Manteia - Molecule gene

ENSMUSG00000071369

Mus musculus

Features

Gene ID:	ENSMUSG00000071369

Biological name :	Map3k5

Synonyms :	Map3k5 / Mitogen-activated protein kinase kinase kinase 5 / O35099

Possible biological names infered from orthology :	Q99683

Species:	Mus musculus

Chr. number:	10
Strand:	1
Band:	A3
Gene start:	19934472
Gene end:	20142753

Corresponding Affymetrix probe sets:	10361926 (MoGene1.0st) 1421340_at (Mouse Genome 430 2.0 Array) 1439830_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000093485 Ensembl peptide - ENSMUSP00000150155 Ensembl peptide - ENSMUSP00000122553 Ensembl peptide - ENSMUSP00000114518 Ensembl peptide - ENSMUSP00000112864 NCBI entrez gene - 26408 See in Manteia. MGI - MGI:1346876 RefSeq - XM_006512739 RefSeq - NM_008580 RefSeq Peptide - NP_032606 swissprot - A0A1L1ST18 swissprot - D3Z5H1 swissprot - E9PWG9 swissprot - O35099 swissprot - D3YVC4 Ensembl - ENSMUSG00000071369

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
map3k5	ENSDARG00000005416	Danio rerio
MAP3K5	ENSGALG00000013892	Gallus gallus
MAP3K5	ENSG00000197442	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
A2AQW0 / Map3k15 / Mitogen-activated protein kinase kinase kinase 15 / Q6ZN16*	ENSMUSG00000031303	54
Map3k6 / mitogen-activated protein kinase kinase kinase 6 / O95382*	ENSMUSG00000028862	43

Protein motifs (from Interpro)

Interpro ID	Name
IPR000719	Protein kinase domain
IPR008271	Serine/threonine-protein kinase, active site
IPR011009	Protein kinase-like domain superfamily
IPR013761	Sterile alpha motif/pointed domain superfamily
IPR017441	Protein kinase, ATP binding site
IPR025136	Domain of unknown function DUF4071

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000165	MAPK cascade	IEA
biological_process	GO:0000186	activation of MAPKK activity	IEA
biological_process	GO:0000187	activation of MAPK activity	IDA
biological_process	GO:0001934	positive regulation of protein phosphorylation	IEA
biological_process	GO:0002376	immune system process	IEA
biological_process	GO:0002931	response to ischemia	IEA
biological_process	GO:0006468	protein phosphorylation	IEA
biological_process	GO:0006915	apoptotic process	IEA
biological_process	GO:0007254	JNK cascade	IEA
biological_process	GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress	IEA
biological_process	GO:0010666	positive regulation of cardiac muscle cell apoptotic process	IEA
biological_process	GO:0010941	regulation of cell death	IGI
biological_process	GO:0016310	phosphorylation	IEA
biological_process	GO:0034198	cellular response to amino acid starvation	IEA
biological_process	GO:0034976	response to endoplasmic reticulum stress	IMP
biological_process	GO:0038066	p38MAPK cascade	IEP
biological_process	GO:0042060	wound healing	IEA
biological_process	GO:0043065	positive regulation of apoptotic process	IEA
biological_process	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	IEA
biological_process	GO:0043507	positive regulation of JUN kinase activity	IEA
biological_process	GO:0045087	innate immune response	IEA
biological_process	GO:0045663	positive regulation of myoblast differentiation	IDA
biological_process	GO:0045893	positive regulation of transcription, DNA-templated	IEA
biological_process	GO:0046330	positive regulation of JNK cascade	IMP
biological_process	GO:0051403	stress-activated MAPK cascade	IEA
biological_process	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IMP
biological_process	GO:0070301	cellular response to hydrogen peroxide	IEA
biological_process	GO:0071356	cellular response to tumor necrosis factor	IEA
biological_process	GO:0072577	endothelial cell apoptotic process	IEA
biological_process	GO:0097300	programmed necrotic cell death	IMP
biological_process	GO:1900745	positive regulation of p38MAPK cascade	IEA
biological_process	GO:1901216	positive regulation of neuron death	IMP
biological_process	GO:1902170	cellular response to reactive nitrogen species	IMP
biological_process	GO:1904707	positive regulation of vascular smooth muscle cell proliferation	IEA
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0005783	endoplasmic reticulum	IEA
cellular_component	GO:0005829	cytosol	IEA
cellular_component	GO:0009897	external side of plasma membrane	IEA
cellular_component	GO:0032991	protein-containing complex	IEA
cellular_component	GO:1902911	protein kinase complex	IEA
cellular_component	GO:1990604	IRE1-TRAF2-ASK1 complex	IEA
molecular_function	GO:0000166	nucleotide binding	IEA
molecular_function	GO:0000287	magnesium ion binding	IEA
molecular_function	GO:0004672	protein kinase activity	IEA
molecular_function	GO:0004674	protein serine/threonine kinase activity	IEA
molecular_function	GO:0004709	MAP kinase kinase kinase activity	ISO
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0005524	ATP binding	IEA
molecular_function	GO:0016301	kinase activity	IEA
molecular_function	GO:0016740	transferase activity	IEA
molecular_function	GO:0019901	protein kinase binding	IPI
molecular_function	GO:0019903	protein phosphatase binding	IEA
molecular_function	GO:0019904	protein domain specific binding	IEA
molecular_function	GO:0042802	identical protein binding	IEA
molecular_function	GO:0042803	protein homodimerization activity	IEA
molecular_function	GO:0046872	metal ion binding	IEA

Pathways (from Reactome)

Pathway description

Oxidative Stress Induced Senescence

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000343	altered response to myocardial infarction	"change in the physiological response to necrosis of the cardiac tissue, often resulting from the sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Fmn1^tm1.1Zlr/Fmn1^tm1.1Zlr Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0004486	decreased response of heart to induced stress	"decrease in severity of the physiological response of the heart to induced stress such as cardiac hypertrophy due to mechanical pressure overload from aortic banding" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fmn1^tm1.1Zlr/Fmn1^tm1.1Zlr Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0008874	decreased sensitivity to xenobiotics	"increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fmn1^tm1.1Zlr/Fmn1^tm1.1Zlr Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Map3k5^tm1Hijo/Map3k5^tm1Hijo,Map3k6^tm1Hijo/Map3k6^tm1Hijo Genetic Background: B6.129-Map3k6^tm1Hijo Map3k5^tm1Hijo
MP:0008944	decreased sensitivity to induced cell death	"increase in the exposure level to an agent that is required to induce cessation of function at the cellular level" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fmn1^tm1.1Zlr/Fmn1^tm1.1Zlr Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000020623	Map2k6 / P70236 / mitogen-activated protein kinase kinase 6 / P52564*	/ reaction
ENSMUSG00000028367	Txn1 / P10639 / thioredoxin 1 / TXN* / P10599* / thioredoxin*	/ complex
ENSMUSG00000018932	Map2k3 / O09110 / mitogen-activated protein kinase kinase 3 / P46734*	/ reaction

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr