ENSDARG00000031435


Danio rerio

Features
Gene ID: ENSDARG00000031435
  
Biological name :zgc:56493
  
Synonyms : zgc:56493
  
Possible biological names infered from orthology : P10599 / P10639 / Q69AB2 / Q6A555 / Q86VQ3 / thioredoxin / thioredoxin 1 / thioredoxin domain containing 2 / thioredoxin domain containing 2 (spermatozoa) / thioredoxin domain containing 8 / TXN / Txn1 / TXNDC2 / TXNDC8
  
Species: Danio rerio
  
Chr. number: 1
Strand: 1
Band:
Gene start: 40263671
Gene end: 40270561
  
Corresponding Affymetrix probe sets: Dr.12439.1.S1_at (Zebrafish Array)   NM_200023_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000045696
NCBI entrez gene - 336637     See in Manteia.
RefSeq - NM_200023
RefSeq Peptide - NP_956317
swissprot - Q7ZUI4
ZFIN ID - ZDB-GENE-030131-8581
Ensembl - ENSDARG00000031435
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TXNENSGALG00000015704Gallus gallus
 Q6A555ENSG00000204193Homo sapiens
 Q86VQ3ENSG00000168454Homo sapiens
 TXNENSG00000136810Homo sapiens
 Q69AB2ENSMUSG00000038709Mus musculus
 Txn1ENSMUSG00000028367Mus musculus
 Txndc2ENSMUSG00000050612Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
txn / thioredoxin / Txn1* / Q6A555* / Q86VQ3* / TXNDC8* / P10599* / P10639* / Q69AB2* / TXNDC2* / thioredoxin 1* / thioredoxin domain containing 2* / thioredoxin domain containing 8* / thio...ENSDARG0000004412572
txnl1 / thioredoxin-like 1 / O43396* / Q8CDN6*ENSDARG0000001192140


Protein motifs (from Interpro)
Interpro ID Name
 IPR005746  Thioredoxin
 IPR012336  Thioredoxin-like fold
 IPR013766  Thioredoxin domain
 IPR017937  Thioredoxin, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006662 glycerol ether metabolic process IEA
 biological_processGO:0034599 cellular response to oxidative stress IBA
 biological_processGO:0045454 cell redox homeostasis IBA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0098869 cellular oxidant detoxification IEA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0004791 thioredoxin-disulfide reductase activity IBA
 molecular_functionGO:0015035 protein disulfide oxidoreductase activity IBA
 molecular_functionGO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor IBA
 molecular_functionGO:0047134 protein-disulfide reductase activity IBA


Pathways (from Reactome)
Pathway description
Oxidative Stress Induced Senescence
Detoxification of Reactive Oxygen Species
Interconversion of nucleotide di- and triphosphates
TP53 Regulates Metabolic Genes
Protein repair
The NLRP3 inflammasome


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000014017 rrm1 / ribonucleotide reductase M1 polypeptide / P07742* / P23921* / ribonucleotide reductase catalytic subunit M1* / Ribonucleoside-diphosphate reductase large subunit *  / reaction
 ENSDARG00000018459 msrb2 / methionine sulfoxide reductase B2 / Q78J03* / Q9Y3D2* / Methionine-R-sulfoxide reductase B2, mitochondrial *  / reaction
 ENSDARG00000020711 rrm2 / P79733 / ribonucleotide reductase M2 polypeptide / P31350* / P11157* / AC007240.1* / ribonucleotide reductase regulatory subunit M2* / Ribonucleoside-diphosphate reductase subunit M2 *  / reaction
 ENSDARG00000036107 txnipa / thioredoxin interacting protein a / TXNIP* / Q8BG60* / Q9H3M7* / thioredoxin interacting protein*  / complex / reaction
 ENSDARG00000005416 map3k5 / mitogen-activated protein kinase kinase kinase 5 / O35099* / Q99683*  / complex
 ENSDARG00000025350 prdx2 / peroxiredoxin 2 / Gm5225* / P32119* / Q61171*  / reaction
 ENSDARG00000033367 rrm2b / ribonucleotide reductase M2 b / Q7LG56* / Q6PEE3* / ribonucleotide reductase regulatory TP53 inducible subunit M2B* / Mus musculus ribonucleotide reductase M2 B (TP53 inducible) (Rr...  / reaction
 ENSDARG00000029587 msra / methionine sulfoxide reductase A / Q9D6Y7* / Q9UJ68* / Mitochondrial peptide methionine sulfoxide reductase *  / reaction
 ENSDARG00000045658 msrb3 / methionine sulfoxide reductase B3 / Q8IXL7*  / reaction
 ENSDARG00000058734 prdx1 / peroxiredoxin 1 / P35700* / Q06830*  / reaction
 ENSDARG00000070000 txnipb / thioredoxin interacting protein b / TXNIP* / Q8BG60* / Q9H3M7* / thioredoxin interacting protein*  / complex / reaction
 ENSDARG00000025436 msrb1a / Q802G6 / methionine sulfoxide reductase B1a / MSRB1* / Q9NZV6* / Q9JLC3* / methionine sulfoxide reductase B1* / Mus musculus methionine sulfoxide reductase B1 (Msrb1), transcript v...  / reaction
 ENSDARG00000055064 prdx5 / peroxiredoxin 5 / P30044*  / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr