ENSDARG00000057273


Danio rerio

Features
Gene ID: ENSDARG00000057273
  
Biological name :alox5a
  
Synonyms : alox5a / arachidonate 5-lipoxygenase a
  
Possible biological names infered from orthology : ALOX5 / arachidonate 5-lipoxygenase / P09917 / P48999
  
Species: Danio rerio
  
Chr. number: 13
Strand: -1
Band:
Gene start: 18128275
Gene end: 18174864
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000074335
NCBI entrez gene - 567204     See in Manteia.
swissprot - B8A697
ZFIN ID - ZDB-GENE-090311-47
Ensembl - ENSDARG00000057273
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000005857Gallus gallus
 ALOX5ENSG00000012779Homo sapiens
 Alox5ENSMUSG00000025701Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
alox5b.2 / arachidonate 5-lipoxygenase b, tandem duplicate 2 / ALOX5* / P09917* / P48999* / arachidonate 5-lipoxygenase*ENSDARG0000004308964
alox5b.3 / arachidonate 5-lipoxygenase b, tandem duplicate 3 / ALOX5* / P09917* / P48999* / arachidonate 5-lipoxygenase*ENSDARG0000006996663
alox5b.1 / arachidonate 5-lipoxygenase b, tandem duplicate 1 / ALOX5* / P09917* / P48999* / arachidonate 5-lipoxygenase*ENSDARG0000004308560
alox12 / arachidonate 12-lipoxygenaseENSDARG0000006946344
si:dkey-17e16.9 / ALOX12* / P18054* / P39654* / P39655* / P55249* / ALOX15* / P16050* / Alox12e* / arachidonate 12-lipoxygenase* / arachidonate 15-lipoxygenase* / arachidonate lipoxygenase,...ENSDARG0000007378137
zgc:152891 / Alox8* / ALOXE3* / O15296* / O35936* / O70582* / O75342* / Q9BYJ1* / Q9WV07* / ALOX12B* / ALOX15B* / arachidonate lipoxygenase 3* / Arachidonate 8S-lipoxygenase * / arachidonat...ENSDARG0000001678936


Protein motifs (from Interpro)
Interpro ID Name
 IPR000907  Lipoxygenase
 IPR001024  PLAT/LH2 domain
 IPR001885  Lipoxygenase, mammalian
 IPR013819  Lipoxygenase, C-terminal
 IPR020833  Lipoxygenase, iron binding site
 IPR020834  Lipoxygenase, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0019369 arachidonic acid metabolic process IDA
 biological_processGO:0055114 oxidation-reduction process IEA
 molecular_functionGO:0004051 arachidonate 5-lipoxygenase activity IDA
 molecular_functionGO:0004464 leukotriene-C4 synthase activity IDA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0008391 arachidonic acid monooxygenase activity IDA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051213 dioxygenase activity IEA


Pathways (from Reactome)
Pathway description
Synthesis of 5-eicosatetraenoic acids
Synthesis of Leukotrienes (LT) and Eoxins (EX)
Synthesis of Lipoxins (LX)
Neutrophil degranulation
Biosynthesis of D-series resolvins
Biosynthesis of maresins
Biosynthesis of E-series 18(S)-resolvins
Biosynthesis of aspirin-triggered D-series resolvins
Biosynthesis of E-series 18(R)-resolvins
Biosynthesis of DPAn-3-derived protectins and resolvins
Biosynthesis of DPAn-3-derived maresins
Biosynthesis of DPAn-3-derived 13-series resolvins
Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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