ENSMUSG00000045817


Mus musculus

Features
Gene ID: ENSMUSG00000045817
  
Biological name :Zfp36l2
  
Synonyms : P23949 / Zfp36l2 / zinc finger protein 36, C3H type-like 2
  
Possible biological names infered from orthology : P47974 / ZFP36 ring finger protein like 2
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: E4
Gene start: 84183931
Gene end: 84187947
  
Corresponding Affymetrix probe sets: 10453272 (MoGene1.0st)   1437626_at (Mouse Genome 430 2.0 Array)   1439054_at (Mouse Genome 430 2.0 Array)   1451034_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000050820
NCBI entrez gene - 12193     See in Manteia.
MGI - MGI:107945
RefSeq - NM_001001806
RefSeq Peptide - NP_001001806
swissprot - P23949
Ensembl - ENSMUSG00000045817
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 zfp36l2ENSDARG00000021806Danio rerio
 ZFP36L2ENSGALG00000033129Gallus gallus
 P47974ENSG00000152518Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P23950 / Zfp36l1 / zinc finger protein 36, C3H type-like 1 / Q07352* / ZFP36 ring finger protein like 1*ENSMUSG0000002112739
Q5ISE2 / Zfp36l3 / zinc finger protein 36, C3H type-like 3ENSMUSG0000005933428
Zfp36 / P22893 / zinc finger protein 36 / ZFP36 ring finger protein*ENSMUSG0000004478623


Protein motifs (from Interpro)
Interpro ID Name
 IPR000571  Zinc finger, CCCH-type
 IPR007635  Tis11B-like protein, N-terminal
 IPR036855  Zinc finger, CCCH-type superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IDA
 biological_processGO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IDA
 biological_processGO:0006402 mRNA catabolic process IDA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0009611 response to wounding IEA
 biological_processGO:0030097 hemopoiesis IMP
 biological_processGO:0033077 T cell differentiation in thymus IGI
 biological_processGO:0035019 somatic stem cell population maintenance IMP
 biological_processGO:0043488 regulation of mRNA stability IEA
 biological_processGO:0044344 cellular response to fibroblast growth factor stimulus IEA
 biological_processGO:0045577 regulation of B cell differentiation IMP
 biological_processGO:0045599 negative regulation of fat cell differentiation IDA
 biological_processGO:0048103 somatic stem cell division IMP
 biological_processGO:0060216 definitive hemopoiesis IMP
 biological_processGO:0061158 3"-UTR-mediated mRNA destabilization IEA
 biological_processGO:0070371 ERK1 and ERK2 cascade IEA
 biological_processGO:0071356 cellular response to tumor necrosis factor IEA
 biological_processGO:0071364 cellular response to epidermal growth factor stimulus IEA
 biological_processGO:0071385 cellular response to glucocorticoid stimulus IEA
 biological_processGO:0071560 cellular response to transforming growth factor beta stimulus IEA
 biological_processGO:0097011 cellular response to granulocyte macrophage colony-stimulating factor stimulus IEA
 biological_processGO:1900153 positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IDA
 biological_processGO:1901991 negative regulation of mitotic cell cycle phase transition IMP
 biological_processGO:1904628 cellular response to phorbol 13-acetate 12-myristate ISO
 biological_processGO:2000737 negative regulation of stem cell differentiation IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IBA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0017091 AU-rich element binding IEA
 molecular_functionGO:0035925 mRNA 3"-UTR AU-rich region binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Nfil3tm1.1Brad/Nfil3+
Genetic Background: B6.Cg-Nfil3tm1.1Brad

 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Nfil3tm1.1Brad/Nfil3+
Genetic Background: B6.Cg-Nfil3tm1.1Brad

 MP:0000222 decreased neutrophil count "fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nfil3tm1.1Brad/Nfil3+
Genetic Background: B6.Cg-Nfil3tm1.1Brad

 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Nfil3tm1.1Brad/Nfil3+
Genetic Background: B6.Cg-Nfil3tm1.1Brad

 MP:0000333 decreased bone marrow cell number "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Nfil3tm1.1Brad/Nfil3+
Genetic Background: B6.Cg-Nfil3tm1.1Brad

 MP:0000351 increased cell proliferation "greater than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Prkcbtilc/Prkcbtilc
Genetic Background: C57BL/6JSfdAnu-Prkcbtilc/Apb

 MP:0000465 gastrointestinal hemorrhage "bleeding in the stomach and/or the intestines" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Nfil3tm1.1Brad/Nfil3+
Genetic Background: B6.Cg-Nfil3tm1.1Brad

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
Show

Allelic Composition: Nfil3tm1.1Brad/Nfil3+
Genetic Background: B6.Cg-Nfil3tm1.1Brad

 MP:0000603 pale liver "liver lacking normal coloration, often refers to bloodless condition" [J:18048]
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Allelic Composition: Nfil3tm1.1Brad/Nfil3+
Genetic Background: B6.Cg-Nfil3tm1.1Brad

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Prkcbtilc/Prkcbtilc
Genetic Background: C57BL/6JSfdAnu-Prkcbtilc/Apb

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Prkcbtilc/Prkcbtilc
Genetic Background: C57BL/6JSfdAnu-Prkcbtilc/Apb

 MP:0000704 abnormal thymus development "anomaly in the formation and/or differentiation of the thymus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Prkcbtilc/Prkcbtilc
Genetic Background: C57BL/6JSfdAnu-Prkcbtilc/Apb

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Nfil3tm1.1Brad/Nfil3+
Genetic Background: B6.Cg-Nfil3tm1.1Brad

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Nfil3tm1.1Brad/Nfil3+
Genetic Background: B6.Cg-Nfil3tm1.1Brad

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Nfil3tm1.1Brad/Nfil3+
Genetic Background: B6.Cg-Nfil3tm1.1Brad

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Hexbtm1Rlp/Hexb+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002024 T cell derived lymphoma "group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Prkcbtilc/Prkcbtilc
Genetic Background: C57BL/6JSfdAnu-Prkcbtilc/Apb

 MP:0002026 leukemia "progressive proliferation of abnormal leukocytes in hematopoietic tissues, organs and blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18542]
Show

Allelic Composition: Prkcbtilc/Prkcbtilc
Genetic Background: C57BL/6JSfdAnu-Prkcbtilc/Apb

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Prkcbtilc/Prkcbtilc
Genetic Background: C57BL/6JSfdAnu-Prkcbtilc/Apb

 MP:0002123 abnormal hematopoiesis "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nfil3tm1.1Brad/Nfil3+
Genetic Background: B6.Cg-Nfil3tm1.1Brad

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nfil3tm1.1Brad/Nfil3+
Genetic Background: B6.Cg-Nfil3tm1.1Brad

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nfil3tm1.1Brad/Nfil3+
Genetic Background: B6.Cg-Nfil3tm1.1Brad

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
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Allelic Composition: Nfil3tm1.1Brad/Nfil3+
Genetic Background: B6.Cg-Nfil3tm1.1Brad

 MP:0003396 abnormal embryonic hematopoiesis "anomaly in the development of primarily large, nucleated erythroblasts as well as some megakaryocytes and primitive macrophages occuring in blood islands in the yolk sac, generally occurs from E7-E11 in the mouse and through 10 weeks in humans " [J:94136, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Nfil3tm1.1Brad/Nfil3+
Genetic Background: B6.Cg-Nfil3tm1.1Brad

 MP:0003644 thymus atrophy "wasting of the thymus resulting in reduced size " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Prkcbtilc/Prkcbtilc
Genetic Background: C57BL/6JSfdAnu-Prkcbtilc/Apb

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Nfil3tm1.1Brad/Nfil3+
Genetic Background: B6.Cg-Nfil3tm1.1Brad

 MP:0004969 pale kidney "kidney lacks normal reddish coloration; often occurs with a bloodless or reduced vasculature condition" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nfil3tm1.1Brad/Nfil3+
Genetic Background: B6.Cg-Nfil3tm1.1Brad

 MP:0005152 pancytopenia "reduction in the number of erythrocytes, all types of white blood cells, and platelets in the circulating blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:20450]
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Allelic Composition: Nfil3tm1.1Brad/Nfil3+
Genetic Background: B6.Cg-Nfil3tm1.1Brad

 MP:0009278 abnormal bone marrow cell physiology "any functional anomaly of any of the cells found in the blood" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Nfil3tm1.1Brad/Nfil3+
Genetic Background: B6.Cg-Nfil3tm1.1Brad

 MP:0009339 decreased splenocyte number "reduction in the expected number of cells of the spleen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nfil3tm1.1Brad/Nfil3+
Genetic Background: B6.Cg-Nfil3tm1.1Brad

 MP:0009395 persistence of primitive erythrocytes "presence of increased numbers of nucleated red blood cells at stages when these cells are normally replaced by mature, enucleated, red blood cells" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Nfil3tm1.1Brad/Nfil3+
Genetic Background: B6.Cg-Nfil3tm1.1Brad

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Nfil3tm1.1Brad/Nfil3+
Genetic Background: B6.Cg-Nfil3tm1.1Brad

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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