ENSG00000132965


Homo sapiens

Features
Gene ID: ENSG00000132965
  
Biological name :ALOX5AP
  
Synonyms : ALOX5AP / arachidonate 5-lipoxygenase activating protein / P20292
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 13
Strand: 1
Band: q12.3
Gene start: 30713478
Gene end: 30764426
  
Corresponding Affymetrix probe sets: 204174_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000479870
Ensembl peptide - ENSP00000369858
NCBI entrez gene - 241     See in Manteia.
OMIM - 603700
RefSeq - NM_001204406
RefSeq - NM_001629
RefSeq Peptide - NP_001191335
RefSeq Peptide - NP_001620
swissprot - P20292
swissprot - A0A087WW23
Ensembl - ENSG00000132965
  
Related genetic diseases (OMIM): 601367 - {Stroke, susceptibility to}, 601367
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 alox5apENSDARG00000054755Danio rerio
 ALOX5APENSGALG00000026781Gallus gallus
 P30355ENSMUSG00000060063Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MGST2 / Q99735 / microsomal glutathione S-transferase 2ENSG0000008587120
LTC4S / Q16873 / leukotriene C4 synthaseENSG0000021331618


Protein motifs (from Interpro)
Interpro ID Name
 IPR001129  Membrane-associated, eicosanoid/glutathione metabolism (MAPEG) protein
 IPR001446  5-lipoxygenase-activating protein
 IPR018295  FLAP/GST2/LTC4S, conserved site
 IPR023352  Membrane associated eicosanoid/glutathione metabolism-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002540 leukotriene production involved in inflammatory response IEA
 biological_processGO:0002675 positive regulation of acute inflammatory response IEA
 biological_processGO:0006691 leukotriene metabolic process IEA
 biological_processGO:0019370 leukotriene biosynthetic process IEA
 biological_processGO:0019372 lipoxygenase pathway IEA
 biological_processGO:0043085 positive regulation of catalytic activity IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0070207 protein homotrimerization IEA
 biological_processGO:0071277 cellular response to calcium ion IDA
 biological_processGO:2001301 lipoxin biosynthetic process TAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005635 nuclear envelope IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031965 nuclear membrane IEA
 molecular_functionGO:0004051 arachidonate 5-lipoxygenase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008047 enzyme activator activity IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0047485 protein N-terminus binding IPI
 molecular_functionGO:0050544 arachidonic acid binding IDA


Pathways (from Reactome)
Pathway description
Synthesis of 5-eicosatetraenoic acids
Synthesis of Leukotrienes (LT) and Eoxins (EX)
Synthesis of Lipoxins (LX)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000213316 LTC4S / Q16873 / leukotriene C4 synthase  / complex
 ENSG00000012779 ALOX5 / P09917 / arachidonate 5-lipoxygenase  / complex
 ENSG00000132965 P20292 / ALOX5AP / arachidonate 5-lipoxygenase activating protein  / complex






 

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