ENSMUSG00000050612


Mus musculus

Features
Gene ID: ENSMUSG00000050612
  
Biological name :Txndc2
  
Synonyms : thioredoxin domain containing 2 (spermatozoa) / Txndc2
  
Possible biological names infered from orthology : Q86VQ3 / thioredoxin domain containing 2
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: E1.1
Gene start: 65637505
Gene end: 65642204
  
Corresponding Affymetrix probe sets: 10452480 (MoGene1.0st)   1437266_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000054909
NCBI entrez gene - 213272     See in Manteia.
MGI - MGI:2389312
RefSeq - XM_011246354
RefSeq - NM_001146002
RefSeq - NM_153519
RefSeq - XM_006523986
RefSeq Peptide - NP_705739
RefSeq Peptide - NP_001139474
swissprot - H7BX21
Ensembl - ENSMUSG00000050612
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 txnENSDARG00000044125Danio rerio
 zgc:56493ENSDARG00000031435Danio rerio
 TXNENSGALG00000015704Gallus gallus
 Q86VQ3ENSG00000168454Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Txn1 / P10639 / thioredoxin 1 / TXN* / P10599* / thioredoxin*ENSMUSG0000002836711
Q69AB2 / Txndc8 / thioredoxin domain containing 8 / Q6A555*ENSMUSG0000003870910
Txnl1 / Q8CDN6 / thioredoxin-like 1 / O43396*ENSMUSG000000245837


Protein motifs (from Interpro)
Interpro ID Name
 IPR005746  Thioredoxin
 IPR013766  Thioredoxin domain
 IPR036249  Thioredoxin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006662 glycerol ether metabolic process IEA
 biological_processGO:0045454 cell redox homeostasis IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005623 cell IEA
 molecular_functionGO:0015035 protein disulfide oxidoreductase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001257 increased body length "increased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Casp9tm1Flv/Casp9tm1Flv
Genetic Background: B6.129S1-Casp9tm1Flv

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Casp9tm1Flv/Casp9tm1Flv
Genetic Background: B6.129S1-Casp9tm1Flv

 MP:0001264 increased body size "larger than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
Show

Allelic Composition: Casp9tm1Flv/Casp9tm1Flv
Genetic Background: B6.129S1-Casp9tm1Flv

 MP:0001565 abnormal circulating phosphate level "anomalous blood concentrations of this salt or ester of phosphoric acid; often associated with anomalous bone mineralization " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Casp9tm1Flv/Casp9tm1Flv
Genetic Background: B6.129S1-Casp9tm1Flv

 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mapttm1(Sema3e)Yuyo/Mapt+,Olig2tm1(cre)Tmj/Olig2+
Genetic Background: Not Specified

 MP:0003674 oxidative stress "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Mapttm1(Sema3e)Yuyo/Mapt+,Olig2tm1(cre)Tmj/Olig2+
Genetic Background: Not Specified

 MP:0004543 abnormal sperm physiology "anomaly in the normal function of spermatozoa" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Mapttm1(Sema3e)Yuyo/Mapt+,Olig2tm1(cre)Tmj/Olig2+
Genetic Background: Not Specified

 MP:0008058 abnormal DNA repair "any anomaly in the process of restoring DNA after damage or replication error" [GO:0006281]
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Allelic Composition: Mapttm1(Sema3e)Yuyo/Mapt+,Olig2tm1(cre)Tmj/Olig2+
Genetic Background: Not Specified

 MP:0008597 decreased circulating interleukin-6 level "reduction in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: Casp9tm1Flv/Casp9tm1Flv
Genetic Background: B6.129S1-Casp9tm1Flv

 MP:0012582 increased peroxidase activity "increased ability to catalyze the reaction: donor + hydrogen peroxide = oxidized donor + 2 H2O" [GO:0004601, http://orcid.org/0000-0001-5208-3432]
Show

Allelic Composition: Mapttm1(Sema3e)Yuyo/Mapt+,Olig2tm1(cre)Tmj/Olig2+
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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