ENSG00000108839


Homo sapiens

Features
Gene ID: ENSG00000108839
  
Biological name :ALOX12
  
Synonyms : ALOX12 / arachidonate 12-lipoxygenase, 12S type / P18054
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: 1
Band: p13.1
Gene start: 6996065
Gene end: 7010736
  
Corresponding Affymetrix probe sets: 207206_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000251535
Ensembl peptide - ENSP00000467033
NCBI entrez gene - 239     See in Manteia.
OMIM - 152391
RefSeq - XM_011523780
RefSeq - NM_000697
RefSeq Peptide - NP_000688
swissprot - P18054
swissprot - K7ENN9
Ensembl - ENSG00000108839
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:dkey-17e16.9ENSDARG00000073781Danio rerio
 Alox12ENSMUSG00000000320Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ALOX15 / P16050 / arachidonate 15-lipoxygenaseENSG0000016190565
ALOX5 / P09917 / arachidonate 5-lipoxygenaseENSG0000001277942
O15296 / ALOX15B / arachidonate 15-lipoxygenase, type BENSG0000017959338
O75342 / ALOX12B / arachidonate 12-lipoxygenase, 12R typeENSG0000017947738
ALOXE3 / Q9BYJ1 / arachidonate lipoxygenase 3ENSG0000017914838


Protein motifs (from Interpro)
Interpro ID Name
 IPR000907  Lipoxygenase
 IPR001024  PLAT/LH2 domain
 IPR001885  Lipoxygenase, mammalian
 IPR013819  Lipoxygenase, C-terminal
 IPR020833  Lipoxygenase, iron binding site
 IPR020834  Lipoxygenase, conserved site
 IPR036226  Lipoxigenase, C-terminal domain superfamily
 IPR036392  PLAT/LH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006631 fatty acid metabolic process IEA
 biological_processGO:0010656 negative regulation of muscle cell apoptotic process IMP
 biological_processGO:0019369 arachidonic acid metabolic process IEA
 biological_processGO:0019372 lipoxygenase pathway IEA
 biological_processGO:0019395 fatty acid oxidation IMP
 biological_processGO:0042554 superoxide anion generation NAS
 biological_processGO:0043651 linoleic acid metabolic process IDA
 biological_processGO:0051121 hepoxilin metabolic process TAS
 biological_processGO:0051122 hepoxilin biosynthetic process ISS
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0061436 establishment of skin barrier IEA
 biological_processGO:0090331 negative regulation of platelet aggregation IEA
 biological_processGO:1901751 leukotriene A4 metabolic process IDA
 biological_processGO:2001301 lipoxin biosynthetic process TAS
 biological_processGO:2001303 lipoxin A4 biosynthetic process IDA
 biological_processGO:2001306 lipoxin B4 biosynthetic process IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0042383 sarcolemma IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0004052 arachidonate 12-lipoxygenase activity TAS
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016165 linoleate 13S-lipoxygenase activity IDA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0047977 hepoxilin-epoxide hydrolase activity ISS
 molecular_functionGO:0051120 hepoxilin A3 synthase activity TAS
 molecular_functionGO:0051213 dioxygenase activity IEA


Pathways (from Reactome)
Pathway description
Synthesis of Hepoxilins (HX) and Trioxilins (TrX)
Synthesis of Lipoxins (LX)
Synthesis of 12-eicosatetraenoic acid derivatives
Biosynthesis of DHA-derived SPMs
Biosynthesis of DPAn-6 SPMs
Biosynthesis of DPAn-3-derived maresins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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