ENSMUSG00000032807


Mus musculus

Features
Gene ID: ENSMUSG00000032807
  
Biological name :Alox12b
  
Synonyms : Alox12b / Arachidonate 12-lipoxygenase, 12R-type / O70582
  
Possible biological names infered from orthology : O75342
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: B3
Gene start: 69156989
Gene end: 69169792
  
Corresponding Affymetrix probe sets: 10377490 (MoGene1.0st)   1418266_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000035250
NCBI entrez gene - 11686     See in Manteia.
MGI - MGI:1274782
RefSeq - NM_009659
RefSeq Peptide - NP_033789
swissprot - O70582
swissprot - Q2KHL0
Ensembl - ENSMUSG00000032807
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 zgc:152891ENSDARG00000016789Danio rerio
 O75342ENSG00000179477Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Aloxe3 / Q9WV07 / arachidonate lipoxygenase 3 / Q9BYJ1*ENSMUSG0000002089253
Alox8 / O35936 / Arachidonate 8S-lipoxygenase / O15296* / ALOX15B* / arachidonate 15-lipoxygenase, type B*ENSMUSG0000002089147
Alox5 / P48999 / Arachidonate 5-lipoxygenase / P09917*ENSMUSG0000002570139
Alox12 / P39655 / arachidonate 12-lipoxygenase / P18054* / arachidonate 12-lipoxygenase, 12S type*ENSMUSG0000000032035
P55249 / Alox12e / arachidonate lipoxygenase, epidermalENSMUSG0000001890733
Alox15 / P39654 / Arachidonate 15-lipoxygenase / P16050*ENSMUSG0000001892433


Protein motifs (from Interpro)
Interpro ID Name
 IPR000907  Lipoxygenase
 IPR001024  PLAT/LH2 domain
 IPR001885  Lipoxygenase, mammalian
 IPR013819  Lipoxygenase, C-terminal
 IPR020833  Lipoxygenase, iron binding site
 IPR020834  Lipoxygenase, conserved site
 IPR036226  Lipoxigenase, C-terminal domain superfamily
 IPR036392  PLAT/LH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006497 protein lipidation IMP
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006631 fatty acid metabolic process IEA
 biological_processGO:0006665 sphingolipid metabolic process ISO
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0019369 arachidonic acid metabolic process IEA
 biological_processGO:0019372 lipoxygenase pathway IEA
 biological_processGO:0043410 positive regulation of MAPK cascade IEA
 biological_processGO:0043651 linoleic acid metabolic process IDA
 biological_processGO:0046513 ceramide biosynthetic process IMP
 biological_processGO:0051122 hepoxilin biosynthetic process ISS
 biological_processGO:0055114 oxidation-reduction process ISO
 biological_processGO:0061436 establishment of skin barrier IMP
 biological_processGO:0070257 positive regulation of mucus secretion IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0003824 catalytic activity IDA
 molecular_functionGO:0004052 arachidonate 12-lipoxygenase activity IEA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ISO
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051213 dioxygenase activity IEA
 molecular_functionGO:1990136 linoleate 9S-lipoxygenase activity IDA


Pathways (from Reactome)
Pathway description
Synthesis of 12-eicosatetraenoic acid derivatives


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001190 reddish skin "skin has a more intense ruddy appearance than normal, often due to capillary congestion" [J:65038]
Show

Allelic Composition: Gad1tm1Tama/?,Lhx6tm2Vpa/Lhx6tm2Vpa
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * CBA

Allelic Composition: Alox12btm1.1Krie/Alox12btm1.1Krie
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * BALB/cJ * C57BL/6

 MP:0001191 abnormal skin condition "anomalous state of the skin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Alox12btm1.1Krie/Alox12btm1.1Krie
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * BALB/cJ * C57BL/6

 MP:0001192 scaly skin "skin covered with shedding scales or flakes" [J:65146]
Show

Allelic Composition: Gad1tm1Tama/?,Lhx6tm2Vpa/Lhx6tm2Vpa
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * CBA

 MP:0001196 shiny skin "skin with a glossy or glistening appearance" [J:56641]
Show

Allelic Composition: Gad1tm1Tama/?,Lhx6tm2Vpa/Lhx6tm2Vpa
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * CBA

Allelic Composition: Alox12btm1.1Krie/Alox12btm1.1Krie
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * BALB/cJ * C57BL/6

 MP:0001239 abnormal granular layer morphology "structural or developmental anomaly of the layer of flattened cells containing basophilic granules of keratohyalin and lying just above the stratum spinosum (spiny layer) of the epidermis" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Alox12btm1.1Krie/Alox12btm1.1Krie
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * BALB/cJ * C57BL/6

 MP:0001240 abnormal cornified layer morphology "structural or developmental anomaly of the outer layer of the epidermis, consisting of several layers of flat keratinized non-nucleated cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gad1tm1Tama/?,Lhx6tm2Vpa/Lhx6tm2Vpa
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * CBA

Allelic Composition: Alox12btm1.1Krie/Alox12btm1.1Krie
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * BALB/cJ * C57BL/6

 MP:0001429 dehydration "excessive water loss from the body or from an organ or bodily part" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:50053]
Show

Allelic Composition: Gad1tm1Tama/?,Lhx6tm2Vpa/Lhx6tm2Vpa
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * CBA

Allelic Composition: Alox12btm1.1Krie/Alox12btm1.1Krie
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * BALB/cJ * C57BL/6

 MP:0001547 abnormal lipid level "anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Pip5k1ctm2Csab/Pip5k1ctm2Csab
Genetic Background: Not Specified

 MP:0002796 impaired skin barrier function "impaired ability of the skin to regulate water loss; frequently leads to dehydration" [J:56641]
Show

Allelic Composition: Gad1tm1Tama/?,Lhx6tm2Vpa/Lhx6tm2Vpa
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * CBA

Allelic Composition: Alox12btm1.1Krie/Alox12btm1.1Krie
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * BALB/cJ * C57BL/6

 MP:0003853 dry skin "skin characterized by the lack of natural or normal moisture" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Gad1tm1Tama/?,Lhx6tm2Vpa/Lhx6tm2Vpa
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * CBA

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Gad1tm1Tama/?,Lhx6tm2Vpa/Lhx6tm2Vpa
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * CBA

Allelic Composition: Alox12btm1.1Krie/Alox12btm1.1Krie
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * BALB/cJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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