ENSGALG00000015704


Gallus gallus

Features
Gene ID: ENSGALG00000015704
  
Biological name :TXN
  
Synonyms : P08629 / Thioredoxin / TXN
  
Possible biological names infered from orthology : P10599 / P10639 / Q86VQ3 / thioredoxin 1 / thioredoxin domain containing 2 / thioredoxin domain containing 2 (spermatozoa) / Txn1 / TXNDC2
  
Species: Gallus gallus
  
Chr. number: Z
Strand: -1
Band:
Gene start: 66519578
Gene end: 66525077
  
Corresponding Affymetrix probe sets: Gga.4041.1.S1_a_at (Chicken Array)   Gga.8723.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000025280
NCBI entrez gene - 396437     See in Manteia.
RefSeq - NM_205453
RefSeq Peptide - NP_990784
swissprot - P08629
Ensembl - ENSGALG00000015704
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 txnENSDARG00000044125Danio rerio
 zgc:56493ENSDARG00000031435Danio rerio
 Q86VQ3ENSG00000168454Homo sapiens
 TXNENSG00000136810Homo sapiens
 Txn1ENSMUSG00000028367Mus musculus
 Txndc2ENSMUSG00000050612Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TXNL1 / thioredoxin like 1 / O43396* / Q8CDN6*ENSGALG0000003386238


Protein motifs (from Interpro)
Interpro ID Name
 IPR005746  Thioredoxin
 IPR012336  Thioredoxin-like fold
 IPR013766  Thioredoxin domain
 IPR017937  Thioredoxin, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006662 glycerol ether metabolic process IEA
 biological_processGO:0009314 response to radiation ISS
 biological_processGO:0033158 regulation of protein import into nucleus, translocation ISS
 biological_processGO:0034599 cellular response to oxidative stress IBA
 biological_processGO:0043388 positive regulation of DNA binding ISS
 biological_processGO:0045454 cell redox homeostasis IBA
 biological_processGO:0055114 oxidation-reduction process ISS
 biological_processGO:0098869 cellular oxidant detoxification IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0004791 thioredoxin-disulfide reductase activity IBA
 molecular_functionGO:0015035 protein disulfide oxidoreductase activity IBA
 molecular_functionGO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor IBA
 molecular_functionGO:0047134 protein-disulfide reductase activity IBA


Pathways (from Reactome)
Pathway description
Oxidative Stress Induced Senescence
Detoxification of Reactive Oxygen Species
Interconversion of nucleotide di- and triphosphates
TP53 Regulates Metabolic Genes
Protein repair
The NLRP3 inflammasome


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000005414 MSRB1 / methionine-R-sulfoxide reductase B1 isoform 1 / Q9JLC3* / Q9NZV6* / methionine sulfoxide reductase B1* / Mus musculus methionine sulfoxide reductase B1 (Msrb1), transcript variant 2, mRNA.*  / reaction
 ENSGALG00000017350 RRM1 / ribonucleoside-diphosphate reductase large subunit / P07742* / P23921* / ribonucleotide reductase catalytic subunit M1*  / reaction
 ENSGALG00000016442 RRM2* / P31350* / P11157* / AC007240.1* / ribonucleotide reductase regulatory subunit M2* / Ribonucleoside-diphosphate reductase subunit M2 *  / reaction
 ENSGALG00000013892 MAP3K5 / mitogen-activated protein kinase kinase kinase 5 / O35099* / Q99683*  / complex
 ENSGALG00000010243 PRDX1 / P0CB50 / Peroxiredoxin-1 / P35700* / Q06830*  / reaction
 ENSGALG00000028032 MSRA / methionine sulfoxide reductase A / Q9D6Y7* / Q9UJ68* / Mitochondrial peptide methionine sulfoxide reductase *  / reaction
 ENSGALG00000026661 MSRB3 / methionine sulfoxide reductase B3 / Q8IXL7*  / reaction
 ENSGALG00000040921 RRM2B / ribonucleotide reductase regulatory TP53 inducible subunit M2B / Q6PEE3* / Q7LG56* / Mus musculus ribonucleotide reductase M2 B (TP53 inducible) (Rrm2b), transcript variant 3, mRNA.*  / reaction






 

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