ENSG00000114738


Homo sapiens

Features
Gene ID: ENSG00000114738
  
Biological name :MAPKAPK3
  
Synonyms : MAPKAPK3 / mitogen-activated protein kinase-activated protein kinase 3 / Q16644
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: 1
Band: p21.2
Gene start: 50611520
Gene end: 50649297
  
Corresponding Affymetrix probe sets: 202787_s_at (Human Genome U133 Plus 2.0 Array)   202788_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000410970
Ensembl peptide - ENSP00000394894
Ensembl peptide - ENSP00000478922
Ensembl peptide - ENSP00000396467
Ensembl peptide - ENSP00000402045
Ensembl peptide - ENSP00000350639
NCBI entrez gene - 7867     See in Manteia.
OMIM - 602130
RefSeq - NM_004635
RefSeq - NM_001243925
RefSeq - NM_001243926
RefSeq Peptide - NP_001230854
RefSeq Peptide - NP_001230855
RefSeq Peptide - NP_004626
swissprot - Q16644
swissprot - C9J8E1
swissprot - A0A024R2W7
swissprot - H7C0G6
swissprot - C9JPW3
Ensembl - ENSG00000114738
  
Related genetic diseases (OMIM): 617111 - ?Macular dystrophy, patterned, 3, 617111
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mapkapk3ENSDARG00000111612Danio rerio
 MAPKAPK3ENSGALG00000002283Gallus gallus
 Q3UMW7ENSMUSG00000032577Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P49137 / MAPKAPK2 / mitogen-activated protein kinase-activated protein kinase 2ENSG0000016288968
Q8IW41 / MAPKAPK5 / mitogen-activated protein kinase-activated protein kinase 5ENSG0000008902240
MKNK2 / Q9HBH9 / MAP kinase interacting serine/threonine kinase 2ENSG0000009987531
MKNK1 / Q9BUB5 / MAP kinase interacting serine/threonine kinase 1ENSG0000007927730


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR027442  MAP kinase activated protein kinase, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IEA
 biological_processGO:0000187 activation of MAPK activity TAS
 biological_processGO:0002224 toll-like receptor signaling pathway ISS
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007166 cell surface receptor signaling pathway IBA
 biological_processGO:0007265 Ras protein signal transduction TAS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IDA
 biological_processGO:0032496 response to lipopolysaccharide ISS
 biological_processGO:0034097 response to cytokine IDA
 biological_processGO:0044351 macropinocytosis ISS
 biological_processGO:0046777 protein autophosphorylation IBA
 biological_processGO:0048010 vascular endothelial growth factor receptor signaling pathway TAS
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity EXP
 molecular_functionGO:0004683 calmodulin-dependent protein kinase activity IBA
 molecular_functionGO:0004708 MAP kinase kinase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005516 calmodulin binding IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0009931 calcium-dependent protein serine/threonine kinase activity IBA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0051019 mitogen-activated protein kinase binding IBA


Pathways (from Reactome)
Pathway description
p38MAPK events
Oxidative Stress Induced Senescence
VEGFA-VEGFR2 Pathway
activated TAK1 mediates p38 MAPK activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000006 Autosomal dominant inheritance "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in heterozygotes. In the context of medical genetics, an autosomal dominant disorder is caused when a single copy of the mutant allele is present. Males and females are affected equally, and can both transmit the disorder with a risk of 50% for each child of inheriting the mutant allele." [HPO:curators]
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 HP:0000510 Retinitis pigmentosa "Hereditary degeneration and atrophy of the retina." [HPO:curators]
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 HP:0007663 Decreased central vision 
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000112062 MAPK14 / Q16539 / mitogen-activated protein kinase 14  / reaction / complex
 ENSG00000034152 MAP2K3 / P46734 / mitogen-activated protein kinase kinase 3  / reaction
 ENSG00000185386 MAPK11 / Q15759 / mitogen-activated protein kinase 11  / reaction / complex
 ENSG00000132475 H3F3B / P84243 / H3 histone family member 3B  / reaction
 ENSG00000276180 P62805 / HIST1H4I / histone cluster 1 H4 family member i  / reaction
 ENSG00000183598 Q71DI3 / HIST2H3D / histone cluster 2 H3 family member d  / reaction
 ENSG00000275714 P68431 / HIST1H3A / histone cluster 1 H3 family member a  / reaction
 ENSG00000108984 MAP2K6 / P52564 / mitogen-activated protein kinase kinase 6  / reaction






 

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