ENSDARG00000005416


Danio rerio

Features
Gene ID: ENSDARG00000005416
  
Biological name :map3k5
  
Synonyms : map3k5 / mitogen-activated protein kinase kinase kinase 5
  
Possible biological names infered from orthology : O35099 / Q99683
  
Species: Danio rerio
  
Chr. number: 20
Strand: -1
Band:
Gene start: 3005472
Gene end: 3087162
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000126631
Ensembl peptide - ENSDARP00000046640
NCBI entrez gene - 555703     See in Manteia.
RefSeq - NM_001161750
RefSeq - XM_021468422
RefSeq Peptide - NP_001155222
swissprot - R4GDS5
swissprot - E7F2L3
ZFIN ID - ZDB-GENE-030827-3
Ensembl - ENSDARG00000005416
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MAP3K5ENSGALG00000013892Gallus gallus
 MAP3K5ENSG00000197442Homo sapiens
 Map3k5ENSMUSG00000071369Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
map3k15 / mitogen-activated protein kinase kinase kinase 15 / A2AQW0* / Q6ZN16*ENSDARG0000001331055
si:ch211-1i11.3 / MAP3K6* / O95382* / mitogen-activated protein kinase kinase kinase 6*ENSDARG0000010476050


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR013761  Sterile alpha motif/pointed domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR025136  Domain of unknown function DUF4071


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IEA
 biological_processGO:0000186 activation of MAPKK activity IBA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0016310 phosphorylation IEA
 cellular_componentGO:0005575 cellular_component ND
 cellular_componentGO:0005622 intracellular IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004709 MAP kinase kinase kinase activity IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
Oxidative Stress Induced Senescence


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000031435 zgc:56493 / TXN* / Txn1* / Q6A555* / Q86VQ3* / P10639* / Q69AB2* / TXNDC2* / TXNDC8* / P10599* / thioredoxin* / thioredoxin 1* / thioredoxin domain containing 2* / thioredoxin domain contai...  / complex
 ENSDARG00000099184 map2k6 / Q9DGE0 / mitogen-activated protein kinase kinase 6 / P52564*  / reaction
 ENSDARG00000044125 txn / thioredoxin / Txn1* / Q6A555* / Q86VQ3* / TXNDC8* / P10599* / P10639* / Q69AB2* / TXNDC2* / thioredoxin 1* / thioredoxin domain containing 2* / thioredoxin domain containing 8* / thio...  / complex






 

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