ENSMUSG00000018907


Mus musculus

Features
Gene ID: ENSMUSG00000018907
  
Biological name :Alox12e
  
Synonyms : Alox12e / arachidonate lipoxygenase, epidermal / P55249
  
Possible biological names infered from orthology :
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: B3
Gene start: 70315610
Gene end: 70322628
  
Corresponding Affymetrix probe sets: 10387838 (MoGene1.0st)   1426039_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000019051
NCBI entrez gene - 11685     See in Manteia.
MGI - MGI:1274790
RefSeq - XM_006532035
RefSeq - NM_145684
RefSeq - XM_006532034
RefSeq Peptide - NP_663717
swissprot - Q5F2E4
swissprot - P55249
Ensembl - ENSMUSG00000018907
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:dkey-17e16.9ENSDARG00000073781Danio rerio


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Alox12 / P39655 / arachidonate 12-lipoxygenase / P18054* / arachidonate 12-lipoxygenase, 12S type*ENSMUSG0000000032060
Alox15 / P39654 / Arachidonate 15-lipoxygenase / P16050*ENSMUSG0000001892460
Alox5 / P48999 / Arachidonate 5-lipoxygenase / P09917*ENSMUSG0000002570139
Aloxe3 / Q9WV07 / arachidonate lipoxygenase 3 / Q9BYJ1*ENSMUSG0000002089237
Alox8 / O35936 / Arachidonate 8S-lipoxygenase / O15296* / ALOX15B* / arachidonate 15-lipoxygenase, type B*ENSMUSG0000002089137
O70582 / Alox12b / Arachidonate 12-lipoxygenase, 12R-type / O75342*ENSMUSG0000003280735


Protein motifs (from Interpro)
Interpro ID Name
 IPR000907  Lipoxygenase
 IPR001024  PLAT/LH2 domain
 IPR001885  Lipoxygenase, mammalian
 IPR013819  Lipoxygenase, C-terminal
 IPR020833  Lipoxygenase, iron binding site
 IPR020834  Lipoxygenase, conserved site
 IPR036226  Lipoxigenase, C-terminal domain superfamily
 IPR036392  PLAT/LH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006631 fatty acid metabolic process IEA
 biological_processGO:0019369 arachidonic acid metabolic process IEA
 biological_processGO:0019372 lipoxygenase pathway IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0004052 arachidonate 12-lipoxygenase activity IEA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051213 dioxygenase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Adipor1tm1b(EUCOMM)Hmgu/Adipor1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Adipor1tm1b(EUCOMM)Hmgu/H

 MP:0005566 decreased blood urea nitrogen level "low circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Adipor1tm1b(EUCOMM)Hmgu/Adipor1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Adipor1tm1b(EUCOMM)Hmgu/H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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