ENSG00000105499


Homo sapiens

Features
Gene ID: ENSG00000105499
  
Biological name :PLA2G4C
  
Synonyms : phospholipase A2 group IVC / PLA2G4C / Q9UP65
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: -1
Band: q13.33
Gene start: 48047843
Gene end: 48110817
  
Corresponding Affymetrix probe sets: 1554810_at (Human Genome U133 Plus 2.0 Array)   209785_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000472977
Ensembl peptide - ENSP00000472546
Ensembl peptide - ENSP00000473250
Ensembl peptide - ENSP00000346228
Ensembl peptide - ENSP00000468972
Ensembl peptide - ENSP00000469473
Ensembl peptide - ENSP00000469528
Ensembl peptide - ENSP00000470418
Ensembl peptide - ENSP00000471196
Ensembl peptide - ENSP00000471328
Ensembl peptide - ENSP00000471759
NCBI entrez gene - 8605     See in Manteia.
OMIM - 603602
RefSeq - XM_017027413
RefSeq - NM_001159322
RefSeq - NM_001159323
RefSeq - NM_003706
RefSeq - XM_011527431
RefSeq - XM_011527432
RefSeq - XM_011527433
RefSeq - XM_017027411
RefSeq - XM_017027412
RefSeq Peptide - NP_001152795
RefSeq Peptide - NP_001152794
RefSeq Peptide - NP_003697
swissprot - M0QX83
swissprot - M0QY18
swissprot - M0QZB1
swissprot - M0R0F6
swissprot - M0R0M8
swissprot - M0R1B4
swissprot - M0R339
swissprot - M0R3I9
swissprot - Q9UP65
swissprot - A0A024QZH0
Ensembl - ENSG00000105499
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 LO018584.1ENSDARG00000101721Danio rerio
 si:ch73-55i23.1ENSDARG00000045982Danio rerio
 si:ch73-55i23.1ENSDARG00000042090Danio rerio
 zgc:101699ENSDARG00000033355Danio rerio
 Q64GA5ENSMUSG00000033847Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q68DD2 / PLA2G4F / phospholipase A2 group IVFENSG0000016890727
P0C869 / PLA2G4B / phospholipase A2 group IVBENSG0000024370825
JMJD7-PLA2G4B / JMJD7-PLA2G4B readthroughENSG0000016897025
Q86XP0 / PLA2G4D / phospholipase A2 group IVDENSG0000015933725
Q3MJ16 / PLA2G4E / phospholipase A2 group IVEENSG0000018808925
P47712 / PLA2G4A / phospholipase A2 group IVAENSG0000011671123


Protein motifs (from Interpro)
Interpro ID Name
 IPR002642  Lysophospholipase, catalytic domain
 IPR016035  Acyl transferase/acyl hydrolase/lysophospholipase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006644 phospholipid metabolic process TAS
 biological_processGO:0006954 inflammatory response NAS
 biological_processGO:0007567 parturition NAS
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0009395 phospholipid catabolic process IEA
 biological_processGO:0016042 lipid catabolic process IEA
 biological_processGO:0019369 arachidonic acid metabolic process NAS
 biological_processGO:0035556 intracellular signal transduction NAS
 biological_processGO:0036149 phosphatidylinositol acyl-chain remodeling TAS
 biological_processGO:0036151 phosphatidylcholine acyl-chain remodeling TAS
 biological_processGO:0036152 phosphatidylethanolamine acyl-chain remodeling TAS
 biological_processGO:0046475 glycerophospholipid catabolic process IDA
 cellular_componentGO:0005635 nuclear envelope IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005938 cell cortex IEA
 cellular_componentGO:0016020 membrane TAS
 molecular_functionGO:0004620 phospholipase activity IEA
 molecular_functionGO:0004622 lysophospholipase activity TAS
 molecular_functionGO:0004623 phospholipase A2 activity TAS
 molecular_functionGO:0005543 phospholipid binding NAS
 molecular_functionGO:0008970 phosphatidylcholine 1-acylhydrolase activity TAS
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0047499 calcium-independent phospholipase A2 activity IDA
 molecular_functionGO:0102567 phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine) IEA
 molecular_functionGO:0102568 phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine) IEA


Pathways (from Reactome)
Pathway description
Acyl chain remodelling of PC
Acyl chain remodelling of PE
Acyl chain remodelling of PI
Hydrolysis of LPC
Hydrolysis of LPE


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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