ENSG00000085871


Homo sapiens

Features
Gene ID: ENSG00000085871
  
Biological name :MGST2
  
Synonyms : MGST2 / microsomal glutathione S-transferase 2 / Q99735
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: 1
Band: q31.1
Gene start: 139665768
Gene end: 139740745
  
Corresponding Affymetrix probe sets: 204168_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000265498
Ensembl peptide - ENSP00000423008
Ensembl peptide - ENSP00000424278
Ensembl peptide - ENSP00000482639
NCBI entrez gene - 4258     See in Manteia.
OMIM - 601733
RefSeq - XM_017008213
RefSeq - NM_001204366
RefSeq - NM_001204367
RefSeq - NM_001204368
RefSeq - NM_002413
RefSeq - XM_006714221
RefSeq - XM_017008211
RefSeq - XM_017008212
RefSeq Peptide - NP_001191295
RefSeq Peptide - NP_001191296
RefSeq Peptide - NP_001191297
RefSeq Peptide - NP_002404
swissprot - Q99735
Ensembl - ENSG00000085871
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mgst2ENSDARG00000071345Danio rerio
 MGST2ENSGALG00000009803Gallus gallus
 Mgst2ENSMUSG00000074604Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
LTC4S / Q16873 / leukotriene C4 synthaseENSG0000021331644
P20292 / ALOX5AP / arachidonate 5-lipoxygenase activating proteinENSG0000013296529


Protein motifs (from Interpro)
Interpro ID Name
 IPR001129  Membrane-associated, eicosanoid/glutathione metabolism (MAPEG) protein
 IPR001446  5-lipoxygenase-activating protein
 IPR018295  FLAP/GST2/LTC4S, conserved site
 IPR023352  Membrane associated eicosanoid/glutathione metabolism-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IDA
 biological_processGO:0006691 leukotriene metabolic process IEA
 biological_processGO:0006750 glutathione biosynthetic process IDA
 biological_processGO:0006805 xenobiotic metabolic process TAS
 biological_processGO:0010243 response to organonitrogen compound IEA
 biological_processGO:0019370 leukotriene biosynthetic process IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0043085 positive regulation of catalytic activity IEA
 biological_processGO:0046466 membrane lipid catabolic process IDA
 biological_processGO:0050729 positive regulation of inflammatory response NAS
 biological_processGO:0098869 cellular oxidant detoxification IEA
 biological_processGO:1901687 glutathione derivative biosynthetic process TAS
 cellular_componentGO:0005635 nuclear envelope IBA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IBA
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031090 organelle membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0004364 glutathione transferase activity TAS
 molecular_functionGO:0004464 leukotriene-C4 synthase activity IEA
 molecular_functionGO:0004602 glutathione peroxidase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008047 enzyme activator activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
Glutathione conjugation
Aflatoxin activation and detoxification


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000085871 MGST2 / Q99735 / microsomal glutathione S-transferase 2  / complex






 

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