ENSG00000161905


Homo sapiens

Features
Gene ID: ENSG00000161905
  
Biological name :ALOX15
  
Synonyms : ALOX15 / arachidonate 15-lipoxygenase / P16050
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: -1
Band: p13.2
Gene start: 4630902
Gene end: 4642294
  
Corresponding Affymetrix probe sets: 207328_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000460483
Ensembl peptide - ENSP00000293761
Ensembl peptide - ENSP00000458630
Ensembl peptide - ENSP00000458832
Ensembl peptide - ENSP00000460430
NCBI entrez gene - 246     See in Manteia.
OMIM - 152392
RefSeq - NM_001140
RefSeq Peptide - NP_001131
swissprot - I3L175
swissprot - P16050
Ensembl - ENSG00000161905
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:dkey-17e16.9ENSDARG00000073781Danio rerio
 Alox15ENSMUSG00000018924Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ALOX12 / P18054 / arachidonate 12-lipoxygenase, 12S typeENSG0000010883965
ALOX5 / P09917 / arachidonate 5-lipoxygenaseENSG0000001277940
O15296 / ALOX15B / arachidonate 15-lipoxygenase, type BENSG0000017959339
ALOXE3 / Q9BYJ1 / arachidonate lipoxygenase 3ENSG0000017914838
O75342 / ALOX12B / arachidonate 12-lipoxygenase, 12R typeENSG0000017947736


Protein motifs (from Interpro)
Interpro ID Name
 IPR000907  Lipoxygenase
 IPR001024  PLAT/LH2 domain
 IPR001885  Lipoxygenase, mammalian
 IPR013819  Lipoxygenase, C-terminal
 IPR020833  Lipoxygenase, iron binding site
 IPR020834  Lipoxygenase, conserved site
 IPR036226  Lipoxigenase, C-terminal domain superfamily
 IPR036392  PLAT/LH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001503 ossification ISS
 biological_processGO:0002820 negative regulation of adaptive immune response ISS
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006631 fatty acid metabolic process IEA
 biological_processGO:0006646 phosphatidylethanolamine biosynthetic process ISS
 biological_processGO:0006691 leukotriene metabolic process TAS
 biological_processGO:0006954 inflammatory response TAS
 biological_processGO:0010811 positive regulation of cell-substrate adhesion IDA
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0019369 arachidonic acid metabolic process NAS
 biological_processGO:0019372 lipoxygenase pathway IDA
 biological_processGO:0030282 bone mineralization ISS
 biological_processGO:0030838 positive regulation of actin filament polymerization ISS
 biological_processGO:0034116 positive regulation of heterotypic cell-cell adhesion IEA
 biological_processGO:0034976 response to endoplasmic reticulum stress ISS
 biological_processGO:0035358 regulation of peroxisome proliferator activated receptor signaling pathway ISS
 biological_processGO:0035963 cellular response to interleukin-13 IMP
 biological_processGO:0042060 wound healing ISS
 biological_processGO:0043277 apoptotic cell clearance ISS
 biological_processGO:0051122 hepoxilin biosynthetic process ISS
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IMP
 biological_processGO:0071277 cellular response to calcium ion IDA
 biological_processGO:1901074 regulation of engulfment of apoptotic cell ISS
 biological_processGO:2001303 lipoxin A4 biosynthetic process ISS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005811 lipid droplet IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane IDA
 molecular_functionGO:0004052 arachidonate 12-lipoxygenase activity TAS
 molecular_functionGO:0005506 iron ion binding ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005546 phosphatidylinositol-4,5-bisphosphate binding IDA
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0047977 hepoxilin-epoxide hydrolase activity IEA
 molecular_functionGO:0050473 arachidonate 15-lipoxygenase activity TAS
 molecular_functionGO:0051120 hepoxilin A3 synthase activity IEA
 molecular_functionGO:0051213 dioxygenase activity IEA
 molecular_functionGO:0097260 eoxin A4 synthase activity TAS


Pathways (from Reactome)
Pathway description
Synthesis of Leukotrienes (LT) and Eoxins (EX)
Synthesis of 12-eicosatetraenoic acid derivatives
Synthesis of 15-eicosatetraenoic acid derivatives
Interleukin-4 and Interleukin-13 signaling
Biosynthesis of DHA-derived SPMs
Biosynthesis of protectins
Biosynthesis of E-series 18(S)-resolvins
Biosynthesis of E-series 18(R)-resolvins
Biosynthesis of DPAn-6 SPMs
Biosynthesis of DPAn-3-derived protectins and resolvins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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