ENSG00000012779


Homo sapiens

Features
Gene ID: ENSG00000012779
  
Biological name :ALOX5
  
Synonyms : ALOX5 / arachidonate 5-lipoxygenase / P09917
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: 1
Band: q11.21
Gene start: 45374176
Gene end: 45446119
  
Corresponding Affymetrix probe sets: 204445_s_at (Human Genome U133 Plus 2.0 Array)   204446_s_at (Human Genome U133 Plus 2.0 Array)   213952_s_at (Human Genome U133 Plus 2.0 Array)   214366_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000363512
Ensembl peptide - ENSP00000437634
Ensembl peptide - ENSP00000483803
NCBI entrez gene - 240     See in Manteia.
OMIM - 152390
RefSeq - NM_001320862
RefSeq - XM_017016012
RefSeq - NM_000698
RefSeq - NM_001256153
RefSeq - NM_001256154
RefSeq - NM_001320861
RefSeq Peptide - NP_000689
RefSeq Peptide - NP_001243082
RefSeq Peptide - NP_001243083
RefSeq Peptide - NP_001307790
RefSeq Peptide - NP_001307791
swissprot - P09917
swissprot - A0A087X109
Ensembl - ENSG00000012779
  
Related genetic diseases (OMIM): 152390 - {Atherosclerosis, susceptibility to}
  600807 - {Asthma, diminished response to antileukotriene treatment in}, 600807
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 alox5aENSDARG00000057273Danio rerio
 alox5b.1ENSDARG00000043085Danio rerio
 alox5b.2ENSDARG00000043089Danio rerio
 alox5b.3ENSDARG00000069966Danio rerio
 ENSGALG00000005857Gallus gallus
 Alox5ENSMUSG00000025701Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O15296 / ALOX15B / arachidonate 15-lipoxygenase, type BENSG0000017959342
ALOX12 / P18054 / arachidonate 12-lipoxygenase, 12S typeENSG0000010883941
O75342 / ALOX12B / arachidonate 12-lipoxygenase, 12R typeENSG0000017947741
ALOXE3 / Q9BYJ1 / arachidonate lipoxygenase 3ENSG0000017914841
ALOX15 / P16050 / arachidonate 15-lipoxygenaseENSG0000016190539


Protein motifs (from Interpro)
Interpro ID Name
 IPR000907  Lipoxygenase
 IPR001024  PLAT/LH2 domain
 IPR001885  Lipoxygenase, mammalian
 IPR013819  Lipoxygenase, C-terminal
 IPR020833  Lipoxygenase, iron binding site
 IPR020834  Lipoxygenase, conserved site
 IPR036226  Lipoxigenase, C-terminal domain superfamily
 IPR036392  PLAT/LH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002540 leukotriene production involved in inflammatory response IEA
 biological_processGO:0006691 leukotriene metabolic process TAS
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0019370 leukotriene biosynthetic process IEA
 biological_processGO:0019372 lipoxygenase pathway TAS
 biological_processGO:0035655 interleukin-18-mediated signaling pathway TAS
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:2001301 lipoxin biosynthetic process TAS
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space HDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005635 nuclear envelope TAS
 cellular_componentGO:0005641 nuclear envelope lumen IDA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016363 nuclear matrix IEA
 cellular_componentGO:0031965 nuclear membrane IEA
 cellular_componentGO:0034774 secretory granule lumen TAS
 cellular_componentGO:1904813 ficolin-1-rich granule lumen TAS
 molecular_functionGO:0004051 arachidonate 5-lipoxygenase activity TAS
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051213 dioxygenase activity IEA


Pathways (from Reactome)
Pathway description
Synthesis of 5-eicosatetraenoic acids
Synthesis of Leukotrienes (LT) and Eoxins (EX)
Synthesis of Lipoxins (LX)
Interleukin-4 and Interleukin-13 signaling
Neutrophil degranulation
Interleukin-18 signaling
Biosynthesis of D-series resolvins
Biosynthesis of maresins
Biosynthesis of E-series 18(S)-resolvins
Biosynthesis of aspirin-triggered D-series resolvins
Biosynthesis of E-series 18(R)-resolvins
Biosynthesis of DPAn-3-derived protectins and resolvins
Biosynthesis of DPAn-3-derived maresins
Biosynthesis of DPAn-3-derived 13-series resolvins
Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000162889 P49137 / MAPKAPK2 / mitogen-activated protein kinase-activated protein kinase 2  / reaction
 ENSG00000213316 LTC4S / Q16873 / leukotriene C4 synthase  / complex
 ENSG00000132965 P20292 / ALOX5AP / arachidonate 5-lipoxygenase activating protein  / complex






 

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