ENSG00000197442


Homo sapiens

Features
Gene ID: ENSG00000197442
  
Biological name :MAP3K5
  
Synonyms : MAP3K5 / mitogen-activated protein kinase kinase kinase 5 / Q99683
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: -1
Band: q23.3
Gene start: 136557047
Gene end: 136792518
  
Corresponding Affymetrix probe sets: 203836_s_at (Human Genome U133 Plus 2.0 Array)   203837_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000351908
NCBI entrez gene - 4217     See in Manteia.
OMIM - 602448
RefSeq - XM_017010877
RefSeq - NM_005923
RefSeq - XM_017010875
RefSeq - XM_017010876
RefSeq - XM_011535839
RefSeq - XM_017010870
RefSeq - XM_017010871
RefSeq - XM_017010872
RefSeq - XM_017010873
RefSeq - XM_017010874
RefSeq Peptide - NP_005914
swissprot - Q99683
Ensembl - ENSG00000197442
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 map3k5ENSDARG00000005416Danio rerio
 MAP3K5ENSGALG00000013892Gallus gallus
 Map3k5ENSMUSG00000071369Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q6ZN16 / MAP3K15 / mitogen-activated protein kinase kinase kinase 15ENSG0000018081556
MAP3K6 / O95382 / mitogen-activated protein kinase kinase kinase 6ENSG0000014273343


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR013761  Sterile alpha motif/pointed domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR025136  Domain of unknown function DUF4071


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade TAS
 biological_processGO:0000186 activation of MAPKK activity IDA
 biological_processGO:0000187 activation of MAPK activity IEA
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002931 response to ischemia IEA
 biological_processGO:0006468 protein phosphorylation IDA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007254 JNK cascade IDA
 biological_processGO:0007257 activation of JUN kinase activity TAS
 biological_processGO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress IEA
 biological_processGO:0010666 positive regulation of cardiac muscle cell apoptotic process IEA
 biological_processGO:0010941 regulation of cell death IEA
 biological_processGO:0016032 viral process IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0034198 cellular response to amino acid starvation IDA
 biological_processGO:0034976 response to endoplasmic reticulum stress IEA
 biological_processGO:0038066 p38MAPK cascade IEA
 biological_processGO:0042060 wound healing IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
 biological_processGO:0043507 positive regulation of JUN kinase activity IMP
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045663 positive regulation of myoblast differentiation IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0046330 positive regulation of JNK cascade IEA
 biological_processGO:0051403 stress-activated MAPK cascade IDA
 biological_processGO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IEA
 biological_processGO:0070301 cellular response to hydrogen peroxide IDA
 biological_processGO:0071356 cellular response to tumor necrosis factor IEA
 biological_processGO:0072577 endothelial cell apoptotic process IEA
 biological_processGO:0097190 apoptotic signaling pathway TAS
 biological_processGO:0097300 programmed necrotic cell death IEA
 biological_processGO:1900745 positive regulation of p38MAPK cascade IEA
 biological_processGO:1901216 positive regulation of neuron death IEA
 biological_processGO:1902170 cellular response to reactive nitrogen species IEA
 biological_processGO:1904707 positive regulation of vascular smooth muscle cell proliferation IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0009897 external side of plasma membrane IEA
 cellular_componentGO:0032991 protein-containing complex IMP
 cellular_componentGO:1902911 protein kinase complex IDA
 cellular_componentGO:1990604 IRE1-TRAF2-ASK1 complex IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding IDA
 molecular_functionGO:0004672 protein kinase activity IDA
 molecular_functionGO:0004674 protein serine/threonine kinase activity TAS
 molecular_functionGO:0004709 MAP kinase kinase kinase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IDA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0019903 protein phosphatase binding IPI
 molecular_functionGO:0019904 protein domain specific binding IPI
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IDA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Oxidative Stress Induced Senescence


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000065559 MAP2K4 / P45985 / mitogen-activated protein kinase kinase 4  / reaction
 ENSG00000108984 MAP2K6 / P52564 / mitogen-activated protein kinase kinase 6  / reaction
 ENSG00000034152 MAP2K3 / P46734 / mitogen-activated protein kinase kinase 3  / reaction
 ENSG00000136810 TXN / P10599 / thioredoxin  / complex






 

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