ENSG00000116711


Homo sapiens

Features
Gene ID: ENSG00000116711
  
Biological name :PLA2G4A
  
Synonyms : P47712 / phospholipase A2 group IVA / PLA2G4A
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: q31.1
Gene start: 186828953
Gene end: 186988981
  
Corresponding Affymetrix probe sets: 210145_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000356436
NCBI entrez gene - 5321     See in Manteia.
OMIM - 600522
RefSeq - XM_011509642
RefSeq - NM_001311193
RefSeq - NM_024420
RefSeq - XM_005245267
RefSeq Peptide - NP_001298122
RefSeq Peptide - NP_077734
swissprot - P47712
Ensembl - ENSG00000116711
  
Related genetic diseases (OMIM): 600522 - Phospholipase A2, group IV A, deficiency of
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pla2g4aaENSDARG00000024546Danio rerio
 pla2g4abENSDARG00000017141Danio rerio
 P49147ENSGALG00000005065Gallus gallus
 P47713ENSMUSG00000056220Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q3MJ16 / PLA2G4E / phospholipase A2 group IVEENSG0000018808930
Q68DD2 / PLA2G4F / phospholipase A2 group IVFENSG0000016890730
Q86XP0 / PLA2G4D / phospholipase A2 group IVDENSG0000015933728
P0C869 / PLA2G4B / phospholipase A2 group IVBENSG0000024370826
JMJD7-PLA2G4B / JMJD7-PLA2G4B readthroughENSG0000016897026
Q9UP65 / PLA2G4C / phospholipase A2 group IVCENSG0000010549917


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR002642  Lysophospholipase, catalytic domain
 IPR016035  Acyl transferase/acyl hydrolase/lysophospholipase
 IPR035892  C2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006644 phospholipid metabolic process TAS
 biological_processGO:0006654 phosphatidic acid biosynthetic process TAS
 biological_processGO:0006663 platelet activating factor biosynthetic process NAS
 biological_processGO:0006690 icosanoid metabolic process NAS
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0009395 phospholipid catabolic process IEA
 biological_processGO:0016042 lipid catabolic process IEA
 biological_processGO:0019369 arachidonic acid metabolic process TAS
 biological_processGO:0035965 cardiolipin acyl-chain remodeling TAS
 biological_processGO:0036148 phosphatidylglycerol acyl-chain remodeling TAS
 biological_processGO:0036149 phosphatidylinositol acyl-chain remodeling TAS
 biological_processGO:0036150 phosphatidylserine acyl-chain remodeling TAS
 biological_processGO:0036151 phosphatidylcholine acyl-chain remodeling TAS
 biological_processGO:0036152 phosphatidylethanolamine acyl-chain remodeling TAS
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0046456 icosanoid biosynthetic process IEA
 biological_processGO:0050482 arachidonic acid secretion IEA
 biological_processGO:0071236 cellular response to antibiotic IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005743 mitochondrial inner membrane TAS
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005811 lipid droplet IDA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 molecular_functionGO:0004620 phospholipase activity IEA
 molecular_functionGO:0004622 lysophospholipase activity TAS
 molecular_functionGO:0004623 phospholipase A2 activity TAS
 molecular_functionGO:0005509 calcium ion binding IDA
 molecular_functionGO:0005544 calcium-dependent phospholipid binding IDA
 molecular_functionGO:0008970 phosphatidylcholine 1-acylhydrolase activity TAS
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0047498 calcium-dependent phospholipase A2 activity EXP
 molecular_functionGO:0102567 phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine) IEA
 molecular_functionGO:0102568 phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine) IEA


Pathways (from Reactome)
Pathway description
phospho-PLA2 pathway
Acyl chain remodelling of PC
Acyl chain remodeling of CL
Acyl chain remodelling of PS
Acyl chain remodelling of PE
Acyl chain remodelling of PI
Acyl chain remodelling of PG
Hydrolysis of LPC
Synthesis of PA
Arachidonic acid metabolism
ADP signalling through P2Y purinoceptor 1
Platelet sensitization by LDL
COPI-independent Golgi-to-ER retrograde traffic


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000100030 MAPK1 / P28482 / mitogen-activated protein kinase 1  / reaction
 ENSG00000112062 MAPK14 / Q16539 / mitogen-activated protein kinase 14  / reaction






 

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