ENSMUSG00000020891


Mus musculus

Features
Gene ID: ENSMUSG00000020891
  
Biological name :Alox8
  
Synonyms : Alox8 / Arachidonate 8S-lipoxygenase / O35936
  
Possible biological names infered from orthology : ALOX15B / arachidonate 15-lipoxygenase, type B / O15296
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: B3
Gene start: 69183932
Gene end: 69197843
  
Corresponding Affymetrix probe sets: 10387257 (MoGene1.0st)   1425376_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000091621
Ensembl peptide - ENSMUSP00000021262
NCBI entrez gene - 11688     See in Manteia.
MGI - MGI:1098228
RefSeq - NM_009661
RefSeq Peptide - NP_033791
swissprot - B1ASX6
swissprot - O35936
Ensembl - ENSMUSG00000020891
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 zgc:152891ENSDARG00000016789Danio rerio
 O15296ENSG00000179593Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Aloxe3 / Q9WV07 / arachidonate lipoxygenase 3 / Q9BYJ1*ENSMUSG0000002089252
O70582 / Alox12b / Arachidonate 12-lipoxygenase, 12R-type / O75342*ENSMUSG0000003280749
Alox5 / P48999 / Arachidonate 5-lipoxygenase / P09917*ENSMUSG0000002570143
Alox12 / P39655 / arachidonate 12-lipoxygenase / P18054* / arachidonate 12-lipoxygenase, 12S type*ENSMUSG0000000032038
Alox15 / P39654 / Arachidonate 15-lipoxygenase / P16050*ENSMUSG0000001892437
P55249 / Alox12e / arachidonate lipoxygenase, epidermalENSMUSG0000001890736


Protein motifs (from Interpro)
Interpro ID Name
 IPR000907  Lipoxygenase
 IPR001024  PLAT/LH2 domain
 IPR001885  Lipoxygenase, mammalian
 IPR013819  Lipoxygenase, C-terminal
 IPR020833  Lipoxygenase, iron binding site
 IPR020834  Lipoxygenase, conserved site
 IPR036226  Lipoxigenase, C-terminal domain superfamily
 IPR036392  PLAT/LH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0010744 positive regulation of macrophage derived foam cell differentiation IEA
 biological_processGO:0019369 arachidonic acid metabolic process IEA
 biological_processGO:0019372 lipoxygenase pathway IDA
 biological_processGO:0035360 positive regulation of peroxisome proliferator activated receptor signaling pathway IMP
 biological_processGO:0043651 linoleic acid metabolic process IDA
 biological_processGO:0045618 positive regulation of keratinocyte differentiation IMP
 biological_processGO:0045786 negative regulation of cell cycle IEA
 biological_processGO:0045926 negative regulation of growth IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0090197 positive regulation of chemokine secretion IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol ISS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane ISO
 cellular_componentGO:0019898 extrinsic component of membrane IEA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0016165 linoleate 13S-lipoxygenase activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen IEA
 molecular_functionGO:0036403 arachidonate 8(S)-lipoxygenase activity IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0050473 arachidonate 15-lipoxygenase activity IEA
 molecular_functionGO:0051213 dioxygenase activity IEA


Pathways (from Reactome)
Pathway description
Synthesis of 15-eicosatetraenoic acid derivatives


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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