ENSMUSG00000018334


Mus musculus

Features
Gene ID: ENSMUSG00000018334
  
Biological name :Ksr1
  
Synonyms : Ksr1 / Mus musculus kinase suppressor of ras 1 (Ksr1), transcript variant 2, mRNA. / Q61097
  
Possible biological names infered from orthology : kinase suppressor of ras 1 / Q8IVT5
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: B5
Gene start: 79013440
Gene end: 79146407
  
Corresponding Affymetrix probe sets: 10388914 (MoGene1.0st)   1419823_s_at (Mouse Genome 430 2.0 Array)   1442581_at (Mouse Genome 430 2.0 Array)   1450114_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000146527
Ensembl peptide - ENSMUSP00000146491
Ensembl peptide - ENSMUSP00000154385
Ensembl peptide - ENSMUSP00000018478
Ensembl peptide - ENSMUSP00000103899
Ensembl peptide - ENSMUSP00000114538
Ensembl peptide - ENSMUSP00000116407
NCBI entrez gene - 16706     See in Manteia.
MGI - MGI:105051
RefSeq - XM_011248775
RefSeq - XM_006532335
RefSeq - XM_006532336
RefSeq - XM_006532338
RefSeq - XM_011248770
RefSeq - XM_011248771
RefSeq - XM_011248772
RefSeq - XM_011248773
RefSeq - XM_011248774
RefSeq - NM_001348207
RefSeq - NM_013571
RefSeq - XM_006532334
RefSeq Peptide - NP_038599
RefSeq Peptide - NP_001335136
swissprot - A0A140LHP4
swissprot - Q5SXE1
swissprot - Q5SXE2
swissprot - A0A140LHS5
swissprot - Q5SXE4
swissprot - Q61097
Ensembl - ENSMUSG00000018334
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ksr1aENSDARG00000068714Danio rerio
 ksr1bENSDARG00000030933Danio rerio
 KSR1ENSGALG00000005685Gallus gallus
 KSR1ENSG00000141068Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ksr2 / kinase suppressor of ras 2 / Q6VAB6*ENSMUSG0000006157851
Braf / P28028 / Serine/threonine-protein kinase B-raf / P15056* / B-Raf proto-oncogene, serine/threonine kinase*ENSMUSG0000000241321
Raf1 / Q99N57 / Mus musculus v-raf-leukemia viral onco 1 (Raf1), transcript variant 3, mRNA. / P04049* / Raf-1 proto-oncogene, serine/threonine kinase*ENSMUSG0000000044118
Araf / P04627 / Serine/threonine-protein kinase A-Raf / P10398* / A-Raf proto-oncogene, serine/threonine kinase*ENSMUSG0000000112718


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR025561  Kinase suppressor of RAS, SAM-like domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007265 Ras protein signal transduction IMP
 biological_processGO:0019933 cAMP-mediated signaling IMP
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0043410 positive regulation of MAPK cascade IDA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IBA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IBA
 cellular_componentGO:0032587 ruffle membrane IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IBA
 molecular_functionGO:0005078 MAP-kinase scaffold activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0031434 mitogen-activated protein kinase kinase binding IPI
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051087 chaperone binding IPI
 molecular_functionGO:0051879 Hsp90 protein binding IPI
 molecular_functionGO:0071889 14-3-3 protein binding IPI


Pathways (from Reactome)
Pathway description
RAF activation
MAP2K and MAPK activation
Negative regulation of MAPK pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Sema3ftm1.1Ddg/Sema3ftm1.2Ddg,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0000377 abnormal hair follicle "malformed invagination of the epidermis from which the hair shaft develops" [J:65031]
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Allelic Composition: Sema3ftm1.1Ddg/Sema3ftm1.2Ddg,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0000379 reduced hair follicle number "fewer number of the epidermal invaginations from which the hair shaft develops" [J:15108]
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Allelic Composition: Sema3ftm1.1Ddg/Sema3ftm1.2Ddg,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0000383 abnormal hair follicle orientation "misaligned hair follicles; hair follicles that do not orient in a typical pattern" [J:47620]
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Allelic Composition: Sema3ftm1.1Ddg/Sema3ftm1.2Ddg,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0000414 alopecia "absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796]
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Allelic Composition: Sema3ftm1.1Ddg/Sema3ftm1.2Ddg,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0000416 sparse fur "fur that is significantly less dense" [J:46854]
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Allelic Composition: Sema3ftm1.1Ddg/Sema3ftm1.2Ddg,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0000427 abnormal hair cycle "aberrant growth or asynchronous timing of the hair growth " [J:65302]
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Allelic Composition: Sema3ftm1.1Ddg/Sema3ftm1.2Ddg,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0001208 blistering "accumulation of fluid- filled thin walled structures under the epidermis or within the epidermis" [J:65039]
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Allelic Composition: Sema3ftm1.1Ddg/Sema3ftm1.2Ddg,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Btlatm1Kmm/Btlatm1Kmm,Tg(DO11.10)10Dlo/?
Genetic Background: involves: 129S/SvEv * BALB/c * C3H * C57BL/6

 MP:0001900 impaired synaptic plasticity "decreased or inability of the nervous system to change its reactivity as a result of successive activations " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Btlatm1Kmm/Btlatm1Kmm,Tg(DO11.10)10Dlo/?
Genetic Background: involves: 129S/SvEv * BALB/c * C3H * C57BL/6

 MP:0002063 abnormal learning/memory/conditioning "altered ability to receive, store or recall informational stimuli" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Btlatm1Kmm/Btlatm1Kmm,Tg(DO11.10)10Dlo/?
Genetic Background: involves: 129S/SvEv * BALB/c * C3H * C57BL/6

 MP:0003436 resistance to induced arthritis "less likely to be striken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:75303]
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Allelic Composition: Btlatm1Kmm/Btlatm1Kmm,Tg(DO11.10)10Dlo/?
Genetic Background: involves: 129S/SvEv * BALB/c * C3H * C57BL/6

 MP:0003704 abnormal hair follicle development "anomalous development of the epidermis from which the hair shaft develops " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Sema3ftm1.1Ddg/Sema3ftm1.2Ddg,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0003809 abnormal hair shaft morphology "irregular or unusual structure of the cuticle, and/or cortex and/or medulla of a hair" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Sema3ftm1.1Ddg/Sema3ftm1.2Ddg,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0004502 decreased incidence of chemically-induced tumors "lower than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Sema3ftm1.1Ddg/Sema3ftm1.2Ddg,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0005076 abnormal cell differentiation "anomaly in the process whereby relatively unspecialized cells, e. g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism s life history" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ksr1tm1Shaw/Ksr1tm1Shaw,Tg(DO11.10)10Dlo/0
Genetic Background: involves: BALB/c * C3H * C57BL/6

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Btlatm1Kmm/Btlatm1Kmm,Tg(DO11.10)10Dlo/?
Genetic Background: involves: 129S/SvEv * BALB/c * C3H * C57BL/6

Allelic Composition: Ksr1tm1Shaw/Ksr1tm1Shaw,Tg(DO11.10)10Dlo/0
Genetic Background: involves: BALB/c * C3H * C57BL/6

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sema3ftm1.1Ddg/Sema3ftm1.2Ddg,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0006094 adipocyte hypertrophy "increase in the size of fat cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:90802]
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Allelic Composition: Ksr1tm1Shaw/Ksr1tm1Shaw,Tg(DO11.10)10Dlo/0
Genetic Background: involves: BALB/c * C3H * C57BL/6

 MP:0008076 abnormal CD4-positive T cell differentiation "atypical production of or inability to produce the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ksr1tm1Shaw/Ksr1tm1Shaw,Tg(DO11.10)10Dlo/0
Genetic Background: involves: BALB/c * C3H * C57BL/6

 MP:0008414 abnormal spatial reference memory "anomaly in the ability to recall spatial location information from previous encounters or training sessions in order to naviagate or perform other behavior using such locational cues" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Btlatm1Kmm/Btlatm1Kmm,Tg(DO11.10)10Dlo/?
Genetic Background: involves: 129S/SvEv * BALB/c * C3H * C57BL/6

 MP:0008688 decreased interleukin-2 secretion "reduction in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
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Allelic Composition: Ksr1tm1Shaw/Ksr1tm1Shaw,Tg(DO11.10)10Dlo/0
Genetic Background: involves: BALB/c * C3H * C57BL/6

 MP:0009131 decreased white fat cell number "reduction in the number of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ksr1tm1Shaw/Ksr1tm1Shaw,Tg(DO11.10)10Dlo/0
Genetic Background: involves: BALB/c * C3H * C57BL/6

 MP:0009454 impaired contextual conditioning "decrease in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and the neutral, unchanging environment (the conditioned stimulus (CS), or the environmental context in this case)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Btlatm1Kmm/Btlatm1Kmm,Tg(DO11.10)10Dlo/?
Genetic Background: involves: 129S/SvEv * BALB/c * C3H * C57BL/6

 MP:0009456 impaired cued conditioning behavior "decrease in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and a neutral stimulus (the conditioned stimulus (CS), usually an auditory cue or light flash)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Btlatm1Kmm/Btlatm1Kmm,Tg(DO11.10)10Dlo/?
Genetic Background: involves: 129S/SvEv * BALB/c * C3H * C57BL/6

 MP:0009828 delayed tumor appearance "later onset of tumor occurence than expected, but with expected incidence" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
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Allelic Composition: Ksr1tm1Shaw/Ksr1tm1Shaw,Tg(DO11.10)10Dlo/0
Genetic Background: involves: BALB/c * C3H * C57BL/6

 MP:0010685 abnormal hair follicle inner root sheath morphology "any structural anomaly of the multilayered tube composed of terminally differentiated hair follicle keratinocytes that is surrounded by the outer root sheath; the layers of the inner root sheath include the companion layer, Henle s layer, Huxley s layer and the inner root sheath cuticle" [PMID:19211055]
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Allelic Composition: Sema3ftm1.1Ddg/Sema3ftm1.2Ddg,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000441 Raf1 / Q99N57 / Mus musculus v-raf-leukemia viral onco 1 (Raf1), transcript variant 3, mRNA. / P04049* / Raf-1 proto-oncogene, serine/threonine kinase*  / reaction / complex
 ENSMUSG00000002413 Braf / P28028 / Serine/threonine-protein kinase B-raf / P15056* / B-Raf proto-oncogene, serine/threonine kinase*  / complex / reaction
 ENSMUSG00000004936 Map2k1 / P31938 / Dual specificity mitogen-activated protein kinase kinase 1 / Q02750* / mitogen-activated protein kinase kinase 1*  / reaction / complex
 ENSMUSG00000018326 Ywhab / Q9CQV8 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide / P31946* / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta*  / complex / reaction
 ENSMUSG00000007411 Mark3 / Q03141 / MAP/microtubule affinity-regulating kinase 3 / P27448* / microtubule affinity regulating kinase 3*  / complex
 ENSMUSG00000030265 Kras / P32883 / GTPase KRas GTPase KRas, N-terminally processed / P01116* / KRAS proto-oncogene, GTPase*  / reaction / complex
 ENSMUSG00000025499 Hras / Q61411 / GTPase HRas GTPase HRas, N-terminally processed / P01112* / HRas proto-oncogene, GTPase*  / complex / reaction
 ENSMUSG00000029458 Brap / Q99MP8 / BRCA1-associated protein / Q7Z569*  / reaction / complex
 ENSMUSG00000063358 Mapk1 / P63085 / Mus musculus mitogen-activated protein kinase 1 (Mapk1), transcript variant 3, mRNA. / P28482* / mitogen-activated protein kinase 1*  / complex / reaction
 ENSMUSG00000063065 Mapk3 / Q63844 / Mitogen-activated protein kinase 3 / P27361*  / reaction / complex
 ENSMUSG00000035027 Q63932 / Map2k2 / Mus musculus mitogen-activated protein kinase kinase 2 (Map2k2), transcript variant 2, mRNA. / P36507* / AC011005.1* / mitogen-activated protein kinase kinase 2*  / complex / reaction






 

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