)   1420678_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000016110
Ensembl peptide - ENSMUSP00000121407
Ensembl peptide - ENSMUSP00000117802
Ensembl peptide - ENSMUSP00000113686
NCBI entrez gene - 50905     See in Manteia.
MGI - MGI:1355292
RefSeq - NM_019583
RefSeq Peptide - NP_062529
swissprot - Q543U7
swissprot - D6REG3
swissprot - Q9JIP3
swissprot - D6RCY5
swissprot - D3Z4T0
Ensembl - ENSMUSG00000015966
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 IL17RBENSG00000056736Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Il17ra / Q60943 / Interleukin-17 receptor A / Q96F46*ENSMUSG0000000289723
Il17rd / Q8JZL1 / Interleukin-17 receptor D / Q8NFM7*ENSMUSG0000004071715


Protein motifs (from Interpro)
Interpro ID Name
 IPR013568  SEFIR domain
 IPR032356  Interleukin-17 receptor, fibronectin-III-like domain 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0019221 cytokine-mediated signaling pathway IEA
 biological_processGO:0050729 positive regulation of inflammatory response IMP
 biological_processGO:2000664 positive regulation of interleukin-5 secretion IMP
 biological_processGO:2000667 positive regulation of interleukin-13 secretion IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004896 cytokine receptor activity ISS
 molecular_functionGO:0030368 interleukin-17 receptor activity IBA


Pathways (from Reactome)
Pathway description
Interleukin-17 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001876 decreased inflammatory response "less than expected response to injury, infection, or insult" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Chn1Gt714Lex/Chn1+,Epha4tm1Pch/Epha4+
Genetic Background: involves: 129S2/SvPas * 129S5/SvEvBrd

 MP:0002335 decreased airway responsiveness "less easily provoked into bronchoconstriction during bronchial provocation testing" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il17rbtm1Hwata/Il17rbtm1Hwata
Genetic Background: B6.Cg-Il17rbtm1Hwata

 MP:0002492 decreased IgE "less than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lmnatm6Lgf/Lmna+,Zmpste24tm1Sgy/Zmpste24tm1Sgy
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Il17rbtm1Anjm/Il17rbtm1Anjm,Il1rl1tm1Anjm/Il1rl1tm1Anjm
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0005012 decreased eosinophil count "fewer than normal eosinophil numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lmnatm6Lgf/Lmna+,Zmpste24tm1Sgy/Zmpste24tm1Sgy
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Il17rbtm1Anjm/Il17rbtm1Anjm,Il1rl1tm1Anjm/Il1rl1tm1Anjm
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Il13tm3.1Anjm/Il13+,Il17rbtm1Anjm/Il17rbtm1Anjm
Genetic Background: involves: BALB/c * C57BL/6

Allelic Composition: Il13tm3.1Anjm/Il13+,Il17rbtm1Anjm/Il17rbtm1Anjm,Il1rl1tm1Anjm/Il1rl1tm1Anjm
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0005027 increased susceptibility to parasitic infection "greater likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lmnatm6Lgf/Lmna+,Zmpste24tm1Sgy/Zmpste24tm1Sgy
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Il17rbtm1Anjm/Il17rbtm1Anjm,Il1rl1tm1Anjm/Il1rl1tm1Anjm
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0008040 decreased NK T cell number "reduced number of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865]
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Allelic Composition: Lrp2tm3Tew/Lrp2tm3Tew
Genetic Background: Not Specified

 MP:0008396 abnormal osteoclast differentiation "atypical production of or inability to produce bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Taglntm1Liw/Taglntm1Liw
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008539 decreased susceptibility to induced colitis "decreased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il25tm1Cdon/Il25tm1Cdon,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6N * SJL

Allelic Composition: Il17rbtm1Hwata/Il17rb+
Genetic Background: Not Specified

 MP:0008568 abnormal interleukin secretion "anomaly in the production or cellular release of soluble factors which stimulate growth-related activities of leukocytes and other cell types, that can act to enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]
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Allelic Composition: Lrp2tm3Tew/Lrp2tm3Tew
Genetic Background: Not Specified

Allelic Composition: Il17rbtm1Hwata/Il17rbtm1Hwata
Genetic Background: C.Cg-Il17rbtm1Hwata

 MP:0008661 decreased interleukin-10 secretion "reduction in the production or release of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
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Allelic Composition: Lrp2tm3Tew/Lrp2tm3Tew
Genetic Background: Not Specified

Allelic Composition: Il17rbtm1Hwata/Il17rbtm1Hwata
Genetic Background: C.Cg-Il17rbtm1Hwata

 MP:0008673 decreased interleukin-13 secretion "reduction in the production or release of a cytokine synthesized by T-cells that produces proliferation, immunoglobulin isotype switching, and immunoglobulin production by immature B-cells, and appears to play a role in regulating inflammatory and immune responses" [MESH:D12.644.276.374.465.513]
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Allelic Composition: Chn1Gt714Lex/Chn1+,Epha4tm1Pch/Epha4+
Genetic Background: involves: 129S2/SvPas * 129S5/SvEvBrd

Allelic Composition: Il17rbtm1Hwata/Il17rbtm1Hwata
Genetic Background: B6.Cg-Il17rbtm1Hwata

Allelic Composition: Il17rbtm1Hwata/Il17rbtm1Hwata
Genetic Background: C.Cg-Il17rbtm1Hwata

 MP:0008682 decreased interleukin-17 secretion "reduction in the production or release of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517]
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Allelic Composition: Il17rbtm1Hwata/Il17rbtm1Hwata
Genetic Background: B6.Cg-Il17rbtm1Hwata

Allelic Composition: Il17rbtm1Hwata/Il17rbtm1Hwata
Genetic Background: C.Cg-Il17rbtm1Hwata

 MP:0008703 decreased interleukin-5 secretion "reduction in the production or release of a cytokine that promotes differentiation and activation of eosinophils; it also triggers activated B-cells to differentiate into immunoglobulin-secreting cells" [MESH:D12.644.276.374.465.505]
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Allelic Composition: Chn1Gt714Lex/Chn1+,Epha4tm1Pch/Epha4+
Genetic Background: involves: 129S2/SvPas * 129S5/SvEvBrd

Allelic Composition: Il17rbtm1Lex/Il17rbtm1Lex
Genetic Background: C.129-Il17rbtm1Lex

Allelic Composition: Il17rbtm1Hwata/Il17rbtm1Hwata
Genetic Background: C.Cg-Il17rbtm1Hwata

 MP:0008706 decreased interleukin-6 secretion "reduction in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Il17rbtm1Lex/Il17rbtm1Lex
Genetic Background: C.129-Il17rbtm1Lex

 MP:0008712 decreased interleukin-9 secretion "reduction in the production or release of a multifunctional cytokine secreted by primarily by activated TH2 cells that may play a role as a regulator of allergic inflammation, and has been shown to enhance the growth and differentiation of mast cells, and can act on a variety of other immune cells" [MESH:D12.644.276.374.465.509]
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Allelic Composition: Il17rbtm1Hwata/Il17rbtm1Hwata
Genetic Background: B6.Cg-Il17rbtm1Hwata

Allelic Composition: Il17rbtm1Hwata/Il17rbtm1Hwata
Genetic Background: C.Cg-Il17rbtm1Hwata

 MP:0008722 abnormal chemokine secretion "anomaly in the production or cellular release of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200]
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Allelic Composition: Il17rbtm1Lex/Il17rbtm1Lex
Genetic Background: C.129-Il17rbtm1Lex

 MP:0010181 decreased susceptibility to weight loss "smaller decrease in body weight over time when compared to the average decrease in weight in response to dietary modification, fasting or caloric restriction" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il25tm1Cdon/Il25tm1Cdon,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6N * SJL

Allelic Composition: Il17rbtm1Hwata/Il17rb+
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000002897 Il17ra / Q60943 / Interleukin-17 receptor A / Q96F46*  / complex
 ENSMUSG00000040770 Il25 / interleukin 25 / Q9H293*  / complex






 

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