ENSMUSG00000021127


Mus musculus

Features
Gene ID: ENSMUSG00000021127
  
Biological name :Zfp36l1
  
Synonyms : P23950 / Zfp36l1 / zinc finger protein 36, C3H type-like 1
  
Possible biological names infered from orthology : Q07352 / ZFP36 ring finger protein like 1
  
Species: Mus musculus
  
Chr. number: 12
Strand: -1
Band: C3
Gene start: 80107754
Gene end: 80113013
  
Corresponding Affymetrix probe sets: 10401238 (MoGene1.0st)   1422528_a_at (Mouse Genome 430 2.0 Array)   1450644_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000127522
Ensembl peptide - ENSMUSP00000151682
Ensembl peptide - ENSMUSP00000151269
Ensembl peptide - ENSMUSP00000021552
NCBI entrez gene - 12192     See in Manteia.
MGI - MGI:107946
RefSeq - NM_007564
RefSeq Peptide - NP_031590
swissprot - A0A1W2P6I1
swissprot - A0A1W2P7G3
swissprot - P23950
swissprot - Q543H2
Ensembl - ENSMUSG00000021127
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 zfp36l1aENSDARG00000016154Danio rerio
 zfp36l1bENSDARG00000021443Danio rerio
 ZFP36L1ENSGALG00000039228Gallus gallus
 Q07352ENSG00000185650Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P23949 / Zfp36l2 / zinc finger protein 36, C3H type-like 2 / P47974* / ZFP36 ring finger protein like 2*ENSMUSG0000004581756
Zfp36 / P22893 / zinc finger protein 36 / ZFP36 ring finger protein*ENSMUSG0000004478632
Q5ISE2 / Zfp36l3 / zinc finger protein 36, C3H type-like 3ENSMUSG0000005933431


Protein motifs (from Interpro)
Interpro ID Name
 IPR000571  Zinc finger, CCCH-type
 IPR007635  Tis11B-like protein, N-terminal
 IPR036855  Zinc finger, CCCH-type superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade ISS
 biological_processGO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IDA
 biological_processGO:0001570 vasculogenesis IMP
 biological_processGO:0003342 proepicardium development IMP
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0006402 mRNA catabolic process ISO
 biological_processGO:0006417 regulation of translation IMP
 biological_processGO:0006915 apoptotic process IMP
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007507 heart development IMP
 biological_processGO:0008283 cell proliferation IMP
 biological_processGO:0009611 response to wounding ISO
 biological_processGO:0010468 regulation of gene expression ISS
 biological_processGO:0010837 regulation of keratinocyte proliferation ISO
 biological_processGO:0014065 phosphatidylinositol 3-kinase signaling ISO
 biological_processGO:0021915 neural tube development IMP
 biological_processGO:0031086 nuclear-transcribed mRNA catabolic process, deadenylation-independent decay ISS
 biological_processGO:0031440 regulation of mRNA 3"-end processing ISO
 biological_processGO:0032869 cellular response to insulin stimulus ISO
 biological_processGO:0033077 T cell differentiation in thymus IGI
 biological_processGO:0035264 multicellular organism growth IMP
 biological_processGO:0038066 p38MAPK cascade IDA
 biological_processGO:0043488 regulation of mRNA stability ISS
 biological_processGO:0043491 protein kinase B signaling IMP
 biological_processGO:0044344 cellular response to fibroblast growth factor stimulus IDA
 biological_processGO:0045577 regulation of B cell differentiation IMP
 biological_processGO:0045600 positive regulation of fat cell differentiation IDA
 biological_processGO:0045616 regulation of keratinocyte differentiation ISO
 biological_processGO:0045647 negative regulation of erythrocyte differentiation ISS
 biological_processGO:0045657 positive regulation of monocyte differentiation ISS
 biological_processGO:0045661 regulation of myoblast differentiation IMP
 biological_processGO:0048382 mesendoderm development IDA
 biological_processGO:0048568 embryonic organ development IMP
 biological_processGO:0051028 mRNA transport ISO
 biological_processGO:0060710 chorio-allantoic fusion IMP
 biological_processGO:0060712 spongiotrophoblast layer development IMP
 biological_processGO:0061158 3"-UTR-mediated mRNA destabilization ISO
 biological_processGO:0070371 ERK1 and ERK2 cascade ISS
 biological_processGO:0071320 cellular response to cAMP IDA
 biological_processGO:0071356 cellular response to tumor necrosis factor ISS
 biological_processGO:0071364 cellular response to epidermal growth factor stimulus ISS
 biological_processGO:0071375 cellular response to peptide hormone stimulus ISO
 biological_processGO:0071385 cellular response to glucocorticoid stimulus ISS
 biological_processGO:0071456 cellular response to hypoxia ISS
 biological_processGO:0071472 cellular response to salt stress IDA
 biological_processGO:0071560 cellular response to transforming growth factor beta stimulus ISS
 biological_processGO:0072091 regulation of stem cell proliferation IDA
 biological_processGO:0097403 cellular response to raffinose IDA
 biological_processGO:1900153 positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay ISS
 biological_processGO:1901991 negative regulation of mitotic cell cycle phase transition IMP
 biological_processGO:1902172 regulation of keratinocyte apoptotic process ISO
 biological_processGO:1904582 positive regulation of intracellular mRNA localization ISO
 biological_processGO:1904628 cellular response to phorbol 13-acetate 12-myristate ISO
 cellular_componentGO:0000932 P-body ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IBA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003729 mRNA binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017091 AU-rich element binding IEA
 molecular_functionGO:0035925 mRNA 3"-UTR AU-rich region binding ISS
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0071889 14-3-3 protein binding ISS


Pathways (from Reactome)
Pathway description
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000260 abnormal angiogenesis "aberrant process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Tg(CD4,HLA-DQA1,HLA-DQB1)N8Ell/Tg(CD4,HLA-DQA1,HLA-DQB1)N8Ell
Genetic Background: NOD.Cg-H2-Ab1tm1Gru Tg(CD4,HLA-DQA1,HLA-DQB1)N8Ell

 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0000295 poorly developed ventricular trabeculae "retarded differentation of the supporting bundles of muscular fibers lining the walls of the ventricles of the heart" [J:29971]
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Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Tg(CD4,HLA-DQA1,HLA-DQB1)N8Ell/Tg(CD4,HLA-DQA1,HLA-DQB1)N8Ell
Genetic Background: NOD.Cg-H2-Ab1tm1Gru Tg(CD4,HLA-DQA1,HLA-DQB1)N8Ell

 MP:0000351 increased cell proliferation "greater than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Prkcbtilc/Prkcbtilc
Genetic Background: C57BL/6JSfdAnu-Prkcbtilc/Apb

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Prkcbtilc/Prkcbtilc
Genetic Background: C57BL/6JSfdAnu-Prkcbtilc/Apb

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Prkcbtilc/Prkcbtilc
Genetic Background: C57BL/6JSfdAnu-Prkcbtilc/Apb

 MP:0000704 abnormal thymus development "anomaly in the formation and/or differentiation of the thymus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Prkcbtilc/Prkcbtilc
Genetic Background: C57BL/6JSfdAnu-Prkcbtilc/Apb

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Tg(CD4,HLA-DQA1,HLA-DQB1)N8Ell/Tg(CD4,HLA-DQA1,HLA-DQB1)N8Ell
Genetic Background: NOD.Cg-H2-Ab1tm1Gru Tg(CD4,HLA-DQA1,HLA-DQB1)N8Ell

 MP:0001648 abnormal apoptosis "excessive or absent cell death in a particular tissue or cell type" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:25248]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0001711 abnormal placenta 
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Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Tg(CD4,HLA-DQA1,HLA-DQB1)N8Ell/Tg(CD4,HLA-DQA1,HLA-DQB1)N8Ell
Genetic Background: NOD.Cg-H2-Ab1tm1Gru Tg(CD4,HLA-DQA1,HLA-DQB1)N8Ell

 MP:0001715 placental labyrinth hypoplasia "reduction in cell number of the placental labyrinth, the structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:61790]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0002024 T cell derived lymphoma "group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Prkcbtilc/Prkcbtilc
Genetic Background: C57BL/6JSfdAnu-Prkcbtilc/Apb

 MP:0002026 leukemia "progressive proliferation of abnormal leukocytes in hematopoietic tissues, organs and blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18542]
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Allelic Composition: Prkcbtilc/Prkcbtilc
Genetic Background: C57BL/6JSfdAnu-Prkcbtilc/Apb

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Prkcbtilc/Prkcbtilc
Genetic Background: C57BL/6JSfdAnu-Prkcbtilc/Apb

 MP:0003057 abnormal epicardium morphology "anomalous structure of the visceral layer of the pericardium that surrounds and attaches to all the surfaces of the heart" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0003229 abnormal vitelline vasculature "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]
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Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Tg(CD4,HLA-DQA1,HLA-DQB1)N8Ell/Tg(CD4,HLA-DQA1,HLA-DQB1)N8Ell
Genetic Background: NOD.Cg-H2-Ab1tm1Gru Tg(CD4,HLA-DQA1,HLA-DQB1)N8Ell

 MP:0003231 abnormal placental vasculature "malformation in the vessels of the placenta" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93157]
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Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Tg(CD4,HLA-DQA1,HLA-DQB1)N8Ell/Tg(CD4,HLA-DQA1,HLA-DQB1)N8Ell
Genetic Background: NOD.Cg-H2-Ab1tm1Gru Tg(CD4,HLA-DQA1,HLA-DQB1)N8Ell

 MP:0003403 absent placental labyrinth "malformed structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:73417]
Show

Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Tg(CD4,HLA-DQA1,HLA-DQB1)N8Ell/Tg(CD4,HLA-DQA1,HLA-DQB1)N8Ell
Genetic Background: NOD.Cg-H2-Ab1tm1Gru Tg(CD4,HLA-DQA1,HLA-DQB1)N8Ell

 MP:0003644 thymus atrophy "wasting of the thymus resulting in reduced size " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Prkcbtilc/Prkcbtilc
Genetic Background: C57BL/6JSfdAnu-Prkcbtilc/Apb

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Tg(CD4,HLA-DQA1,HLA-DQB1)N8Ell/Tg(CD4,HLA-DQA1,HLA-DQB1)N8Ell
Genetic Background: NOD.Cg-H2-Ab1tm1Gru Tg(CD4,HLA-DQA1,HLA-DQB1)N8Ell

 MP:0004229 abnormal embryonic erythropoiesis "anomaly in the development of primarily large, nucleated erythroblasts occurring in blood islands in the yolk sac, generally occurs from E7-E11 in the mouse and through 10 weeks in humans" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Tg(CD4,HLA-DQA1,HLA-DQB1)N8Ell/Tg(CD4,HLA-DQA1,HLA-DQB1)N8Ell
Genetic Background: NOD.Cg-H2-Ab1tm1Gru Tg(CD4,HLA-DQA1,HLA-DQB1)N8Ell

 MP:0004255 abnormal spongiotrophoblast layer morphology "anomaly in the structure of the outer structural layer of the rodent placenta" [PMID:11433360]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0004787 abnormal dorsal aorta morphology "any structural anomaly of the paired arterial structures of the embryo that supplies each developing somite via efferent segmental arteries; the dorsal aortae articulate with the umbilical arteries, which return mixed blood to the villi of the chorion for reoxygenation" [ISBN:0-914294-08-3 "Gray s Anatomy"]
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Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Tg(CD4,HLA-DQA1,HLA-DQB1)N8Ell/Tg(CD4,HLA-DQA1,HLA-DQB1)N8Ell
Genetic Background: NOD.Cg-H2-Ab1tm1Gru Tg(CD4,HLA-DQA1,HLA-DQB1)N8Ell

 MP:0005031 abnormal trophoblast "malformation of the mesectodermal cell layer covering the blastocyst that erodes the uterine mucosa and contributes to the formation of the placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Tg(CD4,HLA-DQA1,HLA-DQB1)N8Ell/Tg(CD4,HLA-DQA1,HLA-DQB1)N8Ell
Genetic Background: NOD.Cg-H2-Ab1tm1Gru Tg(CD4,HLA-DQA1,HLA-DQB1)N8Ell

 MP:0009657 failure of chorioallantoic fusion "failure to initiate and/or complete the formation of a highly vascularized extra-embryonic fetal membrane by fusion of the chorion and allantois" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Zfp36l1tm1Seb/Zfp36l1tm1Seb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Zfp36l1tm1Seb/Zfp36l1tm1Seb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0011204 abnormal visceral yolk sac blood island morphology "any structural anomaly of the masses of developing blood cells attached to endothelium in the yolk sac" [PMID:16140152]
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Allelic Composition: Zfp36l1tm1Seb/Zfp36l1tm1Seb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0012253 abnormal intersomitic vessel morphology "any structural anomaly of the primary blood vessel sprouts that originate from the dorsal aorta and posterior cardinal vein and align dorsoventrally at the myotomal boundaries between somites" [MGI:anna]
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Allelic Composition: Zfp36l1tm1Seb/Zfp36l1tm1Seb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000001729 Akt1 / P31750 / Mus musculus thymoma viral proto-onco 1 (Akt1), transcript variant 3, mRNA. / P31749* / AKT serine/threonine kinase 1*  / reaction
 ENSMUSG00000016528 P49138 / Mapkapk2 / MAP kinase-activated protein kinase 2 / P49137* / mitogen-activated protein kinase-activated protein kinase 2*  / reaction
 ENSMUSG00000018326 Ywhab / Q9CQV8 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide / P31946* / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta*  / reaction / complex






 

1 s.

 
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