ENSMUSG00000001127


Mus musculus

Features
Gene ID: ENSMUSG00000001127
  
Biological name :Araf
  
Synonyms : Araf / P04627 / Serine/threonine-protein kinase A-Raf
  
Possible biological names infered from orthology : A-Raf proto-oncogene, serine/threonine kinase / P10398
  
Species: Mus musculus
  
Chr. number: X
Strand: 1
Band: A1.3
Gene start: 20797814
Gene end: 20860519
  
Corresponding Affymetrix probe sets: 10598956 (MoGene1.0st)   1426602_at (Mouse Genome 430 2.0 Array)   1428607_at (Mouse Genome 430 2.0 Array)   1435566_s_at (Mouse Genome 430 2.0 Array)   1440764_at (Mouse Genome 430 2.0 Array)   1445693_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000115793
Ensembl peptide - ENSMUSP00000112521
Ensembl peptide - ENSMUSP00000119544
Ensembl peptide - ENSMUSP00000114846
Ensembl peptide - ENSMUSP00000001155
Ensembl peptide - ENSMUSP00000112513
NCBI entrez gene - 11836     See in Manteia.
MGI - MGI:88065
RefSeq - XM_006527557
RefSeq - XM_006527556
RefSeq - XM_011247429
RefSeq - NM_001159645
RefSeq - NM_009703
RefSeq - XM_011247430
RefSeq Peptide - NP_033833
RefSeq Peptide - NP_001153117
swissprot - Q8CAD1
swissprot - P04627
swissprot - E9Q0P8
swissprot - B1AUN8
swissprot - B1AUP0
Ensembl - ENSMUSG00000001127
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 arafENSDARG00000054533Danio rerio
 ARAFENSG00000078061Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Raf1 / Q99N57 / Mus musculus v-raf-leukemia viral onco 1 (Raf1), transcript variant 3, mRNA. / P04049* / Raf-1 proto-oncogene, serine/threonine kinase*ENSMUSG0000000044161
Braf / P28028 / Serine/threonine-protein kinase B-raf / P15056* / B-Raf proto-oncogene, serine/threonine kinase*ENSMUSG0000000241358
Ksr1 / Q61097 / Mus musculus kinase suppressor of ras 1 (Ksr1), transcript variant 2, mRNA. / Q8IVT5* / kinase suppressor of ras 1*ENSMUSG0000001833425
Ksr2 / kinase suppressor of ras 2 / Q6VAB6*ENSMUSG0000006157825


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR003116  Raf-like Ras-binding
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR020454  Diacylglycerol/phorbol-ester binding
 IPR029071  Ubiquitin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IEA
 biological_processGO:0000186 activation of MAPKK activity IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007275 multicellular organism development IBA
 biological_processGO:0009968 negative regulation of signal transduction IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0020021 immortalization of host cell IDA
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0032006 regulation of TOR signaling ISS
 biological_processGO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation ISO
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0043066 negative regulation of apoptotic process IBA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IBA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity ISO
 molecular_functionGO:0004709 MAP kinase kinase kinase activity IEA
 molecular_functionGO:0005057 obsolete signal transducer activity, downstream of receptor IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0031434 mitogen-activated protein kinase kinase binding IBA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
RAF activation
MAP2K and MAPK activation
Negative regulation of MAPK pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000492 abnormal rectum morphology "structural aberration in the terminal portion of the intestinal tube adjacent to the anus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Aqp3tm1Ask/Aqp3tm1Ask,Aqp4tm1Ask/Aqp4tm1Ask
Genetic Background: involves: C57BL/6J

Allelic Composition: Araftm1Mmc/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000706 small thymus "reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]
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Allelic Composition: Aqp3tm1Ask/Aqp3tm1Ask,Aqp4tm1Ask/Aqp4tm1Ask
Genetic Background: involves: C57BL/6J

Allelic Composition: Araftm1Mmc/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Aqp3tm1Ask/Aqp3tm1Ask,Aqp4tm1Ask/Aqp4tm1Ask
Genetic Background: involves: C57BL/6J

Allelic Composition: Araftm1Mmc/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000746 weakness "state of being infirm or less strong than littermates" [J:45400]
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Allelic Composition: Aqp3tm1Ask/Aqp3tm1Ask,Aqp4tm1Ask/Aqp4tm1Ask
Genetic Background: involves: C57BL/6J

Allelic Composition: Araftm1Mmc/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Aqp3tm1Ask/Aqp3tm1Ask,Aqp4tm1Ask/Aqp4tm1Ask
Genetic Background: involves: C57BL/6J

Allelic Composition: Araftm1Mmc/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Aqp3tm1Ask/Aqp3tm1Ask,Aqp4tm1Ask/Aqp4tm1Ask
Genetic Background: involves: C57BL/6J

Allelic Composition: Araftm1Mmc/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001362 abnormal anxiety-related response "altered emotional response related to anticipation of a non-specific threat" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, CFG:Center for Functional Genomics, Northwestern University]
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Allelic Composition: Aqp3tm1Ask/Aqp3tm1Ask,Aqp4tm1Ask/Aqp4tm1Ask
Genetic Background: involves: C57BL/6J

Allelic Composition: Araftm1Mmc/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001436 abnormal suckling behavior "reduced ability or inability to exert suction by the mouth, or atypical suckling pattern" [J:16461]
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Allelic Composition: Aqp3tm1Ask/Aqp3tm1Ask,Aqp4tm1Ask/Aqp4tm1Ask
Genetic Background: involves: C57BL/6J

Allelic Composition: Araftm1Mmc/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Aqp3tm1Ask/Aqp3tm1Ask,Aqp4tm1Ask/Aqp4tm1Ask
Genetic Background: involves: C57BL/6J

Allelic Composition: Araftm1Mmc/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001516 abnormal motor coordination/ balance "altered ability of an animal to maintain skillful and effective interaction of movements or maintenance of equilibrium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Aqp3tm1Ask/Aqp3tm1Ask,Aqp4tm1Ask/Aqp4tm1Ask
Genetic Background: involves: C57BL/6J

Allelic Composition: Araftm1Mmc/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001527 athetotic walking movements "characterized by slow, writhing involuntary movements of flexion, extension, pronation and supination of the paws and toes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:18984]
Show

Allelic Composition: Aqp3tm1Ask/Aqp3tm1Ask,Aqp4tm1Ask/Aqp4tm1Ask
Genetic Background: involves: C57BL/6J

Allelic Composition: Araftm1Mmc/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002108 abnormal muscle morphology "abnormal development of muscle tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Aqp3tm1Ask/Aqp3tm1Ask,Aqp4tm1Ask/Aqp4tm1Ask
Genetic Background: involves: C57BL/6J

Allelic Composition: Araftm1Mmc/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002731 megacolon "extreme dilation of the colon" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:40722]
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Allelic Composition: Aqp3tm1Ask/Aqp3tm1Ask,Aqp4tm1Ask/Aqp4tm1Ask
Genetic Background: involves: C57BL/6J

Allelic Composition: Araftm1Mmc/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004263 abnormal limb posture "atypical position of the limbs compared to the normal carriage of the body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Aqp3tm1Ask/Aqp3tm1Ask,Aqp4tm1Ask/Aqp4tm1Ask
Genetic Background: involves: C57BL/6J

Allelic Composition: Araftm1Mmc/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Aqp3tm1Ask/Aqp3tm1Ask,Aqp4tm1Ask/Aqp4tm1Ask
Genetic Background: involves: C57BL/6J

Allelic Composition: Araftm1Mmc/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000025499 Hras / Q61411 / GTPase HRas GTPase HRas, N-terminally processed / P01112* / HRas proto-oncogene, GTPase*  / complex / reaction
 ENSMUSG00000018326 Ywhab / Q9CQV8 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide / P31946* / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta*  / complex / reaction
 ENSMUSG00000030265 Kras / P32883 / GTPase KRas GTPase KRas, N-terminally processed / P01116* / KRAS proto-oncogene, GTPase*  / reaction / complex
 ENSMUSG00000002413 Braf / P28028 / Serine/threonine-protein kinase B-raf / P15056* / B-Raf proto-oncogene, serine/threonine kinase*  / complex / reaction
 ENSMUSG00000055725 Paqr3 / Q6TCG8 / progestin and adipoQ receptor family member III / Q6TCH7* / progestin and adipoQ receptor family member 3*  / reaction / complex






 

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