ENSMUSG00000030281


Mus musculus

Features
Gene ID: ENSMUSG00000030281
  
Biological name :Il17rc
  
Synonyms : Il17rc / Interleukin-17 receptor C / Q8K4C2
  
Possible biological names infered from orthology : Q8NAC3
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: E3
Gene start: 113471427
Gene end: 113483140
  
Corresponding Affymetrix probe sets: 10540705 (MoGene1.0st)   1419671_a_at (Mouse Genome 430 2.0 Array)   1457471_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000145420
Ensembl peptide - ENSMUSP00000055343
Ensembl peptide - ENSMUSP00000145038
Ensembl peptide - ENSMUSP00000145348
NCBI entrez gene - 171095     See in Manteia.
MGI - MGI:2159336
RefSeq - NM_178942
RefSeq - XM_006505666
RefSeq - XM_006505665
RefSeq - NM_134159
RefSeq Peptide - NP_598920
RefSeq Peptide - NP_849273
swissprot - F7AR97
swissprot - Q8K4C2
swissprot - A0A0N4SW88
swissprot - F6ZF00
Ensembl - ENSMUSG00000030281
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FO904970.1ENSDARG00000105863Danio rerio
 il17rcENSDARG00000099902Danio rerio
 IL17RCENSG00000163702Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR013568  SEFIR domain
 IPR027841  Interleukin-17 receptor C/E, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0019221 cytokine-mediated signaling pathway IEA
 biological_processGO:0050832 defense response to fungus IMP
 biological_processGO:0071621 granulocyte chemotaxis IMP
 biological_processGO:1900017 positive regulation of cytokine production involved in inflammatory response IGI
 biological_processGO:2000778 positive regulation of interleukin-6 secretion IMP
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005102 signaling receptor binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030368 interleukin-17 receptor activity IEA


Pathways (from Reactome)
Pathway description
Interleukin-17 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001876 decreased inflammatory response "less than expected response to injury, infection, or insult" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il17rbtm1Lex/Il17rbtm1Lex
Genetic Background: C.129-Il17rbtm1Lex

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Taglntm1Liw/Taglntm1Liw
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004800 decreased susceptibility to experimental autoimmune encephalomyelitis "reduced likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il17rbtm1Lex/Il17rbtm1Lex
Genetic Background: C.129-Il17rbtm1Lex

 MP:0008681 increased interleukin-17 secretion "increase in the production or release of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517]
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Allelic Composition: Il17rbtm1Lex/Il17rbtm1Lex
Genetic Background: C.129-Il17rbtm1Lex

 MP:0008721 abnormal chemokine level "deviation from the normal levels of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200]
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Allelic Composition: Il17rbtm1Lex/Il17rbtm1Lex
Genetic Background: C.129-Il17rbtm1Lex

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000025929 Il17a / Q62386 / Interleukin-17A / Q16552*  / complex
 ENSMUSG00000041872 Il17f / Q7TNI7 / Interleukin-17F / Q96PD4*  / complex
 ENSMUSG00000002897 Il17ra / Q60943 / Interleukin-17 receptor A / Q96F46*  / complex






 

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