ENSMUSG00000020892


Mus musculus

Features
Gene ID: ENSMUSG00000020892
  
Biological name :Aloxe3
  
Synonyms : Aloxe3 / arachidonate lipoxygenase 3 / Q9WV07
  
Possible biological names infered from orthology : Q9BYJ1
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: B3
Gene start: 69125896
Gene end: 69149115
  
Corresponding Affymetrix probe sets: 10377473 (MoGene1.0st)   1449237_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000021268
Ensembl peptide - ENSMUSP00000134814
NCBI entrez gene - 23801     See in Manteia.
MGI - MGI:1345140
RefSeq - NM_011786
RefSeq - XM_006533257
RefSeq Peptide - NP_035916
swissprot - H3BJ21
swissprot - Q9WV07
Ensembl - ENSMUSG00000020892
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 zgc:152891ENSDARG00000016789Danio rerio
 ALOXE3ENSG00000179148Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O70582 / Alox12b / Arachidonate 12-lipoxygenase, 12R-type / O75342*ENSMUSG0000003280752
Alox8 / O35936 / Arachidonate 8S-lipoxygenase / O15296* / ALOX15B* / arachidonate 15-lipoxygenase, type B*ENSMUSG0000002089150
Alox5 / P48999 / Arachidonate 5-lipoxygenase / P09917*ENSMUSG0000002570140
Alox12 / P39655 / arachidonate 12-lipoxygenase / P18054* / arachidonate 12-lipoxygenase, 12S type*ENSMUSG0000000032036
Alox15 / P39654 / Arachidonate 15-lipoxygenase / P16050*ENSMUSG0000001892435
P55249 / Alox12e / arachidonate lipoxygenase, epidermalENSMUSG0000001890734


Protein motifs (from Interpro)
Interpro ID Name
 IPR000907  Lipoxygenase
 IPR001024  PLAT/LH2 domain
 IPR001885  Lipoxygenase, mammalian
 IPR013819  Lipoxygenase, C-terminal
 IPR020833  Lipoxygenase, iron binding site
 IPR020834  Lipoxygenase, conserved site
 IPR036226  Lipoxigenase, C-terminal domain superfamily
 IPR036392  PLAT/LH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006631 fatty acid metabolic process IEA
 biological_processGO:0006665 sphingolipid metabolic process ISO
 biological_processGO:0019233 sensory perception of pain IEA
 biological_processGO:0019369 arachidonic acid metabolic process IEA
 biological_processGO:0019372 lipoxygenase pathway IEA
 biological_processGO:0035357 peroxisome proliferator activated receptor signaling pathway IMP
 biological_processGO:0043651 linoleic acid metabolic process IEA
 biological_processGO:0045444 fat cell differentiation IMP
 biological_processGO:0046513 ceramide biosynthetic process IMP
 biological_processGO:0051122 hepoxilin biosynthetic process IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0061436 establishment of skin barrier IMP
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0003824 catalytic activity ISA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen IEA
 molecular_functionGO:0016829 lyase activity IEA
 molecular_functionGO:0016853 isomerase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051120 hepoxilin A3 synthase activity IDA
 molecular_functionGO:0051213 dioxygenase activity IEA


Pathways (from Reactome)
Pathway description
Synthesis of 12-eicosatetraenoic acid derivatives


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001240 abnormal cornified layer morphology "structural or developmental anomaly of the outer layer of the epidermis, consisting of several layers of flat keratinized non-nucleated cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Pip5k1ctm2Csab/Pip5k1ctm2Csab
Genetic Background: Not Specified

 MP:0001242 hyperkeratosis "increased depth of the corneal layer of the epidermis; thickening of the horny layer of the epidermis" [J:1133]
Show

Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Pip5k1ctm2Csab/Pip5k1ctm2Csab
Genetic Background: Not Specified

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
Show

Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Pip5k1ctm2Csab/Pip5k1ctm2Csab
Genetic Background: Not Specified

 MP:0001429 dehydration "excessive water loss from the body or from an organ or bodily part" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:50053]
Show

Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Pip5k1ctm2Csab/Pip5k1ctm2Csab
Genetic Background: Not Specified

 MP:0001547 abnormal lipid level "anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Pip5k1ctm2Csab/Pip5k1ctm2Csab
Genetic Background: Not Specified

 MP:0002796 impaired skin barrier function "impaired ability of the skin to regulate water loss; frequently leads to dehydration" [J:56641]
Show

Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Pip5k1ctm2Csab/Pip5k1ctm2Csab
Genetic Background: Not Specified

 MP:0009597 impaired stratum corneum desquamation "dysregulated shedding of the outermost layer of corneocytes, affecting the integrity and thickness of the stratum corneum; may result in xerotic and ichthyotic conditions" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Pip5k1ctm2Csab/Pip5k1ctm2Csab
Genetic Background: Not Specified

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Pip5k1ctm2Csab/Pip5k1ctm2Csab
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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