ENSMUSG00000041872


Mus musculus

Features
Gene ID: ENSMUSG00000041872
  
Biological name :Il17f
  
Synonyms : Il17f / Interleukin-17F / Q7TNI7
  
Possible biological names infered from orthology : Q96PD4
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: A4
Gene start: 20777146
Gene end: 20790617
  
Corresponding Affymetrix probe sets: 10353415 (MoGene1.0st)   1442462_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000140122
Ensembl peptide - ENSMUSP00000046960
NCBI entrez gene - 257630     See in Manteia.
MGI - MGI:2676631
RefSeq - NM_145856
RefSeq - XM_006495523
RefSeq Peptide - NP_665855
swissprot - A0A087WQB4
swissprot - Q7TNI7
Ensembl - ENSMUSG00000041872
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 il17a/f1ENSDARG00000043933Danio rerio
 il17a/f3ENSDARG00000041976Danio rerio
 ENSGALG00000016677Gallus gallus
 IL17AENSGALG00000016678Gallus gallus
 IL17FENSG00000112116Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Il17a / Q62386 / Interleukin-17A / Q16552*ENSMUSG0000002592947


Protein motifs (from Interpro)
Interpro ID Name
 IPR010345  Interleukin-17 family
 IPR020440  Interleukin-17, chordata
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0016525 negative regulation of angiogenesis IEA
 biological_processGO:0017015 regulation of transforming growth factor beta receptor signaling pathway IEA
 biological_processGO:0042089 cytokine biosynthetic process IEA
 biological_processGO:0042109 lymphotoxin A biosynthetic process IEA
 biological_processGO:0045076 regulation of interleukin-2 biosynthetic process IEA
 biological_processGO:0045408 regulation of interleukin-6 biosynthetic process IEA
 biological_processGO:0045414 regulation of interleukin-8 biosynthetic process IEA
 biological_processGO:0045423 regulation of granulocyte macrophage colony-stimulating factor biosynthetic process IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IGI
 biological_processGO:0051216 cartilage development IEA
 biological_processGO:1900017 positive regulation of cytokine production involved in inflammatory response IGI
 biological_processGO:2000778 positive regulation of interleukin-6 secretion IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0005126 cytokine receptor binding IPI
 molecular_functionGO:0019955 cytokine binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA


Pathways (from Reactome)
Pathway description
Interleukin-17 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: KitlSl-J/Kitl+
Genetic Background: C3HeB/FeHu-KitlSl-J

 MP:0001866 nasal inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the proximal portion of the respiratory passages " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Il17atm1Yiw/Il17atm1Yiw,Il17ftm1Yiw/Il17ftm1Yiw,Il1rntm1Yiw/Il1rntm1Yiw
Genetic Background: involves: 129 * BALB/c

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nodaltm1.1Mku/Nodaltm2Mku,Tg(T-cre)1Lwd/0
Genetic Background: involves: 129S1/Sv * C3H * C57BL/6

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il17atm1Yiw/Il17atm1Yiw,Il17ftm1Yiw/Il17ftm1Yiw,Il1rntm1Yiw/Il1rntm1Yiw
Genetic Background: involves: 129 * BALB/c

Allelic Composition: Il17ftm1Yiw/Il17ftm1Yiw
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Il17atm1Yiw/Il17atm1Yiw,Il17ftm1Yiw/Il17ftm1Yiw
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002435 abnormal effector T cell morphology/development "anomalous structure, formation, or numbers of the set of T lymphocytes that are able to respond immediately upon contact with cells bearing the appropriate peptide:MHC complex for the cell" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il17a/Il17ftm1.1Impr/Il17a/Il17ftm1.1Impr
Genetic Background: involves: C57BL/6

 MP:0002499 chronic inflammation "persistent inflammatory response, often caused by persistent infection or during an autoimmune response" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Il17atm1Cdon/Il17atm1Cdon
Genetic Background: involves: C57BL/6

 MP:0002742 enlarged submandibular lymph nodes "increased size of the submandibular lymph nodes" [J:69405, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Il17atm1Yiw/Il17atm1Yiw,Il17ftm1Yiw/Il17ftm1Yiw,Il1rntm1Yiw/Il1rntm1Yiw
Genetic Background: involves: 129 * BALB/c

Allelic Composition: Il17atm1Yiw/Il17atm1Yiw,Il17ftm2Yiw/Il17ftm2Yiw
Genetic Background: B6.129P2-Il17atm1Yiw Il17ftm2Yiw

 MP:0003561 rheumatoid arthritis "an autoimmune disease that causes chronic inflammation of the joints and may also cause inflammation of the tissue around the joints, as well as other organs in the body" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Il17ftm1Yiw/Il17ftm1Yiw,Il1rntm1Yiw/Il1rntm1Yiw
Genetic Background: involves: 129 * BALB/c

Allelic Composition: Il17atm1Yiw/Il17atm1Yiw,Il17ftm1Yiw/Il17ftm1Yiw,Il1rntm1Yiw/Il1rntm1Yiw
Genetic Background: involves: 129 * BALB/c

 MP:0003747 mouth mucosal ulceration "lesions through the mucous membrane of the mouth" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Il17atm1Yiw/Il17atm1Yiw,Il17ftm1Yiw/Il17ftm1Yiw,Il1rntm1Yiw/Il1rntm1Yiw
Genetic Background: involves: 129 * BALB/c

 MP:0004800 decreased susceptibility to experimental autoimmune encephalomyelitis "reduced likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il17atm1Cdon/Il17atm1Cdon
Genetic Background: involves: C57BL/6

 MP:0005087 reduced acute inflammation "less than the expected early reaction of the microcirculation, characterized by movement of fluid and leukocytes from the blood into extravascular tissues; initiated by injury, infection, or local immune response " [Pathology:ISBN 0-397-51047-0, J:74478]
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Allelic Composition: Il17atm1Cdon/Il17atm1Cdon
Genetic Background: involves: C57BL/6

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il17a/Il17ftm1.1Impr/Il17a/Il17ftm1.1Impr
Genetic Background: involves: C57BL/6

 MP:0008346 increased gamma-delta T cell number "greater number of immature or mature T cells expressing an gamma-delta T cell receptor complex" [CL:0000798, ISBN:0781735149]
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Allelic Composition: Il17a/Il17ftm1.1Impr/Il17a/Il17ftm1.1Impr
Genetic Background: involves: C57BL/6

 MP:0008348 absent gamma-delta T cells "absence of immature or mature T cells expressing an gamma-delta T cell receptor complex" [CL:0000798, ISBN:0781735149]
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Allelic Composition: Il17a/Il17ftm1.1Impr/Il17a/Il17ftm1.1Impr
Genetic Background: involves: C57BL/6

 MP:0008498 decreased IgG3 level "less than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Il17atm1Yiw/Il17atm1Yiw,Il17ftm1Yiw/Il17ftm1Yiw,Il1rntm1Yiw/Il1rntm1Yiw
Genetic Background: involves: 129 * BALB/c

Allelic Composition: Il17atm1Yiw/Il17atm1Yiw,Il17ftm2Yiw/Il17ftm2Yiw
Genetic Background: B6.129P2-Il17atm1Yiw Il17ftm2Yiw

 MP:0008499 increased IgG1 level "greater than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Il17atm1Yiw/Il17atm1Yiw,Il17ftm1Yiw/Il17ftm1Yiw,Il1rntm1Yiw/Il1rntm1Yiw
Genetic Background: involves: 129 * BALB/c

Allelic Composition: Il17atm1Yiw/Il17atm1Yiw,Il17ftm2Yiw/Il17ftm2Yiw
Genetic Background: B6.129P2-Il17atm1Yiw Il17ftm2Yiw

 MP:0008500 increased IgG2a level "greater than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Il17atm1Cdon/Il17atm1Cdon
Genetic Background: involves: C57BL/6

Allelic Composition: Il17atm1Yiw/Il17atm1Yiw,Il17ftm2Yiw/Il17ftm2Yiw
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Il17atm1Yiw/Il17atm1Yiw,Il17ftm2Yiw/Il17ftm2Yiw
Genetic Background: B6.129P2-Il17atm1Yiw Il17ftm2Yiw

 MP:0008501 increased IgG2b level "greater than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Il17atm1Yiw/Il17atm1Yiw,Il17ftm2Yiw/Il17ftm2Yiw
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Il17atm1Yiw/Il17atm1Yiw,Il17ftm2Yiw/Il17ftm2Yiw
Genetic Background: B6.129P2-Il17atm1Yiw Il17ftm2Yiw

 MP:0008539 decreased susceptibility to induced colitis "decreased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il17atm1Cdon/Il17atm1Cdon
Genetic Background: involves: C57BL/6

 MP:0008682 decreased interleukin-17 secretion "reduction in the production or release of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517]
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Allelic Composition: Il17atm1Cdon/Il17atm1Cdon
Genetic Background: involves: C57BL/6

Allelic Composition: Il17ftm1Awai/Il17ftm1Awai
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Il17ftm1Awai/Il17f+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Il17a/Il17ftm1.1Impr/Il17a/Il17ftm1.1Impr
Genetic Background: involves: C57BL/6

 MP:0009787 increased susceptibility to infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a pathogenic invasion or from components of or toxins produced by pathogens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Il17atm1Yiw/Il17atm1Yiw,Il17ftm2Yiw/Il17ftm2Yiw
Genetic Background: B6.129P2-Il17atm1Yiw Il17ftm2Yiw

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000025929 Il17a / Q62386 / Interleukin-17A / Q16552*  / complex
 ENSMUSG00000030281 Il17rc / Q8K4C2 / Interleukin-17 receptor C / Q8NAC3*  / complex
 ENSMUSG00000041872 Il17f / Q7TNI7 / Interleukin-17F / Q96PD4*  / complex
 ENSMUSG00000002897 Il17ra / Q60943 / Interleukin-17 receptor A / Q96F46*  / complex






 

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