ENSG00000078061


Homo sapiens

Features
Gene ID: ENSG00000078061
  
Biological name :ARAF
  
Synonyms : ARAF / A-Raf proto-oncogene, serine/threonine kinase / P10398
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: X
Strand: 1
Band: p11.3
Gene start: 47561100
Gene end: 47571920
  
Corresponding Affymetrix probe sets: 201895_at (Human Genome U133 Plus 2.0 Array)   230652_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000366244
Ensembl peptide - ENSP00000290277
Ensembl peptide - ENSP00000366238
NCBI entrez gene - 369     See in Manteia.
OMIM - 311010
RefSeq - XM_011543909
RefSeq - NM_001256196
RefSeq - NM_001256197
RefSeq - NM_001654
RefSeq - XM_006724529
RefSeq - XM_011543906
RefSeq - XM_011543908
RefSeq Peptide - NP_001243125
RefSeq Peptide - NP_001243126
RefSeq Peptide - NP_001645
swissprot - P10398
swissprot - Q96II5
swissprot - A0A024R178
Ensembl - ENSG00000078061
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 arafENSDARG00000054533Danio rerio
 ArafENSMUSG00000001127Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RAF1 / P04049 / Raf-1 proto-oncogene, serine/threonine kinaseENSG0000013215561
BRAF / P15056 / B-Raf proto-oncogene, serine/threonine kinaseENSG0000015776459
KSR1 / Q8IVT5 / kinase suppressor of ras 1ENSG0000014106826
KSR2 / Q6VAB6 / kinase suppressor of ras 2ENSG0000017143525


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR003116  Raf-like Ras-binding
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR020454  Diacylglycerol/phorbol-ester binding
 IPR029071  Ubiquitin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IEA
 biological_processGO:0000186 activation of MAPKK activity IEA
 biological_processGO:0006464 cellular protein modification process TAS
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007275 multicellular organism development IBA
 biological_processGO:0009968 negative regulation of signal transduction IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0020021 immortalization of host cell IEA
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0032006 regulation of TOR signaling IMP
 biological_processGO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IDA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0043066 negative regulation of apoptotic process IDA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IBA
 cellular_componentGO:0005575 cellular_component ND
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004709 MAP kinase kinase kinase activity IEA
 molecular_functionGO:0005057 obsolete signal transducer activity, downstream of receptor IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0031434 mitogen-activated protein kinase kinase binding IBA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
RAF activation
MAP2K and MAPK activation
Negative regulation of MAPK pathway
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by RAS mutants
Signaling by BRAF and RAF fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000174775 HRAS / P01112 / HRas proto-oncogene, GTPase  / reaction / complex
 ENSG00000213281 NRAS / P01111 / NRAS proto-oncogene, GTPase  / reaction / complex
 ENSG00000157764 BRAF / P15056 / B-Raf proto-oncogene, serine/threonine kinase  / reaction / complex
 ENSG00000133703 KRAS / P01116 / KRAS proto-oncogene, GTPase  / complex / reaction
 ENSG00000166913 YWHAB / P31946 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta  / complex / reaction
 ENSG00000163291 PAQR3 / Q6TCH7 / progestin and adipoQ receptor family member 3  / complex / reaction






 

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