ENSG00000142733


Homo sapiens

Features
Gene ID: ENSG00000142733
  
Biological name :MAP3K6
  
Synonyms : MAP3K6 / mitogen-activated protein kinase kinase kinase 6 / O95382
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: p36.11
Gene start: 27355184
Gene end: 27366892
  
Corresponding Affymetrix probe sets: 1552631_a_at (Human Genome U133 Plus 2.0 Array)   219278_at (Human Genome U133 Plus 2.0 Array)   229960_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000363152
Ensembl peptide - ENSP00000418932
Ensembl peptide - ENSP00000419591
Ensembl peptide - ENSP00000350195
Ensembl peptide - ENSP00000418731
NCBI entrez gene - 9064     See in Manteia.
OMIM - 604468
RefSeq - XM_017002772
RefSeq - NM_001297609
RefSeq - NM_004672
RefSeq - XM_017002771
RefSeq Peptide - NP_001284538
RefSeq Peptide - NP_004663
swissprot - H0Y8A3
swissprot - O95382
swissprot - H0Y894
Ensembl - ENSG00000142733
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:ch211-1i11.3ENSDARG00000104760Danio rerio
 Map3k6ENSMUSG00000028862Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MAP3K5 / Q99683 / mitogen-activated protein kinase kinase kinase 5ENSG0000019744246
Q6ZN16 / MAP3K15 / mitogen-activated protein kinase kinase kinase 15ENSG0000018081544


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR013761  Sterile alpha motif/pointed domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR025136  Domain of unknown function DUF4071


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000186 activation of MAPKK activity IEA
 biological_processGO:0006468 protein phosphorylation IDA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007257 activation of JUN kinase activity TAS
 biological_processGO:0016310 phosphorylation IEA
 cellular_componentGO:0005622 intracellular IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding IDA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004709 MAP kinase kinase kinase activity TAS
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IDA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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