ENSMUSG00000025701


Mus musculus

Features
Gene ID: ENSMUSG00000025701
  
Biological name :Alox5
  
Synonyms : Alox5 / Arachidonate 5-lipoxygenase / P48999
  
Possible biological names infered from orthology : P09917
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: E3
Gene start: 116410077
Gene end: 116461178
  
Corresponding Affymetrix probe sets: 10547153 (MoGene1.0st)   1441962_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000026795
Ensembl peptide - ENSMUSP00000145367
Ensembl peptide - ENSMUSP00000130780
Ensembl peptide - ENSMUSP00000130424
NCBI entrez gene - 11689     See in Manteia.
MGI - MGI:87999
RefSeq - NM_009662
RefSeq Peptide - NP_033792
swissprot - E9Q6H6
swissprot - A0A0N4SW45
swissprot - E9QA93
swissprot - P48999
Ensembl - ENSMUSG00000025701
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 alox5aENSDARG00000057273Danio rerio
 alox5b.1ENSDARG00000043085Danio rerio
 alox5b.2ENSDARG00000043089Danio rerio
 alox5b.3ENSDARG00000069966Danio rerio
 ENSGALG00000005857Gallus gallus
 ALOX5ENSG00000012779Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Alox8 / O35936 / Arachidonate 8S-lipoxygenase / O15296* / ALOX15B* / arachidonate 15-lipoxygenase, type B*ENSMUSG0000002089143
Aloxe3 / Q9WV07 / arachidonate lipoxygenase 3 / Q9BYJ1*ENSMUSG0000002089242
O70582 / Alox12b / Arachidonate 12-lipoxygenase, 12R-type / O75342*ENSMUSG0000003280741
Alox12 / P39655 / arachidonate 12-lipoxygenase / P18054* / arachidonate 12-lipoxygenase, 12S type*ENSMUSG0000000032040
Alox15 / P39654 / Arachidonate 15-lipoxygenase / P16050*ENSMUSG0000001892439
P55249 / Alox12e / arachidonate lipoxygenase, epidermalENSMUSG0000001890738


Protein motifs (from Interpro)
Interpro ID Name
 IPR000907  Lipoxygenase
 IPR001024  PLAT/LH2 domain
 IPR001885  Lipoxygenase, mammalian
 IPR013819  Lipoxygenase, C-terminal
 IPR020833  Lipoxygenase, iron binding site
 IPR020834  Lipoxygenase, conserved site
 IPR036226  Lipoxigenase, C-terminal domain superfamily
 IPR036392  PLAT/LH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002540 leukotriene production involved in inflammatory response IMP
 biological_processGO:0006691 leukotriene metabolic process IMP
 biological_processGO:0006954 inflammatory response IMP
 biological_processGO:0019370 leukotriene biosynthetic process IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005635 nuclear envelope IEA
 cellular_componentGO:0005641 nuclear envelope lumen IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016363 nuclear matrix ISO
 cellular_componentGO:0031965 nuclear membrane ISS
 molecular_functionGO:0004051 arachidonate 5-lipoxygenase activity ISO
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051213 dioxygenase activity IEA


Pathways (from Reactome)
Pathway description
Synthesis of 5-eicosatetraenoic acids
Synthesis of Leukotrienes (LT) and Eoxins (EX)
Synthesis of Lipoxins (LX)
Neutrophil degranulation
Biosynthesis of D-series resolvins
Biosynthesis of maresins
Biosynthesis of E-series 18(S)-resolvins
Biosynthesis of aspirin-triggered D-series resolvins
Biosynthesis of E-series 18(R)-resolvins
Biosynthesis of DPAn-3-derived protectins and resolvins
Biosynthesis of DPAn-3-derived maresins
Biosynthesis of DPAn-3-derived 13-series resolvins
Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000062 increased bone density "increased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
Show

Allelic Composition: Adora2atm1Jfc/Adora2atm1Jfc
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

 MP:0000692 small spleen "decreased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pax6tm2Pgr/Pax6tm2Pgr,Tg(Pdx1-cre)6Cvw/0
Genetic Background: involves: FVB * NMRI

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pax6tm2Pgr/Pax6tm2Pgr,Tg(Pdx1-cre)6Cvw/0
Genetic Background: involves: FVB * NMRI

 MP:0001845 abnormal inflammatory response "aberrant reaction of the microcirculation characterized by movement of fluid and leukocytes from the blood into extravascular tissues" [Pathology:ISBN 0-397-51047-0]
Show

Allelic Composition: Chd7Whi/Chd7+
Genetic Background: C3HeB/FeJ-Chd7Whi

 MP:0001876 decreased inflammatory response "less than expected response to injury, infection, or insult" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pax6tm2Pgr/Pax6tm2Pgr,Tg(Pdx1-cre)6Cvw/0
Genetic Background: involves: FVB * NMRI

 MP:0002463 abnormal neutrophil physiology "abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Chd7Whi/Chd7+
Genetic Background: C3HeB/FeJ-Chd7Whi

 MP:0004822 decreased susceptibility to experimental autoimmune uveoretinitis "reduced likelihood that an organism will develop disease symptoms similar to human sight-threatening inflammatory eye diseases upon induction by peripheral immunization with one of several uveitogenic retinal proteins (or with peptides derived from them), or by the adoptive transfer of lymphocytes specific to these antigens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adora2atm1Jfc/Adora2atm1Jfc
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

 MP:0005087 reduced acute inflammation "less than the expected early reaction of the microcirculation, characterized by movement of fluid and leukocytes from the blood into extravascular tissues; initiated by injury, infection, or local immune response " [Pathology:ISBN 0-397-51047-0, J:74478]
Show

Allelic Composition: Chd7Whi/Chd7+
Genetic Background: C3HeB/FeJ-Chd7Whi

 MP:0005145 increased circulating VLDL cholesterol level "greater than average concentration in the blood of very low density lipoprotein, which normally transports triglycerides from the intestine and liver to muscle and adipose tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Adora2atm1Jfc/Adora2atm1Jfc
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

 MP:0005597 decreased susceptibility to type I hypersensitivity reaction "less likelihood or resistance to developing a response manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized; it is IgE-mediated, and mast cell activation and degranulation are hallmarks" [Pathology:ISBN 0-397-51047-0, J:68588, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Chd7Whi/Chd7+
Genetic Background: C3HeB/FeJ-Chd7Whi

 MP:0005669 increased circulating leptin level "greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
Show

Allelic Composition: Adora2atm1Jfc/Adora2atm1Jfc
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

 MP:0008719 impaired neutrophil recruitment "reduced diffusion or accumulation of neutrophils in tissues or cells in response to a wide variety of substances released at the sites of inflammatory reactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Chd7Whi/Chd7+
Genetic Background: C3HeB/FeJ-Chd7Whi

 MP:0008720 impaired neutrophil migration "defect in the ability of neutrophils to move along a chemotactic gradient" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Chd7Whi/Chd7+
Genetic Background: C3HeB/FeJ-Chd7Whi

 MP:0008908 increased total fat pad weight "greater than average weight of the fat pads" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adora2atm1Jfc/Adora2atm1Jfc
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

 MP:0009814 increased prostaglandin level "increase in the amount in the body of any of a class of mediators with effects of vasodilation, vasoconstriction, and smooth muscle stimulation" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Chd7Whi/Chd7+
Genetic Background: C3HeB/FeJ-Chd7Whi

 MP:0009817 decreased leukotriene level "reduced concentration of a family of mediators derived from arachidonic acid which normally stimulate smooth muscle contraction, increase vascular permeability, and may be chemoattractants for inflammatory cells" [ISBN:0-397-51047-0 "Rubin E, et al. Pathology, 2nd edition"]
Show

Allelic Composition: Chd7Whi/Chd7+
Genetic Background: C3HeB/FeJ-Chd7Whi

 MP:0009818 abnormal thromboxane level 
Show

Allelic Composition: Chd7Whi/Chd7+
Genetic Background: C3HeB/FeJ-Chd7Whi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000016528 P49138 / Mapkapk2 / MAP kinase-activated protein kinase 2 / P49137* / mitogen-activated protein kinase-activated protein kinase 2*  / reaction
 ENSMUSG00000060063 P30355 / Alox5ap / Arachidonate 5-lipoxygenase-activating protein / P20292*  / complex
 ENSMUSG00000020377 Ltc4s / Q60860 / Leukotriene C4 synthase / Q16873*  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr