ENSMUSG00000028862


Mus musculus

Features
Gene ID: ENSMUSG00000028862
  
Biological name :Map3k6
  
Synonyms : Map3k6 / mitogen-activated protein kinase kinase kinase 6
  
Possible biological names infered from orthology : O95382
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: D2.3
Gene start: 133240818
Gene end: 133252929
  
Corresponding Affymetrix probe sets: 10508829 (MoGene1.0st)   1449901_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000030677
NCBI entrez gene - 53608     See in Manteia.
MGI - MGI:1855691
RefSeq - NM_016693
RefSeq - XM_006539040
RefSeq Peptide - NP_057902
swissprot - A0A0A0MQ82
Ensembl - ENSMUSG00000028862
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:ch211-1i11.3ENSDARG00000104760Danio rerio
 MAP3K6ENSG00000142733Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Map3k5 / O35099 / Mitogen-activated protein kinase kinase kinase 5 / Q99683*ENSMUSG0000007136945
A2AQW0 / Map3k15 / Mitogen-activated protein kinase kinase kinase 15 / Q6ZN16*ENSMUSG0000003130344


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR013761  Sterile alpha motif/pointed domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR025136  Domain of unknown function DUF4071


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IEA
 biological_processGO:0000186 activation of MAPKK activity IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0016310 phosphorylation IEA
 cellular_componentGO:0005622 intracellular IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004709 MAP kinase kinase kinase activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0004499 increased incidence of chemically-induced tumors "higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Krt71Ca-d/Krt71+
Genetic Background: involves: 101/H * C3H/HeH

Allelic Composition: Map3k6tm1Hijo/Map3k6+
Genetic Background: B6.129P2-Map3k6tm1Hijo

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Krt71Ca-d/Krt71+
Genetic Background: involves: 101/H * C3H/HeH

Allelic Composition: Map3k5tm1Hijo/Map3k5tm1Hijo,Map3k6tm1Hijo/Map3k6tm1Hijo
Genetic Background: B6.129-Map3k6tm1Hijo Map3k5tm1Hijo

 MP:0009581 decreased keratinocyte apoptosis "reduction in the number of keratinocytes undergoing programmed cell death" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Krt71Ca-d/Krt71+
Genetic Background: involves: 101/H * C3H/HeH

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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