ENSMUSG00000074604


Mus musculus

Features
Gene ID: ENSMUSG00000074604
  
Biological name :Mgst2
  
Synonyms : Mgst2 / microsomal glutathione S-transferase 2
  
Possible biological names infered from orthology : Q99735
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: C
Gene start: 51660360
Gene end: 51682677
  
Corresponding Affymetrix probe sets: 10491952 (MoGene1.0st)   1452592_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000096705
Ensembl peptide - ENSMUSP00000141745
Ensembl peptide - ENSMUSP00000125670
NCBI entrez gene - 211666     See in Manteia.
MGI - MGI:2448481
RefSeq - XM_011240057
RefSeq - NM_001310482
RefSeq - NM_174995
RefSeq - XM_006501248
RefSeq Peptide - NP_001297411
RefSeq Peptide - NP_778160
swissprot - E0CZ62
swissprot - A2RST1
swissprot - A0A0A6YWX7
Ensembl - ENSMUSG00000074604
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mgst2ENSDARG00000071345Danio rerio
 MGST2ENSGALG00000009803Gallus gallus
 MGST2ENSG00000085871Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ltc4s / Q60860 / Leukotriene C4 synthase / Q16873*ENSMUSG0000002037740
P30355 / Alox5ap / Arachidonate 5-lipoxygenase-activating protein / P20292*ENSMUSG0000006006328


Protein motifs (from Interpro)
Interpro ID Name
 IPR001129  Membrane-associated, eicosanoid/glutathione metabolism (MAPEG) protein
 IPR001446  5-lipoxygenase-activating protein
 IPR023352  Membrane associated eicosanoid/glutathione metabolism-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process ISO
 biological_processGO:0006691 leukotriene metabolic process IEA
 biological_processGO:0006750 glutathione biosynthetic process ISO
 biological_processGO:0019370 leukotriene biosynthetic process ISO
 biological_processGO:0043085 positive regulation of catalytic activity IEA
 biological_processGO:0046466 membrane lipid catabolic process ISO
 biological_processGO:0098869 cellular oxidant detoxification IEA
 cellular_componentGO:0005635 nuclear envelope IBA
 cellular_componentGO:0005783 endoplasmic reticulum IBA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane ISO
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle ISO
 molecular_functionGO:0004364 glutathione transferase activity ISO
 molecular_functionGO:0004464 leukotriene-C4 synthase activity ISO
 molecular_functionGO:0004602 glutathione peroxidase activity ISO
 molecular_functionGO:0008047 enzyme activator activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
Glutathione conjugation
Aflatoxin activation and detoxification


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ssu2tm1.1Xmx/Ssu2tm1.1Xmx
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0009767 decreased sensitivity to xenobiotic induced morbidity/mortality "increase in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ssu2tm1.1Xmx/Ssu2tm1.1Xmx
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0013502 decreased fibroblast apoptosis "reduction in the timing or the number of fibroblast cells undergoing programmed cell death" [MGI:csmith]
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Allelic Composition: Ssu2tm1.1Xmx/Ssu2tm1.1Xmx
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0020353 abnormal endoplasmic reticulum stress "any anomaly in the accumulation of misfolded or unfolded proteins in the endoplasmic reticulum lumen; this accumulation maybe stimulated by genetic or enviromental factors" [ORCID: orcid.org/0000-0003-4606-0597, PMID:21266244]
Show

Allelic Composition: Ssu2tm1.1Xmx/Ssu2tm1.1Xmx
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000074604 Mgst2 / microsomal glutathione S-transferase 2 / Q99735*  / complex






 

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