ENSG00000179593


Homo sapiens

Features
Gene ID: ENSG00000179593
  
Biological name :ALOX15B
  
Synonyms : ALOX15B / arachidonate 15-lipoxygenase, type B / O15296
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: 1
Band: p13.1
Gene start: 8039017
Gene end: 8049134
  
Corresponding Affymetrix probe sets: 1555416_a_at (Human Genome U133 Plus 2.0 Array)   206714_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000369520
Ensembl peptide - ENSP00000369530
Ensembl peptide - ENSP00000458749
Ensembl peptide - ENSP00000460332
NCBI entrez gene - 247     See in Manteia.
OMIM - 603697
RefSeq - NM_001039130
RefSeq - NM_001039131
RefSeq - NM_001141
RefSeq Peptide - NP_001034219
RefSeq Peptide - NP_001034220
RefSeq Peptide - NP_001132
swissprot - O15296
swissprot - I3L1D5
Ensembl - ENSG00000179593
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 zgc:152891ENSDARG00000016789Danio rerio
 Alox8ENSMUSG00000020891Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ALOXE3 / Q9BYJ1 / arachidonate lipoxygenase 3ENSG0000017914854
O75342 / ALOX12B / arachidonate 12-lipoxygenase, 12R typeENSG0000017947751
ALOX5 / P09917 / arachidonate 5-lipoxygenaseENSG0000001277942
ALOX12 / P18054 / arachidonate 12-lipoxygenase, 12S typeENSG0000010883938
ALOX15 / P16050 / arachidonate 15-lipoxygenaseENSG0000016190538


Protein motifs (from Interpro)
Interpro ID Name
 IPR000907  Lipoxygenase
 IPR001024  PLAT/LH2 domain
 IPR001885  Lipoxygenase, mammalian
 IPR013819  Lipoxygenase, C-terminal
 IPR020833  Lipoxygenase, iron binding site
 IPR020834  Lipoxygenase, conserved site
 IPR036226  Lipoxigenase, C-terminal domain superfamily
 IPR036392  PLAT/LH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process TAS
 biological_processGO:0006915 apoptotic process TAS
 biological_processGO:0008285 negative regulation of cell proliferation IMP
 biological_processGO:0010744 positive regulation of macrophage derived foam cell differentiation IMP
 biological_processGO:0019369 arachidonic acid metabolic process IDA
 biological_processGO:0019372 lipoxygenase pathway TAS
 biological_processGO:0030336 negative regulation of cell migration TAS
 biological_processGO:0030850 prostate gland development NAS
 biological_processGO:0030856 regulation of epithelial cell differentiation NAS
 biological_processGO:0035360 positive regulation of peroxisome proliferator activated receptor signaling pathway IEA
 biological_processGO:0043651 linoleic acid metabolic process IEA
 biological_processGO:0045618 positive regulation of keratinocyte differentiation IEA
 biological_processGO:0045786 negative regulation of cell cycle IDA
 biological_processGO:0045926 negative regulation of growth IDA
 biological_processGO:0051122 hepoxilin biosynthetic process ISS
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0090197 positive regulation of chemokine secretion IMP
 cellular_componentGO:0005622 intracellular IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0019898 extrinsic component of membrane IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0005506 iron ion binding IDA
 molecular_functionGO:0005509 calcium ion binding IDA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0016165 linoleate 13S-lipoxygenase activity IDA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen IEA
 molecular_functionGO:0036403 arachidonate 8(S)-lipoxygenase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0050473 arachidonate 15-lipoxygenase activity TAS
 molecular_functionGO:0051213 dioxygenase activity IEA


Pathways (from Reactome)
Pathway description
Synthesis of 15-eicosatetraenoic acid derivatives


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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