ENSMUSG00000044786


Mus musculus

Features
Gene ID: ENSMUSG00000044786
  
Biological name :Zfp36
  
Synonyms : P22893 / Zfp36 / zinc finger protein 36
  
Possible biological names infered from orthology : ZFP36 ring finger protein
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: B1
Gene start: 28376784
Gene end: 28380253
  
Corresponding Affymetrix probe sets: 10561453 (MoGene1.0st)   1452519_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000057815
Ensembl peptide - ENSMUSP00000146830
NCBI entrez gene - 22695     See in Manteia.
MGI - MGI:99180
RefSeq - NM_011756
RefSeq Peptide - NP_035886
swissprot - P22893
swissprot - Q3U3D2
swissprot - Q9DBE5
Ensembl - ENSMUSG00000044786
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 zgc:162730ENSDARG00000103720Danio rerio
 ZFP36ENSG00000128016Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P23950 / Zfp36l1 / zinc finger protein 36, C3H type-like 1 / Q07352* / ZFP36 ring finger protein like 1*ENSMUSG0000002112734
P23949 / Zfp36l2 / zinc finger protein 36, C3H type-like 2 / P47974* / ZFP36 ring finger protein like 2*ENSMUSG0000004581734
Q5ISE2 / Zfp36l3 / zinc finger protein 36, C3H type-like 3ENSMUSG0000005933431


Protein motifs (from Interpro)
Interpro ID Name
 IPR000571  Zinc finger, CCCH-type
 IPR036855  Zinc finger, CCCH-type superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0000165 MAPK cascade IMP
 biological_processGO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay ISO
 biological_processGO:0000289 nuclear-transcribed mRNA poly(A) tail shortening ISO
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IGI
 biological_processGO:0006402 mRNA catabolic process ISS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0009611 response to wounding ISO
 biological_processGO:0010837 regulation of keratinocyte proliferation ISO
 biological_processGO:0031086 nuclear-transcribed mRNA catabolic process, deadenylation-independent decay ISO
 biological_processGO:0032680 regulation of tumor necrosis factor production ISS
 biological_processGO:0032897 negative regulation of viral transcription ISO
 biological_processGO:0035278 miRNA mediated inhibition of translation IDA
 biological_processGO:0035556 intracellular signal transduction IDA
 biological_processGO:0038066 p38MAPK cascade IDA
 biological_processGO:0042594 response to starvation ISO
 biological_processGO:0043488 regulation of mRNA stability IMP
 biological_processGO:0044344 cellular response to fibroblast growth factor stimulus ISO
 biological_processGO:0045085 negative regulation of interleukin-2 biosynthetic process IMP
 biological_processGO:0045600 positive regulation of fat cell differentiation IDA
 biological_processGO:0045616 regulation of keratinocyte differentiation ISO
 biological_processGO:0045638 negative regulation of myeloid cell differentiation IMP
 biological_processGO:0045647 negative regulation of erythrocyte differentiation ISS
 biological_processGO:0050728 negative regulation of inflammatory response IMP
 biological_processGO:0050779 RNA destabilization IMP
 biological_processGO:0051028 mRNA transport ISO
 biological_processGO:0060213 positive regulation of nuclear-transcribed mRNA poly(A) tail shortening ISO
 biological_processGO:0061014 positive regulation of mRNA catabolic process IMP
 biological_processGO:0061158 3"-UTR-mediated mRNA destabilization ISO
 biological_processGO:0070935 3"-UTR-mediated mRNA stabilization ISS
 biological_processGO:0071222 cellular response to lipopolysaccharide ISS
 biological_processGO:0071356 cellular response to tumor necrosis factor ISS
 biological_processGO:0071364 cellular response to epidermal growth factor stimulus ISS
 biological_processGO:0071385 cellular response to glucocorticoid stimulus ISS
 biological_processGO:0097011 cellular response to granulocyte macrophage colony-stimulating factor stimulus ISS
 biological_processGO:1900153 positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IDA
 biological_processGO:1901835 positive regulation of deadenylation-independent decapping of nuclear-transcribed mRNA ISO
 biological_processGO:1902172 regulation of keratinocyte apoptotic process ISO
 biological_processGO:1904246 negative regulation of polynucleotide adenylyltransferase activity IMP
 biological_processGO:1904582 positive regulation of intracellular mRNA localization ISO
 biological_processGO:2000637 positive regulation of gene silencing by miRNA ISO
 cellular_componentGO:0000932 P-body ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0010494 cytoplasmic stress granule ISS
 cellular_componentGO:0030014 CCR4-NOT complex IDA
 cellular_componentGO:0070578 RISC-loading complex ISO
 cellular_componentGO:0098745 Dcp1-Dcp2 complex ISO
 cellular_componentGO:1990904 ribonucleoprotein complex IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003729 mRNA binding ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017091 AU-rich element binding ISO
 molecular_functionGO:0019899 enzyme binding ISO
 molecular_functionGO:0019901 protein kinase binding ISO
 molecular_functionGO:0019957 C-C chemokine binding ISO
 molecular_functionGO:0031072 heat shock protein binding ISO
 molecular_functionGO:0035925 mRNA 3"-UTR AU-rich region binding ISO
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070063 RNA polymerase binding IDA
 molecular_functionGO:0071889 14-3-3 protein binding ISS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Nsd3tm1b(EUCOMM)Hmgu/Nsd3tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Nsd3tm1b(EUCOMM)Hmgu/H

 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gpx1tm1Ysh/Gpx1tm1Ysh
Genetic Background: B6.129-Gpx1tm1Ysh

 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tia1tm1Andp/Tia1tm1Andp,Zfp36tm1Pjb/Zfp36tm1Pjb
Genetic Background: B6.Cg-Tia1tm1Andp Zfp36tm1Pjb

Allelic Composition: Zfp36tm1Pjb/Zfp36tm1Pjb
Genetic Background: B6.Cg-Zfp36tm1Pjb

 MP:0000220 increased monocyte count "greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Zfp36tm1Pjb/Zfp36tm1Pjb
Genetic Background: B6.Cg-Zfp36tm1Pjb

 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gpx1tm1Ysh/Gpx1tm1Ysh
Genetic Background: B6.129-Gpx1tm1Ysh

 MP:0000322 increased granulocyte number "greater than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tia1tm1Andp/Tia1tm1Andp
Genetic Background: B6.Cg-Tia1tm1Andp

 MP:0000414 alopecia "absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796]
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Allelic Composition: Gpx1tm1Ysh/Gpx1tm1Ysh
Genetic Background: B6.129-Gpx1tm1Ysh

 MP:0000496 abnormal small intestine morphology "structural or developmental anomalies of the intestinum tenue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Zfp36tm1.1Xen/Zfp36tm1.1Xen,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gpx1tm1Ysh/Gpx1tm1Ysh
Genetic Background: B6.129-Gpx1tm1Ysh

Allelic Composition: Zfp36tm1.1Xen/Zfp36tm1.1Xen,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N

 MP:0000693 spleen hyperplasia "increased cell number in the spleen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
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Allelic Composition: Gpx1tm1Ysh/Gpx1tm1Ysh
Genetic Background: B6.129-Gpx1tm1Ysh

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gpx1tm1Ysh/Gpx1tm1Ysh
Genetic Background: B6.129-Gpx1tm1Ysh

Allelic Composition: Zfp36tm1.1Xen/Zfp36tm1.1Xen,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N

 MP:0001194 dermatitis "inflammation of the skin" [J:65146]
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Allelic Composition: Gpx1tm1Ysh/Gpx1tm1Ysh
Genetic Background: B6.129-Gpx1tm1Ysh

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Gpx1tm1Ysh/Gpx1tm1Ysh
Genetic Background: B6.129-Gpx1tm1Ysh

Allelic Composition: Zfp36tm1.1Xen/Zfp36tm1.1Xen,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N

Allelic Composition: Zfp36tm1.2Xen/Zfp36tm1.2Xen
Genetic Background: C57BL/6-Zfp36tm1.2Xen

 MP:0001492 piloerection "the involuntary bristling of hairs" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Atp6v0a4tm1.1Fekf/Atp6v0a4+
Genetic Background: involves: C57BL/6

 MP:0001613 abnormal vasodilation "anomalous widening of the lumen of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tia1tm1Andp/Tia1tm1Andp
Genetic Background: B6.Cg-Tia1tm1Andp

Allelic Composition: Tnftm1Gkl/Tnftm1Gkl,Zfp36tm1Pjb/Zfp36tm1Pjb
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0001656 focal hepatic necrosis "a localized area of pathologic death of cells within, or a portion of, the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Zfp36tm1.1Xen/Zfp36tm1.1Xen,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gpx1tm1Ysh/Gpx1tm1Ysh
Genetic Background: B6.129-Gpx1tm1Ysh

Allelic Composition: Tia1tm1Andp/Tia1tm1Andp,Zfp36tm1Pjb/Zfp36tm1Pjb
Genetic Background: B6.Cg-Tia1tm1Andp Zfp36tm1Pjb

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
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Allelic Composition: Gpx1tm1Ysh/Gpx1tm1Ysh
Genetic Background: B6.129-Gpx1tm1Ysh

 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Zfp36tm1.1Xen/Zfp36tm1.1Xen,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N

 MP:0001852 conjunctivitis "inflammation of the mucous membrane that lines the inner surface of the eyelids" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60896]
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Allelic Composition: Gpx1tm1Ysh/Gpx1tm1Ysh
Genetic Background: B6.129-Gpx1tm1Ysh

 MP:0001853 heart inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the heart" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gpx1tm1Ysh/Gpx1tm1Ysh
Genetic Background: B6.129-Gpx1tm1Ysh

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Gpx1tm1Ysh/Gpx1tm1Ysh
Genetic Background: B6.129-Gpx1tm1Ysh

 MP:0001863 vascular inflammation "local accumulation of fluid, plasma proteins, and leukocytes in a blood vessel" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tia1tm1Andp/Tia1tm1Andp
Genetic Background: B6.Cg-Tia1tm1Andp

 MP:0001876 decreased inflammatory response "less than expected response to injury, infection, or insult" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tg(CMV-cre)1Cgn/0,Trp53tm4Att/Trp53+
Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gpx1tm1Ysh/Gpx1tm1Ysh
Genetic Background: B6.129-Gpx1tm1Ysh

Allelic Composition: Zfp36tm1.2Xen/Zfp36tm1.2Xen
Genetic Background: C57BL/6-Zfp36tm1.2Xen

 MP:0002371 abnormal thymus cortex morphology "anomalous structure or development of the outer area of thymus lobules" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gpx1tm1Ysh/Gpx1tm1Ysh
Genetic Background: B6.129-Gpx1tm1Ysh

 MP:0002375 abnormal thymus medulla morphology "anomalous structure or development of the inner area of thymus lobules" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gpx1tm1Ysh/Gpx1tm1Ysh
Genetic Background: B6.129-Gpx1tm1Ysh

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tia1tm1Andp/Tia1tm1Andp,Zfp36tm1Pjb/Zfp36tm1Pjb
Genetic Background: B6.Cg-Tia1tm1Andp Zfp36tm1Pjb

Allelic Composition: Zfp36tm1Pjb/Zfp36tm1Pjb
Genetic Background: B6.Cg-Zfp36tm1Pjb

 MP:0002843 decreased blood pressure "decreased tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Zfp36tm1Pjb/Zfp36tm1Pjb
Genetic Background: B6.Cg-Zfp36tm1Pjb

 MP:0002941 increased circulating alanine transaminase level "increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Zfp36tm1.1Xen/Zfp36tm1.1Xen,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N

 MP:0002944 increased lactate dehydrogenase level "greater than the normal concentration of this enzyme, which catalyzes the interconversion of lactate and pyruvate" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:87714]
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Allelic Composition: Zfp36tm1.1Xen/Zfp36tm1.1Xen,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N

 MP:0002993 arthritis "joint inflammation, marked by changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gpx1tm1Ysh/Gpx1tm1Ysh
Genetic Background: B6.129-Gpx1tm1Ysh

Allelic Composition: Tia1tm1Andp/Tia1tm1Andp,Zfp36tm1Pjb/Zfp36tm1Pjb
Genetic Background: B6.Cg-Tia1tm1Andp Zfp36tm1Pjb

Allelic Composition: Zfp36tm1Pjb/Zfp36tm1Pjb
Genetic Background: B6.Cg-Zfp36tm1Pjb

Allelic Composition: Zfp36tm1.1Xen/Zfp36tm1.1Xen,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N

 MP:0003436 resistance to induced arthritis "less likely to be striken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:75303]
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Allelic Composition: Tg(CMV-cre)1Cgn/0,Trp53tm4Att/Trp53+
Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6J

 MP:0003674 oxidative stress "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Zfp36tm1Pjb/Zfp36tm1Pjb
Genetic Background: B6.Cg-Zfp36tm1Pjb

Allelic Composition: Tnftm1Gkl/Tnftm1Gkl,Zfp36tm1Pjb/Zfp36tm1Pjb
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0003957 abnormal nitric oxide homeostasis "anomaly in the state of equilibrium in the body of nitric oxide, a free radical gas and a potent vasodilator" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Zfp36tm1Pjb/Zfp36tm1Pjb
Genetic Background: B6.Cg-Zfp36tm1Pjb

 MP:0004800 decreased susceptibility to experimental autoimmune encephalomyelitis "reduced likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tg(CMV-cre)1Cgn/0,Trp53tm4Att/Trp53+
Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6J

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Zfp36tm1.1Xen/Zfp36tm1.1Xen,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Zfp36tm1Pjb/Zfp36tm1Pjb
Genetic Background: B6.Cg-Zfp36tm1Pjb

 MP:0005202 lethargy "mild impairment of consciousness resulting in reduced alertness and awareness; ultimately due to generalized brain dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Zfp36tm1.1Xen/Zfp36tm1.1Xen,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N

 MP:0005325 abnormal glomerulus "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gpx1tm1Ysh/Gpx1tm1Ysh
Genetic Background: B6.129-Gpx1tm1Ysh

Allelic Composition: Zfp36tm1.1Xen/Zfp36tm1.1Xen,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N

 MP:0005329 abnormal cardiac muscle morphology "anomalous structure of the involuntary muscle comprising the myocardium " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Zfp36tm1.1Xen/Zfp36tm1.1Xen,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N

 MP:0005426 tachypnea "rapid breathing" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Zfp36tm1.1Xen/Zfp36tm1.1Xen,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N

 MP:0005505 increased platelet count "greater than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Zfp36tm1Pjb/Zfp36tm1Pjb
Genetic Background: B6.Cg-Zfp36tm1Pjb

 MP:0005534 decreased body temperature "less than the level of heat natural to a living being" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Zfp36tm1.1Xen/Zfp36tm1.1Xen,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Zfp36tm1.1Xen/Zfp36tm1.1Xen,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N

 MP:0008412 increased cellular sensitivity to oxidative stress "greater incidence of cell death or enhanced production of reactive oxygen species after exposure to a variety of stress conditions including ionizing radiation, exposure to xenobiotics, inflammation, and phagocytosis" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Zfp36tm1Pjb/Zfp36tm1Pjb
Genetic Background: B6.Cg-Zfp36tm1Pjb

 MP:0008553 increased circulating tumor necrosis factor level "greater amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Zfp36tm1.1Xen/Zfp36tm1.1Xen,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N

 MP:0008735 increased susceptibility to endotoxin shock "more than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Zfp36tm1.1Xen/Zfp36tm1.1Xen,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N

 MP:0008843 absent subcutaneous adipose tissue "absence of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gpx1tm1Ysh/Gpx1tm1Ysh
Genetic Background: B6.129-Gpx1tm1Ysh

 MP:0010373 myeloid hyperplasia "greater than normal number of nucleated cells of the myeloid lineage (a monocyte, granulocyte, or mast cell), found in blood or other tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tnftm3Gkl/Tnftm3Gkl
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0010922 alveolitis "inflammation of the small sac-like dilations of the distal airspace of the lung; acute pulmonary alveolitis involves exudate into the pulmonary alveoli and impaired gas exchange" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Zfp36tm1.1Xen/Zfp36tm1.1Xen,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Nsd3tm1b(EUCOMM)Hmgu/Nsd3tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Nsd3tm1b(EUCOMM)Hmgu/H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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