ENSG00000162889


Homo sapiens

Features
Gene ID: ENSG00000162889
  
Biological name :MAPKAPK2
  
Synonyms : MAPKAPK2 / mitogen-activated protein kinase-activated protein kinase 2 / P49137
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: q32.1
Gene start: 206684944
Gene end: 206734283
  
Corresponding Affymetrix probe sets: 201460_at (Human Genome U133 Plus 2.0 Array)   201461_s_at (Human Genome U133 Plus 2.0 Array)   215050_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000294981
Ensembl peptide - ENSP00000356070
NCBI entrez gene - 9261     See in Manteia.
OMIM - 602006
RefSeq - XM_017002810
RefSeq - NM_004759
RefSeq - NM_032960
RefSeq - XM_005273353
RefSeq Peptide - NP_004750
RefSeq Peptide - NP_116584
swissprot - P49137
Ensembl - ENSG00000162889
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mapkapk2aENSDARG00000002552Danio rerio
 mapkapk2bENSDARG00000018530Danio rerio
 MAPKAPK2ENSGALG00000000883Gallus gallus
 P49138ENSMUSG00000016528Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q16644 / MAPKAPK3 / mitogen-activated protein kinase-activated protein kinase 3ENSG0000011473865
Q8IW41 / MAPKAPK5 / mitogen-activated protein kinase-activated protein kinase 5ENSG0000008902240
MKNK2 / Q9HBH9 / MAP kinase interacting serine/threonine kinase 2ENSG0000009987529
MKNK1 / Q9BUB5 / MAP kinase interacting serine/threonine kinase 1ENSG0000007927729


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR027442  MAP kinase activated protein kinase, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade TAS
 biological_processGO:0000187 activation of MAPK activity TAS
 biological_processGO:0002224 toll-like receptor signaling pathway IEA
 biological_processGO:0006468 protein phosphorylation TAS
 biological_processGO:0006691 leukotriene metabolic process TAS
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IMP
 biological_processGO:0007265 Ras protein signal transduction TAS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IDA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0032675 regulation of interleukin-6 production IEA
 biological_processGO:0032680 regulation of tumor necrosis factor production IEA
 biological_processGO:0034097 response to cytokine IDA
 biological_processGO:0035924 cellular response to vascular endothelial growth factor stimulus IMP
 biological_processGO:0038066 p38MAPK cascade IEA
 biological_processGO:0042535 positive regulation of tumor necrosis factor biosynthetic process IEA
 biological_processGO:0043488 regulation of mRNA stability TAS
 biological_processGO:0044351 macropinocytosis IEA
 biological_processGO:0046777 protein autophosphorylation IBA
 biological_processGO:0048010 vascular endothelial growth factor receptor signaling pathway IMP
 biological_processGO:0048255 mRNA stabilization IEA
 biological_processGO:0048839 inner ear development IEA
 biological_processGO:0070935 3"-UTR-mediated mRNA stabilization IDA
 biological_processGO:1900034 regulation of cellular response to heat TAS
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity TAS
 molecular_functionGO:0004674 protein serine/threonine kinase activity EXP
 molecular_functionGO:0004683 calmodulin-dependent protein kinase activity IBA
 molecular_functionGO:0004871 obsolete signal transducer activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005516 calmodulin binding IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0009931 calcium-dependent protein serine/threonine kinase activity IBA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0051019 mitogen-activated protein kinase binding IBA


Pathways (from Reactome)
Pathway description
p38MAPK events
CREB phosphorylation
Synthesis of Leukotrienes (LT) and Eoxins (EX)
Oxidative Stress Induced Senescence
Regulation of HSF1-mediated heat shock response
VEGFA-VEGFR2 Pathway
activated TAK1 mediates p38 MAPK activation
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000112062 MAPK14 / Q16539 / mitogen-activated protein kinase 14  / complex / reaction
 ENSG00000185122 HSF1 / Q00613 / heat shock transcription factor 1  / reaction
 ENSG00000083312 TNPO1 / Q92973 / transportin 1  / reaction
 ENSG00000185650 Q07352 / ZFP36L1 / ZFP36 ring finger protein like 1  / reaction
 ENSG00000185386 MAPK11 / Q15759 / mitogen-activated protein kinase 11  / complex / reaction
 ENSG00000012779 ALOX5 / P09917 / arachidonate 5-lipoxygenase  / reaction
 ENSG00000118260 CREB1 / P16220 / cAMP responsive element binding protein 1  / reaction
 ENSG00000034152 MAP2K3 / P46734 / mitogen-activated protein kinase kinase 3  / reaction
 ENSG00000108984 MAP2K6 / P52564 / mitogen-activated protein kinase kinase 6  / reaction






 

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