| MP:0000222 | decreased neutrophil count | "fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Krt71Rgsc689/?
Genetic Background: involves: C57BL/6J * DBA/2J
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| MP:0001193 | psoriasis | "chronic skin lesions characterized by inflammation and silvery-scaly patches" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Lhx6tm2Vpa/Lhx6tm2Vpa
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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| MP:0001876 | decreased inflammatory response | "less than expected response to injury, infection, or insult" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Krt71Rgsc689/?
Genetic Background: involves: C57BL/6J * DBA/2J
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| MP:0002406 | increased susceptibility to infection | "greater likelihood that an organism will develop ill effects from a pathogenic invasion or from components of or toxins produced by pathogens " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Krt71Rgsc689/?
Genetic Background: involves: C57BL/6J * DBA/2J
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| MP:0003447 | reduced tumor growth/size | "less than expected development of tumorous growth when compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65383] |
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Allelic Composition: Apctm1Tno/Apc+,Il17ratm1Koll/Il17ratm1Koll,Tg(CDX2-cre)101Erf/0
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6J * SJL/J
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| MP:0003828 | pulmonary edema | "an accumulation of an excessive amount of watery fluid in the lung " [J:44108, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator] |
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Allelic Composition: Krt71Rgsc689/?
Genetic Background: involves: C57BL/6J * DBA/2J
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| MP:0004947 | skin inflammation | "local accumulation of fluid, plasma proteins, and leukocytes in the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Lhx6tm2Vpa/Lhx6tm2Vpa
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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| MP:0008074 | increased CD4-positive T cell number | "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Lhx6tm2Vpa/Lhx6tm2Vpa
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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| MP:0008092 | abnormal T-helper 2 cell differentiation | "atypical production of or inability to produce the type of T-helper cell whose cytokine production promotes defense against extracellular parasites and humoral immune responses typical of allergy" [CL:0000546, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Mrdq5C57BL/6/Mrdq5C57BL/6,Rd3rd3/Rd3rd3
Genetic Background: involves: BALB/cByJ * C57BL/6
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| MP:0008111 | abnormal granulocyte differentiaton | "atypical production of or inability to produce leukocytes that have abundant granules in the cytoplasm, including basophils, neutrophils, and eosinophils" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Krt71Rgsc689/?
Genetic Background: involves: C57BL/6J * DBA/2J
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| MP:0008346 | increased gamma-delta T cell number | "greater number of immature or mature T cells expressing an gamma-delta T cell receptor complex" [CL:0000798, ISBN:0781735149] |
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Allelic Composition: Lhx6tm2Vpa/Lhx6tm2Vpa
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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| MP:0008568 | abnormal interleukin secretion | "anomaly in the production or cellular release of soluble factors which stimulate growth-related activities of leukocytes and other cell types, that can act to enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465] |
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Allelic Composition: Lhx6tm2Vpa/Lhx6tm2Vpa
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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| MP:0008671 | abnormal interleukin-13 secretion | "anomaly in the production or release of a cytokine synthesized by T-cells that produces proliferation, immunoglobulin isotype switching, and immunoglobulin production by immature B-cells, and appears to play a role in regulating inflammatory and immune responses" [MESH:D12.644.276.374.465.513] |
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Allelic Composition: Krt71Rgsc689/?
Genetic Background: involves: C57BL/6J * DBA/2J
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| MP:0008681 | increased interleukin-17 secretion | "increase in the production or release of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517] |
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Allelic Composition: Lhx6tm2Vpa/Lhx6tm2Vpa
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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| MP:0008682 | decreased interleukin-17 secretion | "reduction in the production or release of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517] |
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Allelic Composition: Mrdq5C57BL/6/Mrdq5C57BL/6,Rd3rd3/Rd3rd3
Genetic Background: involves: BALB/cByJ * C57BL/6
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| MP:0008701 | abnormal interleukin-5 secretion | "anomaly in the production or release of a cytokine that promotes differentiation and activation of eosinophils; it also triggers activated B-cells to differentiate into immunoglobulin-secreting cells" [MESH:D12.644.276.374.465.505] |
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Allelic Composition: Krt71Rgsc689/?
Genetic Background: involves: C57BL/6J * DBA/2J
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| MP:0008705 | increased interleukin-6 secretion | "increase in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506] |
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Allelic Composition: Lhx6tm2Vpa/Lhx6tm2Vpa
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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| MP:0008712 | decreased interleukin-9 secretion | "reduction in the production or release of a multifunctional cytokine secreted by primarily by activated TH2 cells that may play a role as a regulator of allergic inflammation, and has been shown to enhance the growth and differentiation of mast cells, and can act on a variety of other immune cells" [MESH:D12.644.276.374.465.509] |
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Allelic Composition: Mrdq5C57BL/6/Mrdq5C57BL/6,Rd3rd3/Rd3rd3
Genetic Background: involves: BALB/cByJ * C57BL/6
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| MP:0008719 | impaired neutrophil recruitment | "reduced diffusion or accumulation of neutrophils in tissues or cells in response to a wide variety of substances released at the sites of inflammatory reactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Krt71Rgsc689/?
Genetic Background: involves: C57BL/6J * DBA/2J
Allelic Composition: Il17ratm1Koll/Il17ratm1Koll
Genetic Background: involves: 129
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| MP:0010219 | increased T-helper 17 cell number | "increased number of CD4-positive, alpha-beta T cells with the phenotype RORgamma-t-positive that produces IL-17" [CL:0000899] |
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Allelic Composition: Lhx6tm2Vpa/Lhx6tm2Vpa
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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