ENSMUSG00000060063


Mus musculus

Features
Gene ID: ENSMUSG00000060063
  
Biological name :Alox5ap
  
Synonyms : Alox5ap / Arachidonate 5-lipoxygenase-activating protein / P30355
  
Possible biological names infered from orthology : P20292
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: G3
Gene start: 149264767
Gene end: 149288153
  
Corresponding Affymetrix probe sets: 10527638 (MoGene1.0st)   1452016_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000144115
Ensembl peptide - ENSMUSP00000144472
Ensembl peptide - ENSMUSP00000071130
NCBI entrez gene - 11690     See in Manteia.
MGI - MGI:107505
RefSeq - NM_009663
RefSeq - NM_001308462
RefSeq Peptide - NP_001295391
RefSeq Peptide - NP_033793
swissprot - P30355
swissprot - A0A0J9YV38
swissprot - A0A0J9YUC8
Ensembl - ENSMUSG00000060063
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 alox5apENSDARG00000054755Danio rerio
 ALOX5APENSGALG00000026781Gallus gallus
 P20292ENSG00000132965Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mgst2 / microsomal glutathione S-transferase 2 / Q99735*ENSMUSG0000007460425
Ltc4s / Q60860 / Leukotriene C4 synthase / Q16873*ENSMUSG0000002037725


Protein motifs (from Interpro)
Interpro ID Name
 IPR001129  Membrane-associated, eicosanoid/glutathione metabolism (MAPEG) protein
 IPR001446  5-lipoxygenase-activating protein
 IPR018295  FLAP/GST2/LTC4S, conserved site
 IPR023352  Membrane associated eicosanoid/glutathione metabolism-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002540 leukotriene production involved in inflammatory response IMP
 biological_processGO:0002675 positive regulation of acute inflammatory response IEA
 biological_processGO:0006691 leukotriene metabolic process IEA
 biological_processGO:0019370 leukotriene biosynthetic process IEA
 biological_processGO:0019372 lipoxygenase pathway IEA
 biological_processGO:0043085 positive regulation of catalytic activity IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0070207 protein homotrimerization IEA
 biological_processGO:0071277 cellular response to calcium ion ISO
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005635 nuclear envelope IEA
 cellular_componentGO:0005783 endoplasmic reticulum IBA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031965 nuclear membrane ISS
 molecular_functionGO:0004051 arachidonate 5-lipoxygenase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008047 enzyme activator activity IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0047485 protein N-terminus binding ISO
 molecular_functionGO:0050544 arachidonic acid binding ISS


Pathways (from Reactome)
Pathway description
Synthesis of 5-eicosatetraenoic acids
Synthesis of Leukotrienes (LT) and Eoxins (EX)
Synthesis of Lipoxins (LX)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001876 decreased inflammatory response "less than expected response to injury, infection, or insult" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pafah1b1tm1Awb/Pafah1b1+
Genetic Background: involves: 129S6/SvEvTac

 MP:0003436 resistance to induced arthritis "less likely to be striken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:75303]
Show

Allelic Composition: Pafah1b1tm1Awb/Pafah1b1+
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Alox5aptm1Jdm/Alox5ap+
Genetic Background: DBA/1LacJ-Alox5aptm1Jdm

 MP:0005087 reduced acute inflammation "less than the expected early reaction of the microcirculation, characterized by movement of fluid and leukocytes from the blood into extravascular tissues; initiated by injury, infection, or local immune response " [Pathology:ISBN 0-397-51047-0, J:74478]
Show

Allelic Composition: Chd7Whi/Chd7+
Genetic Background: C3HeB/FeJ-Chd7Whi

 MP:0005597 decreased susceptibility to type I hypersensitivity reaction "less likelihood or resistance to developing a response manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized; it is IgE-mediated, and mast cell activation and degranulation are hallmarks" [Pathology:ISBN 0-397-51047-0, J:68588, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Chd7Whi/Chd7+
Genetic Background: C3HeB/FeJ-Chd7Whi

 MP:0008719 impaired neutrophil recruitment "reduced diffusion or accumulation of neutrophils in tissues or cells in response to a wide variety of substances released at the sites of inflammatory reactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Chd7Whi/Chd7+
Genetic Background: C3HeB/FeJ-Chd7Whi

 MP:0009811 abnormal prostaglandin level "anomaly in the amount in the body of any of a class of mediators with effects of vasodilation, vasoconstriction, and smooth muscle stimulation" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Pafah1b1tm1Awb/Pafah1b1+
Genetic Background: involves: 129S6/SvEvTac

 MP:0009813 abnormal leukotriene level "abnormal concentration of a family of mediators derived from arachidonic acid which normally stimulate smooth muscle contraction, increase vascular permeability, and may be chemoattractants for inflammatory cells" [ISBN:0-397-51047-0 "Rubin E, et al. Pathology, 2nd edition"]
Show

Allelic Composition: Pafah1b1tm1Awb/Pafah1b1+
Genetic Background: involves: 129S6/SvEvTac

 MP:0009814 increased prostaglandin level "increase in the amount in the body of any of a class of mediators with effects of vasodilation, vasoconstriction, and smooth muscle stimulation" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Chd7Whi/Chd7+
Genetic Background: C3HeB/FeJ-Chd7Whi

 MP:0009817 decreased leukotriene level "reduced concentration of a family of mediators derived from arachidonic acid which normally stimulate smooth muscle contraction, increase vascular permeability, and may be chemoattractants for inflammatory cells" [ISBN:0-397-51047-0 "Rubin E, et al. Pathology, 2nd edition"]
Show

Allelic Composition: Chd7Whi/Chd7+
Genetic Background: C3HeB/FeJ-Chd7Whi

Allelic Composition: Alox5aptm1Jdm/Alox5ap+
Genetic Background: DBA/1LacJ-Alox5aptm1Jdm

 MP:0009818 abnormal thromboxane level 
Show

Allelic Composition: Chd7Whi/Chd7+
Genetic Background: C3HeB/FeJ-Chd7Whi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000025701 Alox5 / P48999 / Arachidonate 5-lipoxygenase / P09917*  / complex
 ENSMUSG00000060063 P30355 / Alox5ap / Arachidonate 5-lipoxygenase-activating protein / P20292*  / complex
 ENSMUSG00000020377 Ltc4s / Q60860 / Leukotriene C4 synthase / Q16873*  / complex






 

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