4217


Homo sapiens (NCBI)

Features
Gene ID: 4217
  
Biological name :
  
Synonyms : ASK1|MAPKKK5|MEKK5 / MAP3K5 / mitogen-activated protein kinase kinase kinase 5
  
Possible biological names infered from orthology :
  
Species: Homo sapiens (NCBI)
  
Chr. number:
Strand:
Band:
Gene start:
Gene end:
  
Corresponding Affymetrix probe sets: 203836_s_at (Human Genome U133 Plus 2.0 Array)   203837_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: RefSeq - 1034650303
RefSeq - 1034650305
RefSeq - 1034650307
RefSeq - 1034650309
RefSeq - 1034650311
RefSeq - 1034650313
RefSeq - 1034650315
RefSeq - 1034650317
RefSeq - 1034650319
RefSeq - 5174547
RefSeq - NC_000006.12
RefSeq - NG_011965.1
RefSeq - NP_005914.1
RefSeq - XP_011534141.2
RefSeq - XP_016866359.1
RefSeq - XP_016866360.1
RefSeq - XP_016866361.1
RefSeq - XP_016866362.1
RefSeq - XP_016866363.1
RefSeq - XP_016866364.1
RefSeq - XP_016866365.1
RefSeq - XP_016866366.1
RefSeq - NM_005923.3
RefSeq - XM_017010877.1
RefSeq - XM_011535839.3
RefSeq - XM_017010870.1
RefSeq - XM_017010871.1
RefSeq - XM_017010872.1
RefSeq - XM_017010873.1
RefSeq - XM_017010874.1
RefSeq - XM_017010875.1
RefSeq - XM_017010876.1
  
See co-cited genes in PubMed
Warning: Please see the Ensembl gene model ENSG00000197442 to get all the annotations available for this gene.


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IDA
 biological_processGO:0000186 activation of MAPKK activity IDA
 biological_processGO:0002931 response to ischemia IEA
 biological_processGO:0006468 protein phosphorylation IDA
 biological_processGO:0007254 JNK cascade IDA
 biological_processGO:0007257 activation of JUN kinase activity TAS
 biological_processGO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress IDA
 biological_processGO:0010666 positive regulation of cardiac muscle cell apoptotic process IEA
 biological_processGO:0016032 viral process IEA
 biological_processGO:0034198 cellular response to amino acid starvation IDA
 biological_processGO:0034976 response to endoplasmic reticulum stress IMP
 biological_processGO:0038066 p38MAPK cascade IEA
 biological_processGO:0042060 wound healing IEA
 biological_processGO:0043065 positive regulation of apoptotic process IDA
 biological_processGO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
 biological_processGO:0043507 positive regulation of JUN kinase activity IMP
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045663 positive regulation of myoblast differentiation IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0046330 positive regulation of JNK cascade ISS
 biological_processGO:0051403 stress-activated MAPK cascade IDA
 biological_processGO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress ISS
 biological_processGO:0070301 cellular response to hydrogen peroxide IDA
 biological_processGO:0071356 cellular response to tumor necrosis factor IEA
 biological_processGO:0072577 endothelial cell apoptotic process IEA
 biological_processGO:0097190 apoptotic signaling pathway TAS
 biological_processGO:0097300 programmed necrotic cell death IEA
 biological_processGO:1900745 positive regulation of p38MAPK cascade IEA
 biological_processGO:1901216 positive regulation of neuron death ISS
 biological_processGO:1902170 cellular response to reactive nitrogen species IEA
 biological_processGO:1904707 positive regulation of vascular smooth muscle cell proliferation IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0009897 external side of plasma membrane IEA
 cellular_componentGO:0032991 protein-containing complex IMP
 cellular_componentGO:1902911 protein kinase complex IDA
 cellular_componentGO:1990604 IRE1-TRAF2-ASK1 complex IDA
 molecular_functionGO:0000287 magnesium ion binding IDA
 molecular_functionGO:0004672 protein kinase activity IDA
 molecular_functionGO:0004674 protein serine/threonine kinase activity TAS
 molecular_functionGO:0004709 MAP kinase kinase kinase activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IDA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0019903 protein phosphatase binding IPI
 molecular_functionGO:0019904 protein domain specific binding IPI
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IDA


Pathways (from Reactome)
Pathway description
No match


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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