ENSMUSG00000020377


Mus musculus

Features
Gene ID: ENSMUSG00000020377
  
Biological name :Ltc4s
  
Synonyms : Leukotriene C4 synthase / Ltc4s / Q60860
  
Possible biological names infered from orthology : Q16873
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: B1.3
Gene start: 50236461
Gene end: 50238616
  
Corresponding Affymetrix probe sets: 10385583 (MoGene1.0st)   1419692_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000098823
Ensembl peptide - ENSMUSP00000099833
Ensembl peptide - ENSMUSP00000121584
Ensembl peptide - ENSMUSP00000152524
NCBI entrez gene - 17001     See in Manteia.
MGI - MGI:107498
RefSeq - NM_001313968
RefSeq - NM_008521
RefSeq Peptide - NP_001300897
RefSeq Peptide - NP_032547
swissprot - Q8K355
swissprot - Q5SVR6
swissprot - Q60860
swissprot - A0A1Y7VLL2
Ensembl - ENSMUSG00000020377
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ltc4sENSDARG00000062598Danio rerio
 LTC4SENSGALG00000021275Gallus gallus
 LTC4SENSG00000213316Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mgst2 / microsomal glutathione S-transferase 2 / Q99735*ENSMUSG0000007460439
P30355 / Alox5ap / Arachidonate 5-lipoxygenase-activating protein / P20292*ENSMUSG0000006006327


Protein motifs (from Interpro)
Interpro ID Name
 IPR001129  Membrane-associated, eicosanoid/glutathione metabolism (MAPEG) protein
 IPR001446  5-lipoxygenase-activating protein
 IPR018295  FLAP/GST2/LTC4S, conserved site
 IPR023352  Membrane associated eicosanoid/glutathione metabolism-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006691 leukotriene metabolic process ISO
 biological_processGO:0019370 leukotriene biosynthetic process IEA
 biological_processGO:0043085 positive regulation of catalytic activity IEA
 biological_processGO:0098869 cellular oxidant detoxification IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005635 nuclear envelope IEA
 cellular_componentGO:0005640 nuclear outer membrane IEA
 cellular_componentGO:0005783 endoplasmic reticulum IBA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004364 glutathione transferase activity IBA
 molecular_functionGO:0004464 leukotriene-C4 synthase activity IEA
 molecular_functionGO:0004602 glutathione peroxidase activity IBA
 molecular_functionGO:0008047 enzyme activator activity IEA
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0016829 lyase activity IEA
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
Synthesis of 5-eicosatetraenoic acids
Synthesis of Leukotrienes (LT) and Eoxins (EX)
Synthesis of Lipoxins (LX)
Biosynthesis of maresin conjugates in tissue regeneration (MCTR)
Biosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001844 autoimmune response "condition in which cells and/or antibodies arise from and are directed against one s own tissues " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Slc6a3tm2(tTA)Xz/Slc6a3+,Tg(tetO-COX8A/PstI*)1Ctm/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6J * SJL

 MP:0002148 immune system: hypersensitivity "immune response that results in tissue injury" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Itgb4tm1Fgg/Itgb4tm1Fgg
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002405 respiratory system inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the respiratory system" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Sp5tm1Rbe/Sp5tm1Rbe,T/T+
Genetic Background: involves: 129P2/Ola * C57BL/6J

 MP:0002531 type I hypersensitivity reaction "a reaction manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized; it is IgE-mediated, and mast cell activation and degranulation are hallmarks" [Pathology , 2nd edition:ISBN 0-397-51047-0]
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Allelic Composition: Itgb4tm1Fgg/Itgb4tm1Fgg
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0003071 decreased vascular permeability "reduced or slower ability of the blood vessels to permit the passage of substances such as fluid, heat, or gases" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Sp5tm1Rbe/Sp5tm1Rbe,T/T+
Genetic Background: involves: 129P2/Ola * C57BL/6J

 MP:0005501 abnormal skin physiology "atypical function of the membranous protective covering of the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Slc6a3tm2(tTA)Xz/Slc6a3+,Tg(tetO-COX8A/PstI*)1Ctm/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6J * SJL

 MP:0005597 decreased susceptibility to type I hypersensitivity reaction "less likelihood or resistance to developing a response manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized; it is IgE-mediated, and mast cell activation and degranulation are hallmarks" [Pathology:ISBN 0-397-51047-0, J:68588, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pla2g5tm1Jarm/Pla2g5tm1Jarm
Genetic Background: B6.129-Pla2g5tm1Jarm

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000025701 Alox5 / P48999 / Arachidonate 5-lipoxygenase / P09917*  / complex
 ENSMUSG00000060063 P30355 / Alox5ap / Arachidonate 5-lipoxygenase-activating protein / P20292*  / complex
 ENSMUSG00000020377 Ltc4s / Q60860 / Leukotriene C4 synthase / Q16873*  / complex






 

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