ENSG00000171435


Homo sapiens

Features
Gene ID: ENSG00000171435
  
Biological name :KSR2
  
Synonyms : kinase suppressor of ras 2 / KSR2 / Q6VAB6
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: -1
Band: q24.23
Gene start: 117453012
Gene end: 117968983
  
Corresponding Affymetrix probe sets: 1553491_at (Human Genome U133 Plus 2.0 Array)   230551_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000389715
Ensembl peptide - ENSP00000339952
NCBI entrez gene - 283455     See in Manteia.
OMIM - 610737
RefSeq - XM_017019210
RefSeq - NM_173598
RefSeq - XM_011538228
RefSeq - XM_011538229
RefSeq - XM_017019208
RefSeq - XM_011538224
RefSeq - XM_011538225
RefSeq - XM_011538226
RefSeq Peptide - NP_775869
swissprot - Q6VAB6
swissprot - E9PB13
Ensembl - ENSG00000171435
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ksr2ENSDARG00000094526Danio rerio
 si:ch73-263f13.1ENSDARG00000094172Danio rerio
 KSR2ENSGALG00000020905Gallus gallus
 Ksr2ENSMUSG00000061578Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
KSR1 / Q8IVT5 / kinase suppressor of ras 1ENSG0000014106844
BRAF / P15056 / B-Raf proto-oncogene, serine/threonine kinaseENSG0000015776419
RAF1 / P04049 / Raf-1 proto-oncogene, serine/threonine kinaseENSG0000013215517
ARAF / P10398 / A-Raf proto-oncogene, serine/threonine kinaseENSG0000007806117


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR025561  Kinase suppressor of RAS, SAM-like domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0019722 calcium-mediated signaling IBA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0043410 positive regulation of MAPK cascade IBA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IBA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
MAP2K and MAPK activation
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by RAS mutants
Signaling by BRAF and RAF fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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