ENSGALG00000002283


Gallus gallus

Features
Gene ID: ENSGALG00000002283
  
Biological name :MAPKAPK3
  
Synonyms : Gallus gallus mitogen-activated protein kinase-activated protein kinase 3 (MAPKAPK3), mRNA. / MAPKAPK3
  
Possible biological names infered from orthology : MAP kinase-activated protein kinase 3 / mitogen-activated protein kinase-activated protein kinase 3 / Q16644 / Q3UMW7
  
Species: Gallus gallus
  
Chr. number: 12
Strand: 1
Band:
Gene start: 1880037
Gene end: 1922149
  
Corresponding Affymetrix probe sets: GgaAffx.1528.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000003578
NCBI entrez gene - 415917     See in Manteia.
RefSeq - NM_001321558
RefSeq - XM_015292774
RefSeq Peptide - NP_001308487
swissprot - E1BT35
Ensembl - ENSGALG00000002283
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mapkapk3ENSDARG00000111612Danio rerio
 Q16644ENSG00000114738Homo sapiens
 Q3UMW7ENSMUSG00000032577Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MAPKAPK2 / mitogen-activated protein kinase-activated protein kinase 2 / P49137* / P49138* / MAP kinase-activated protein kinase 2 *ENSGALG0000000088369
MAPKAPK5 / mitogen-activated protein kinase-activated protein kinase 5 / Q8IW41* / O54992* / Gm42878* / MAP kinase-activated protein kinase 5 *ENSGALG0000000474340
MKNK2 / MAP kinase interacting serine/threonine kinase 2 / Q8CDB0* / Q9HBH9* / MAP kinase-interacting serine/threonine-protein kinase 2 *ENSGALG0000000384531
MKNK1 / MAP kinase interacting serine/threonine kinase 1 / Q9BUB5*ENSGALG0000001044030


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR027442  MAP kinase activated protein kinase, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IBA
 biological_processGO:0002224 toll-like receptor signaling pathway IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IBA
 biological_processGO:0018105 peptidyl-serine phosphorylation IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0034097 response to cytokine IEA
 biological_processGO:0044351 macropinocytosis IEA
 biological_processGO:0046777 protein autophosphorylation IBA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004683 calmodulin-dependent protein kinase activity IBA
 molecular_functionGO:0004871 obsolete signal transducer activity IBA
 molecular_functionGO:0005516 calmodulin binding IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0009931 calcium-dependent protein serine/threonine kinase activity IBA
 molecular_functionGO:0051019 mitogen-activated protein kinase binding IBA


Pathways (from Reactome)
Pathway description
p38MAPK events
Oxidative Stress Induced Senescence
VEGFA-VEGFR2 Pathway
activated TAK1 mediates p38 MAPK activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000042491 P62801 / Histone H4   / reaction
 ENSGALG00000040023 MAPK11 / mitogen-activated protein kinase 11 / Q15759* / Q9WUI1*  / complex / reaction
 ENSGALG00000020078 H3F3C / histone H3.2 / H3.Y* / H3F3B* / H3F3A* / Q6NXT2* / P84243* / P84244* / Histone H3.3 * / H3 histone family member 3B* / H3 histone family member 3A* / H3 histone family member 3C* /...  / reaction
 ENSGALG00000042833 MAPK14 / mitogen-activated protein kinase 14 / P47811* / Q16539*  / complex / reaction
 ENSGALG00000043062 P84229 / HIST2H3D / Histone H3.2 / Q71DI3* / histone cluster 2 H3 family member d*  / reaction
 ENSGALG00000004370 MAP2K6 / mitogen-activated protein kinase kinase 6 / P52564* / P70236*  / reaction
 ENSGALG00000041285 MAP2K3 / mitogen-activated protein kinase kinase 3 / O09110* / P46734*  / reaction






 

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