ENSG00000185650


Homo sapiens

Features
Gene ID: ENSG00000185650
  
Biological name :ZFP36L1
  
Synonyms : Q07352 / ZFP36L1 / ZFP36 ring finger protein like 1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 14
Strand: -1
Band: q24.1
Gene start: 68787660
Gene end: 68796253
  
Corresponding Affymetrix probe sets: 211962_s_at (Human Genome U133 Plus 2.0 Array)   211965_at (Human Genome U133 Plus 2.0 Array)   213277_at (Human Genome U133 Plus 2.0 Array)   213284_at (Human Genome U133 Plus 2.0 Array)   229054_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000451093
Ensembl peptide - ENSP00000450784
Ensembl peptide - ENSP00000452119
Ensembl peptide - ENSP00000450600
Ensembl peptide - ENSP00000388402
Ensembl peptide - ENSP00000337386
NCBI entrez gene - 677     See in Manteia.
OMIM - 601064
RefSeq - NM_001244698
RefSeq - NM_004926
RefSeq - NM_001244701
RefSeq Peptide - NP_001231630
RefSeq Peptide - NP_001231627
RefSeq Peptide - NP_004917
swissprot - Q07352
swissprot - A0A024R658
swissprot - G3V2D5
swissprot - G3V2P5
swissprot - G3V382
swissprot - G3V515
Ensembl - ENSG00000185650
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 zfp36l1aENSDARG00000016154Danio rerio
 zfp36l1bENSDARG00000021443Danio rerio
 ZFP36L1ENSGALG00000039228Gallus gallus
 P23950ENSMUSG00000021127Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P47974 / ZFP36L2 / ZFP36 ring finger protein like 2ENSG0000015251856
ZFP36 / ZFP36 ring finger proteinENSG0000012801633


Protein motifs (from Interpro)
Interpro ID Name
 IPR000571  Zinc finger, CCCH-type
 IPR007635  Tis11B-like protein, N-terminal
 IPR036855  Zinc finger, CCCH-type superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IDA
 biological_processGO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IEA
 biological_processGO:0001570 vasculogenesis IEA
 biological_processGO:0003342 proepicardium development IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0006402 mRNA catabolic process IEA
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007507 heart development IEA
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0009611 response to wounding IDA
 biological_processGO:0010468 regulation of gene expression IDA
 biological_processGO:0010837 regulation of keratinocyte proliferation IMP
 biological_processGO:0014065 phosphatidylinositol 3-kinase signaling IDA
 biological_processGO:0021915 neural tube development IEA
 biological_processGO:0031086 nuclear-transcribed mRNA catabolic process, deadenylation-independent decay ISS
 biological_processGO:0031440 regulation of mRNA 3"-end processing IDA
 biological_processGO:0032869 cellular response to insulin stimulus IDA
 biological_processGO:0033077 T cell differentiation in thymus ISS
 biological_processGO:0035264 multicellular organism growth IEA
 biological_processGO:0038066 p38MAPK cascade ISS
 biological_processGO:0043488 regulation of mRNA stability IMP
 biological_processGO:0043491 protein kinase B signaling ISS
 biological_processGO:0044344 cellular response to fibroblast growth factor stimulus ISS
 biological_processGO:0045577 regulation of B cell differentiation ISS
 biological_processGO:0045600 positive regulation of fat cell differentiation ISS
 biological_processGO:0045616 regulation of keratinocyte differentiation IMP
 biological_processGO:0045647 negative regulation of erythrocyte differentiation IDA
 biological_processGO:0045657 positive regulation of monocyte differentiation IDA
 biological_processGO:0045661 regulation of myoblast differentiation ISS
 biological_processGO:0048382 mesendoderm development ISS
 biological_processGO:0048568 embryonic organ development IEA
 biological_processGO:0051028 mRNA transport IMP
 biological_processGO:0060710 chorio-allantoic fusion IEA
 biological_processGO:0060712 spongiotrophoblast layer development IEA
 biological_processGO:0061158 3"-UTR-mediated mRNA destabilization IMP
 biological_processGO:0070371 ERK1 and ERK2 cascade IDA
 biological_processGO:0071320 cellular response to cAMP IDA
 biological_processGO:0071356 cellular response to tumor necrosis factor IDA
 biological_processGO:0071364 cellular response to epidermal growth factor stimulus IDA
 biological_processGO:0071375 cellular response to peptide hormone stimulus IDA
 biological_processGO:0071385 cellular response to glucocorticoid stimulus IDA
 biological_processGO:0071456 cellular response to hypoxia IMP
 biological_processGO:0071472 cellular response to salt stress ISS
 biological_processGO:0071560 cellular response to transforming growth factor beta stimulus IDA
 biological_processGO:0072091 regulation of stem cell proliferation ISS
 biological_processGO:0097403 cellular response to raffinose ISS
 biological_processGO:1900153 positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay ISS
 biological_processGO:1901991 negative regulation of mitotic cell cycle phase transition ISS
 biological_processGO:1902172 regulation of keratinocyte apoptotic process IMP
 biological_processGO:1904582 positive regulation of intracellular mRNA localization IMP
 cellular_componentGO:0000932 P-body IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IBA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISM
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity NAS
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003729 mRNA binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017091 AU-rich element binding IEA
 molecular_functionGO:0035925 mRNA 3"-UTR AU-rich region binding IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0071889 14-3-3 protein binding IDA


Pathways (from Reactome)
Pathway description
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000162889 P49137 / MAPKAPK2 / mitogen-activated protein kinase-activated protein kinase 2  / reaction
 ENSG00000142208 AKT1 / P31749 / AKT serine/threonine kinase 1  / reaction
 ENSG00000166913 YWHAB / P31946 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta  / reaction / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr