| MP:0000490 | abnormal crypts of Lieberkuhn morphology | "malformation or defects in the tubular intestinal glands found in the mucosal membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Smn1tm1Jme/Smn1tm1.1Jme,Tg(Eno2-cre)39Jme/0
Genetic Background: involves: 129 * C57BL/6 * SJL
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| MP:0000495 | abnormal colon morphology | "malformation of the portion of the large intestine between the cecum and the rectum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Oca2p-un+6J/Oca2p-un+6J
Genetic Background: C57BL/6J-Oca2p-un
Allelic Composition: Il25tm1Cdon/Il25tm1Cdon,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6N * SJL
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| MP:0001552 | increased circulating triglyceride level | "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416] |
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Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Sprntm1Geno/Sprntm1Geno
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J * FVB/N
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| MP:0001858 | intestinal inflammation | "local accumulation of fluid, plasma proteins, and leukocytes in the intestine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
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Allelic Composition: Smn1tm1Jme/Smn1tm1.1Jme,Tg(Eno2-cre)39Jme/0
Genetic Background: involves: 129 * C57BL/6 * SJL
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| MP:0001861 | lung inflammation | "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
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Allelic Composition: Oca2p-un+6J/Oca2p-un+6J
Genetic Background: C57BL/6J-Oca2p-un
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| MP:0002411 | decreased susceptibility to bacterial infection | "reduced likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Oca2p-un+6J/Oca2p-un+6J
Genetic Background: C57BL/6J-Oca2p-un
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| MP:0002497 | increased IgE | "greater than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Celf4Ff/Celf4Ff
Genetic Background: involves: 129S1/Sv * C57BL/6J
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| MP:0003449 | abnormal intestinal goblet cells | "malformation of the unicellular mucin-secreting glands" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95282] |
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Allelic Composition: Il25tm1Dart/Il25tm1Dart
Genetic Background: C57BL/6-Il25tm1Dart
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| MP:0004799 | increased susceptibility to experimental autoimmune encephalomyelitis | "greater likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Meg3tm1Jvs/Meg3+
Genetic Background: involves: 129P2/OlaHsd
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| MP:0005012 | decreased eosinophil count | "fewer than normal eosinophil numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Celf4Ff/Celf4Ff
Genetic Background: involves: 129S1/Sv * C57BL/6J
Allelic Composition: Il25tm1.1Cdon/Il25tm1.1Cdon
Genetic Background: involves: 129S6/SvEvTac
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| MP:0005015 | increased T cell number | "greater than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Meg3tm1Jvs/Meg3+
Genetic Background: involves: 129P2/OlaHsd
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| MP:0005025 | response to infection | "the body s reaction to invasion and multiplication of microorganisms in its tissues, or the body s reaction to components of or toxins produced by pathogenic mircroorganisms " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Smn1tm1Jme/Smn1tm1.1Jme,Tg(Eno2-cre)39Jme/0
Genetic Background: involves: 129 * C57BL/6 * SJL
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| MP:0005027 | increased susceptibility to parasitic infection | "greater likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Celf4Ff/Celf4Ff
Genetic Background: involves: 129S1/Sv * C57BL/6J
Allelic Composition: Il25tm1Dart/Il25tm1Dart
Genetic Background: C57BL/6-Il25tm1Dart
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| MP:0005232 | abnormal mesenteric lymph node morphology | "anomalous structure, development, or number of the lymph nodes located in the mesentary, of which there are 3 classes: ileocolic, juxtaintestinal mesenteric, and central superior group" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Celf4Ff/Celf4Ff
Genetic Background: involves: 129S1/Sv * C57BL/6J
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| MP:0005596 | increased susceptibility to type I hypersensitvity reaction | "greater likelihood of developing a response manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized; it is IgE-mediated, and mast cell activation and degranulation are hallmarks" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Il25tm1.1Cdon/Il25tm1.1Cdon
Genetic Background: involves: 129S6/SvEvTac
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| MP:0008091 | decreased T-helper 2 cell number | "reduction in the number of the type of T-helper cell whose cytokine production promotes defense against extracellular parasites and humoral immune responses typical of allergy" [CL:0000546, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Il25tm1.1Cdon/Il25tm1.1Cdon
Genetic Background: involves: 129S6/SvEvTac
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| MP:0008496 | decreased IgG2a level | "less than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"] |
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Allelic Composition: Il25tm1Dart/Il25tm1Dart
Genetic Background: C57BL/6-Il25tm1Dart
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| MP:0008539 | decreased susceptibility to induced colitis | "decreased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Il25tm1.1Cdon/Il25tm1.1Cdon
Genetic Background: involves: 129S6/SvEvTac
Allelic Composition: Il25tm1Cdon/Il25tm1Cdon,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6N * SJL
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| MP:0008561 | decreased tumor necrosis factor secretion | "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800] |
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Allelic Composition: Il25tm1.1Cdon/Il25tm1.1Cdon
Genetic Background: involves: 129S6/SvEvTac
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| MP:0008568 | abnormal interleukin secretion | "anomaly in the production or cellular release of soluble factors which stimulate growth-related activities of leukocytes and other cell types, that can act to enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465] |
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Allelic Composition: Celf4Ff/Celf4Ff
Genetic Background: involves: 129S1/Sv * C57BL/6J
Allelic Composition: Il25tm1.1Cdon/Il25tm1.1Cdon
Genetic Background: involves: 129S6/SvEvTac
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| MP:0008658 | decreased interleukin-1 beta secretion | "reduction in the production or release of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600] |
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Allelic Composition: Il25tm1.1Cdon/Il25tm1.1Cdon
Genetic Background: involves: 129S6/SvEvTac
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| MP:0008673 | decreased interleukin-13 secretion | "reduction in the production or release of a cytokine synthesized by T-cells that produces proliferation, immunoglobulin isotype switching, and immunoglobulin production by immature B-cells, and appears to play a role in regulating inflammatory and immune responses" [MESH:D12.644.276.374.465.513] |
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Allelic Composition: Celf4Ff/Celf4Ff
Genetic Background: involves: 129S1/Sv * C57BL/6J
Allelic Composition: Il25tm1.1Cdon/Il25tm1.1Cdon
Genetic Background: involves: 129S6/SvEvTac
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| MP:0008700 | decreased interleukin-4 secretion | "reduction in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504] |
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Allelic Composition: Il25tm1.1Cdon/Il25tm1.1Cdon
Genetic Background: involves: 129S6/SvEvTac
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| MP:0008703 | decreased interleukin-5 secretion | "reduction in the production or release of a cytokine that promotes differentiation and activation of eosinophils; it also triggers activated B-cells to differentiate into immunoglobulin-secreting cells" [MESH:D12.644.276.374.465.505] |
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Allelic Composition: Celf4Ff/Celf4Ff
Genetic Background: involves: 129S1/Sv * C57BL/6J
Allelic Composition: Il25tm1.1Cdon/Il25tm1.1Cdon
Genetic Background: involves: 129S6/SvEvTac
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| MP:0008712 | decreased interleukin-9 secretion | "reduction in the production or release of a multifunctional cytokine secreted by primarily by activated TH2 cells that may play a role as a regulator of allergic inflammation, and has been shown to enhance the growth and differentiation of mast cells, and can act on a variety of other immune cells" [MESH:D12.644.276.374.465.509] |
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Allelic Composition: Il25tm1.1Cdon/Il25tm1.1Cdon
Genetic Background: involves: 129S6/SvEvTac
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| MP:0008722 | abnormal chemokine secretion | "anomaly in the production or cellular release of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200] |
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Allelic Composition: Il25tm1.1Cdon/Il25tm1.1Cdon
Genetic Background: involves: 129S6/SvEvTac
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| MP:0008750 | abnormal interferon level | "deviation from the normal levels of proteins secreted by vertebrate cells in response to a wide variety of inducers; they confer resistance against many different viruses, inhibit proliferation of normal and malignant cells, impede multiplication of intracellular parasites, enhance macrophage and granulocyte phagocytosis, augment natural killer cell activity, and show several other immunomodulatory functions" [MESH:D12.644.276.374.440] |
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Allelic Composition: Il25tm1Dart/Il25tm1Dart
Genetic Background: C57BL/6-Il25tm1Dart
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| MP:0008751 | abnormal interleukin level | "deviation from the normal levels of soluble factors which stimulate growth-related activities of leukocytes as well as other cell types; they enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465] |
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Allelic Composition: Il25tm1Dart/Il25tm1Dart
Genetic Background: C57BL/6-Il25tm1Dart
Allelic Composition: Il25tm1Dart/Il25tm1Dart
Genetic Background: involves: C57BL/6
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| MP:0009763 | increased sensitivity to induced morbidity/mortality | "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Il25tm1Dart/Il25tm1Dart
Genetic Background: involves: C57BL/6
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| MP:0010181 | decreased susceptibility to weight loss | "smaller decrease in body weight over time when compared to the average decrease in weight in response to dietary modification, fasting or caloric restriction" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Il25tm1.1Cdon/Il25tm1.1Cdon
Genetic Background: involves: 129S6/SvEvTac
Allelic Composition: Il25tm1Cdon/Il25tm1Cdon,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6N * SJL
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