ENSMUSG00000043088


Mus musculus

Features
Gene ID: ENSMUSG00000043088
  
Biological name :Il17re
  
Synonyms : Il17re / Interleukin-17 receptor E / Q8BH06
  
Possible biological names infered from orthology : Q8NFR9
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: E3
Gene start: 113458484
Gene end: 113470758
  
Corresponding Affymetrix probe sets: 10540679 (MoGene1.0st)   1426566_s_at (Mouse Genome 430 2.0 Array)   1439357_at (Mouse Genome 430 2.0 Array)   1452109_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000145384
Ensembl peptide - ENSMUSP00000145345
Ensembl peptide - ENSMUSP00000145363
Ensembl peptide - ENSMUSP00000054378
Ensembl peptide - ENSMUSP00000062103
Ensembl peptide - ENSMUSP00000098626
NCBI entrez gene - 57890     See in Manteia.
MGI - MGI:1889371
RefSeq - XM_011241419
RefSeq - NM_001034029
RefSeq - NM_001034031
RefSeq - NM_145826
RefSeq - XM_006506426
RefSeq - XM_011241418
RefSeq Peptide - NP_665825
RefSeq Peptide - NP_001029201
RefSeq Peptide - NP_001029203
swissprot - Q8BH06
swissprot - A0A0N4SW41
Ensembl - ENSMUSG00000043088
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000038663Gallus gallus
 IL17REENSG00000163701Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR013568  SEFIR domain
 IPR027841  Interleukin-17 receptor C/E, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0030368 interleukin-17 receptor activity IBA


Pathways (from Reactome)
Pathway description
Interleukin-17 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001193 psoriasis "chronic skin lesions characterized by inflammation and silvery-scaly patches" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Krastm4Tyj/Kras+
Genetic Background: B6.129S4-Krastm4Tyj

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tnfrsf9em2Ygch/Tnfrsf9em2Ygch
Genetic Background: NOD/ShiLtDvs-Tnfrsf9em2Ygch

 MP:0003449 abnormal intestinal goblet cells "malformation of the unicellular mucin-secreting glands" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95282]
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Allelic Composition: Krastm4Tyj/Kras+
Genetic Background: B6.129S4-Krastm4Tyj

 MP:0003453 abnormal keratinocyte physiology "atypical function of the cells of the epidermis that produce keratin" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:94860]
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Allelic Composition: Krastm4Tyj/Kras+
Genetic Background: B6.129S4-Krastm4Tyj

 MP:0004842 abnormal large intestine crypts of Lieberkuhn morphology "any structural anomaly in the tubular intestinal glands found in the mucosal membranes of the large intestine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Krastm4Tyj/Kras+
Genetic Background: B6.129S4-Krastm4Tyj

 MP:0008537 increased susceptibility to induced colitis "increased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Krastm4Tyj/Kras+
Genetic Background: B6.129S4-Krastm4Tyj

 MP:0009788 increased susceptibility to bacterial infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Tnfrsf9em2Ygch/Tnfrsf9em2Ygch
Genetic Background: NOD/ShiLtDvs-Tnfrsf9em2Ygch

 MP:0010180 increased susceptibility to weight loss "greater decrease in body weight over time when compared to the average decrease in weight in response to dietary modification, fasting or caloric restriction" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Krastm4Tyj/Kras+
Genetic Background: B6.129S4-Krastm4Tyj

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000002897 Il17ra / Q60943 / Interleukin-17 receptor A / Q96F46*  / complex






 

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